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A Comprehensive Review on l-Asparaginase and Its Applications

l-asparaginase (LA) catalyzes the degradation of asparagine, an essential amino acid for leukemic cells, into ammonia and aspartate. Owing to its ability to inhibit protein biosynthesis in lymphoblasts, LA is used to treat acute lymphoblastic leukemia (ALL). Different isozymes of this enzyme have be...

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Main Authors: Batool, Tahira, Makky, Essam A., Ali, Muna Jalal, M. M., Yusoff
Format: Article
Language:English
Published: Springer 2016
Subjects:
Q Science (General)
Online Access:http://umpir.ump.edu.my/id/eprint/12747/1/A%20Comprehensive%20Review%20on%20l-Asparaginase%20and%20Its%20Applications.pdf
http://umpir.ump.edu.my/id/eprint/12747/
http://dx.doi.org/10.1007/s12010-015-1917-3
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spelling my.ump.umpir.127472018-07-26T06:50:56Z http://umpir.ump.edu.my/id/eprint/12747/ A Comprehensive Review on l-Asparaginase and Its Applications Batool, Tahira Makky, Essam A. Ali, Muna Jalal M. M., Yusoff Q Science (General) l-asparaginase (LA) catalyzes the degradation of asparagine, an essential amino acid for leukemic cells, into ammonia and aspartate. Owing to its ability to inhibit protein biosynthesis in lymphoblasts, LA is used to treat acute lymphoblastic leukemia (ALL). Different isozymes of this enzyme have been isolated from a wide range of organisms, including plants and terrestrial and marine microorganisms. Pieces of information about the three-dimensional structure of l-asparaginase from Escherichia coli and Erwinia sp. have identified residues that are essential for catalytic activity. This review catalogues the major sources of l-asparaginase, the methods of its production through the solid state (SSF) and submerged (SmF) fermentation, purification, and characterization as well as its biological roles. In the same breath, this article explores both the past and present applications of this important enzyme and discusses its future prospects. Springer 2016 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/12747/1/A%20Comprehensive%20Review%20on%20l-Asparaginase%20and%20Its%20Applications.pdf Batool, Tahira and Makky, Essam A. and Ali, Muna Jalal and M. M., Yusoff (2016) A Comprehensive Review on l-Asparaginase and Its Applications. Applied Biochemistry and Biotechnology, 178 (5). pp. 900-923. ISSN 1559-0291 http://dx.doi.org/10.1007/s12010-015-1917-3 DOI: 10.1007/s12010-015-1917-3
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic Q Science (General)
spellingShingle Q Science (General)
Batool, Tahira
Makky, Essam A.
Ali, Muna Jalal
M. M., Yusoff
A Comprehensive Review on l-Asparaginase and Its Applications
description l-asparaginase (LA) catalyzes the degradation of asparagine, an essential amino acid for leukemic cells, into ammonia and aspartate. Owing to its ability to inhibit protein biosynthesis in lymphoblasts, LA is used to treat acute lymphoblastic leukemia (ALL). Different isozymes of this enzyme have been isolated from a wide range of organisms, including plants and terrestrial and marine microorganisms. Pieces of information about the three-dimensional structure of l-asparaginase from Escherichia coli and Erwinia sp. have identified residues that are essential for catalytic activity. This review catalogues the major sources of l-asparaginase, the methods of its production through the solid state (SSF) and submerged (SmF) fermentation, purification, and characterization as well as its biological roles. In the same breath, this article explores both the past and present applications of this important enzyme and discusses its future prospects.
format Article
author Batool, Tahira
Makky, Essam A.
Ali, Muna Jalal
M. M., Yusoff
author_facet Batool, Tahira
Makky, Essam A.
Ali, Muna Jalal
M. M., Yusoff
author_sort Batool, Tahira
title A Comprehensive Review on l-Asparaginase and Its Applications
title_short A Comprehensive Review on l-Asparaginase and Its Applications
title_full A Comprehensive Review on l-Asparaginase and Its Applications
title_fullStr A Comprehensive Review on l-Asparaginase and Its Applications
title_full_unstemmed A Comprehensive Review on l-Asparaginase and Its Applications
title_sort comprehensive review on l-asparaginase and its applications
publisher Springer
publishDate 2016
url http://umpir.ump.edu.my/id/eprint/12747/1/A%20Comprehensive%20Review%20on%20l-Asparaginase%20and%20Its%20Applications.pdf
http://umpir.ump.edu.my/id/eprint/12747/
http://dx.doi.org/10.1007/s12010-015-1917-3
_version_ 1643666982595198976
score 13.211869

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