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Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia

To date, information on the variations in IL-28 genotypes among different ethnic groups in Malaysia is still limited.After 24 weeks of treatment completion, blood samples were collected from all the patients to determine the SVR, and to identify their IL-28 genotypes using the methods and instrument...

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Main Authors: Hoe, C.-H., Suan, M.A.M., Tang, T.-H., Kiew, K.-K., Hassan, M.R.A., Chan, H.-K.
Format: Conference or Workshop Item
Language:English
Published: 2018
Online Access:http://discol.umk.edu.my/id/eprint/8826/1/interleukin-28-polymorphism.pdf
http://discol.umk.edu.my/id/eprint/8826/
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spelling my.umk.eprints.88262022-05-23T11:08:38Z http://discol.umk.edu.my/id/eprint/8826/ Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia Hoe, C.-H. Suan, M.A.M. Tang, T.-H. Kiew, K.-K. Hassan, M.R.A. Chan, H.-K. To date, information on the variations in IL-28 genotypes among different ethnic groups in Malaysia is still limited.After 24 weeks of treatment completion, blood samples were collected from all the patients to determine the SVR, and to identify their IL-28 genotypes using the methods and instruments as described in a similar study. The associations between IL28 genotypes and both ethnicity and SVR were confirmed using the Pearson's chi-square tests.In total, 72 patients were identified to have the CC genotype at the IL-28 polymorphic site. Interestingly, a higher proportion of the Chinese and Malay patients were found to have the CC genotype, as compared with the Indian patients, 62.5% of whom had the non-CC genotypes. The SVR rates for genotype-1 and genotype-3 HCV infections found in this study were, respectively, 53.3% and 68.2%. Additionally, despite the HCV genotypes, the patients with the CC genotype were confirmed to have a higher SVR rate compared with those with the nonCC genotypes. The information on variations in IL-28 genotypes across different ethnic groups could also be helpful in predicting responses to the interferon-based treatment among the CHC patients in Malaysia. 2018-04 Conference or Workshop Item NonPeerReviewed text en http://discol.umk.edu.my/id/eprint/8826/1/interleukin-28-polymorphism.pdf Hoe, C.-H. and Suan, M.A.M. and Tang, T.-H. and Kiew, K.-K. and Hassan, M.R.A. and Chan, H.-K. (2018) Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia. In: Medical Journal of Malaysia.
institution Universiti Malaysia Kelantan
building Perpustakaan Universiti Malaysia Kelantan
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Kelantan
content_source UMK Institutional Repository
url_provider http://umkeprints.umk.edu.my/
language English
description To date, information on the variations in IL-28 genotypes among different ethnic groups in Malaysia is still limited.After 24 weeks of treatment completion, blood samples were collected from all the patients to determine the SVR, and to identify their IL-28 genotypes using the methods and instruments as described in a similar study. The associations between IL28 genotypes and both ethnicity and SVR were confirmed using the Pearson's chi-square tests.In total, 72 patients were identified to have the CC genotype at the IL-28 polymorphic site. Interestingly, a higher proportion of the Chinese and Malay patients were found to have the CC genotype, as compared with the Indian patients, 62.5% of whom had the non-CC genotypes. The SVR rates for genotype-1 and genotype-3 HCV infections found in this study were, respectively, 53.3% and 68.2%. Additionally, despite the HCV genotypes, the patients with the CC genotype were confirmed to have a higher SVR rate compared with those with the nonCC genotypes. The information on variations in IL-28 genotypes across different ethnic groups could also be helpful in predicting responses to the interferon-based treatment among the CHC patients in Malaysia.
format Conference or Workshop Item
author Hoe, C.-H.
Suan, M.A.M.
Tang, T.-H.
Kiew, K.-K.
Hassan, M.R.A.
Chan, H.-K.
spellingShingle Hoe, C.-H.
Suan, M.A.M.
Tang, T.-H.
Kiew, K.-K.
Hassan, M.R.A.
Chan, H.-K.
Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia
author_facet Hoe, C.-H.
Suan, M.A.M.
Tang, T.-H.
Kiew, K.-K.
Hassan, M.R.A.
Chan, H.-K.
author_sort Hoe, C.-H.
title Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia
title_short Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia
title_full Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia
title_fullStr Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia
title_full_unstemmed Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia
title_sort interleukin-28 polymorphism: ethnic variations and the response to chronic hepatitis c treatment in malaysia
publishDate 2018
url http://discol.umk.edu.my/id/eprint/8826/1/interleukin-28-polymorphism.pdf
http://discol.umk.edu.my/id/eprint/8826/
_version_ 1763304018656886784
score 13.211869

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