An economic evaluation of Levofloxacin versus Cefuroxime Axetil in the outpatient treatment of adults with community-acquired pneumonia
Objective: To examine treatment costs of community-acquired pneumonia (CAP) in adult outpatients given oral (po) levofloxacin or cefuroxime axetil as initial therapy. Study Design: Patients with a primary diagnosis of CAP were enrolled in a multicenter, prospective, randomized, open-label, active-c...
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2000
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| Online Access: | http://discol.umk.edu.my/id/eprint/8390/ https://www.researchgate.net/publication/12345688_An_economic_evaluation_of_levofloxacin_versus_cefuroxime_axetil_in_the_outpatient_treatment_of_adults_with_community-acquired_pneumonia |
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my.umk.eprints.83902022-05-23T10:27:15Z http://discol.umk.edu.my/id/eprint/8390/ An economic evaluation of Levofloxacin versus Cefuroxime Axetil in the outpatient treatment of adults with community-acquired pneumonia Rittenhouse, Brian E. Stinnett, Aaron.A. Dulisse, Brian Henke, Curtis.J. Potter, Lori Balakrishnan Parasuraman Martens, Leon L. Williams, R. Rex Kojak, Claire Objective: To examine treatment costs of community-acquired pneumonia (CAP) in adult outpatients given oral (po) levofloxacin or cefuroxime axetil as initial therapy. Study Design: Patients with a primary diagnosis of CAP were enrolled in a multicenter, prospective, randomized, open-label, active-controlled Phase III clinical trial. Both inpatients and outpatients were assigned to 1 of 2 treatment groups: (1) intravenous (IV) or po levofloxacin; or (2) IV ceftriaxone and/or po cefuroxime axetil. Methods: To make legitimate and meaningful cost comparisons between similar types of patients receiving drugs via the same route of administration (ie, orally), this outpatient economic study examined the resource utilization of the 211 patients enrolled as outpatients who received oral formulations as initial treatment (levofloxacin, 103 patients; cefuroxime axetil, 108 patients). Resource utilization data and clinical trial data were collected concurrently. To generate cost estimates, Medicare cost estimates for resources were multiplied by the resource units used by patients in each treatment arm. Results: Cost estimates indicated a total cost difference that favored the levofloxacin group (base case: $169; sensitivity analysis: $223 [P = .008]). The results for the base case were not significant (P = .094). In addition, within the cost categories, there was a statistically significant study drug cost differential favoring levofloxacin ($86; P = .0001 for both the base case and sensitivity analysis). Conclusion: Oral levofloxacin is less costly than oral cefuroxime axetil in the outpatient treatment of adults with CAP. (Am J Manag Care 2000;6:381-389) 2000-04 Non-Indexed Article NonPeerReviewed Rittenhouse, Brian E. and Stinnett, Aaron.A. and Dulisse, Brian and Henke, Curtis.J. and Potter, Lori and Balakrishnan Parasuraman and Martens, Leon L. and Williams, R. Rex and Kojak, Claire (2000) An economic evaluation of Levofloxacin versus Cefuroxime Axetil in the outpatient treatment of adults with community-acquired pneumonia. The American Journal Of Managed Care, 6 (3). pp. 381-389. https://www.researchgate.net/publication/12345688_An_economic_evaluation_of_levofloxacin_versus_cefuroxime_axetil_in_the_outpatient_treatment_of_adults_with_community-acquired_pneumonia |
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| description |
Objective: To examine treatment costs of community-acquired
pneumonia (CAP) in adult outpatients
given oral (po) levofloxacin or cefuroxime axetil as
initial therapy.
Study Design: Patients with a primary diagnosis of
CAP were enrolled in a multicenter, prospective,
randomized, open-label, active-controlled Phase III
clinical trial. Both inpatients and outpatients were
assigned to 1 of 2 treatment groups: (1) intravenous
(IV) or po levofloxacin; or (2) IV ceftriaxone and/or
po cefuroxime axetil.
Methods: To make legitimate and meaningful cost
comparisons between similar types of patients
receiving drugs via the same route of administration
(ie, orally), this outpatient economic study examined
the resource utilization of the 211 patients enrolled
as outpatients who received oral formulations as initial
treatment (levofloxacin, 103 patients; cefuroxime
axetil, 108 patients). Resource utilization data
and clinical trial data were collected concurrently.
To generate cost estimates, Medicare cost estimates
for resources were multiplied by the resource units
used by patients in each treatment arm.
Results: Cost estimates indicated a total cost difference
that favored the levofloxacin group (base
case: $169; sensitivity analysis: $223 [P = .008]).
The results for the base case were not significant
(P = .094). In addition, within the cost categories,
there was a statistically significant study drug cost
differential favoring levofloxacin ($86; P = .0001 for
both the base case and sensitivity analysis).
Conclusion: Oral levofloxacin is less costly than
oral cefuroxime axetil in the outpatient treatment of
adults with CAP.
(Am J Manag Care 2000;6:381-389) |
| format |
Non-Indexed Article |
| author |
Rittenhouse, Brian E. Stinnett, Aaron.A. Dulisse, Brian Henke, Curtis.J. Potter, Lori Balakrishnan Parasuraman Martens, Leon L. Williams, R. Rex Kojak, Claire |
| spellingShingle |
Rittenhouse, Brian E. Stinnett, Aaron.A. Dulisse, Brian Henke, Curtis.J. Potter, Lori Balakrishnan Parasuraman Martens, Leon L. Williams, R. Rex Kojak, Claire An economic evaluation of Levofloxacin versus Cefuroxime Axetil in the outpatient treatment of adults with community-acquired pneumonia |
| author_facet |
Rittenhouse, Brian E. Stinnett, Aaron.A. Dulisse, Brian Henke, Curtis.J. Potter, Lori Balakrishnan Parasuraman Martens, Leon L. Williams, R. Rex Kojak, Claire |
| author_sort |
Rittenhouse, Brian E. |
| title |
An economic evaluation of Levofloxacin versus
Cefuroxime Axetil in the outpatient treatment of adults
with community-acquired pneumonia |
| title_short |
An economic evaluation of Levofloxacin versus
Cefuroxime Axetil in the outpatient treatment of adults
with community-acquired pneumonia |
| title_full |
An economic evaluation of Levofloxacin versus
Cefuroxime Axetil in the outpatient treatment of adults
with community-acquired pneumonia |
| title_fullStr |
An economic evaluation of Levofloxacin versus
Cefuroxime Axetil in the outpatient treatment of adults
with community-acquired pneumonia |
| title_full_unstemmed |
An economic evaluation of Levofloxacin versus
Cefuroxime Axetil in the outpatient treatment of adults
with community-acquired pneumonia |
| title_sort |
economic evaluation of levofloxacin versus
cefuroxime axetil in the outpatient treatment of adults
with community-acquired pneumonia |
| publishDate |
2000 |
| url |
http://discol.umk.edu.my/id/eprint/8390/ https://www.researchgate.net/publication/12345688_An_economic_evaluation_of_levofloxacin_versus_cefuroxime_axetil_in_the_outpatient_treatment_of_adults_with_community-acquired_pneumonia |
| _version_ |
1763303977401712640 |
| score |
13.223943 |