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Toxicity evaluation of standardized and nanoliposomal extracts of Labisia pumila whole plant (Blume, Myrsinaceae) in Sprague Dawley rats

Purpose: To investigate the toxicity of Labisia pumila standardized extract (LPE) and its liposomal extract (LLP). Methods: For acute toxicity study, LPE or LLP was orally administered (2000 mg/kg) in single doses to Sprague Dawley rats and the routine activity of the rats was continuously monitored...

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Main Authors: Ahmed Saeed, Mohammed Ali, Memon, Abdul Hakeem, Hamil, Mohd Shahrul Ridzuan, Hooi, Kheng Beh, Mohammed Saghir, Sultan Ayesh, Kaur, Gurjeet, Sadikun, Amirin, Ismail, Zhari
Format: Indexed Article
Language:English
Published: 2018
Online Access:http://discol.umk.edu.my/id/eprint/7330/1/Toxicity%20evaluation%20of%20standardized%20and%20nanoliposomal%20extracts%20of%20Labisia%20pumila%20whole%20plant%20%28Blume%2C%20Myrsinaceae%29%20in%20Sprague%20Dawley%20rats.pdf
http://discol.umk.edu.my/id/eprint/7330/
https://www.ajol.info/index.php/tjpr/article/view/178173
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spelling my.umk.eprints.73302022-05-23T15:49:14Z http://discol.umk.edu.my/id/eprint/7330/ Toxicity evaluation of standardized and nanoliposomal extracts of Labisia pumila whole plant (Blume, Myrsinaceae) in Sprague Dawley rats Ahmed Saeed, Mohammed Ali Memon, Abdul Hakeem Hamil, Mohd Shahrul Ridzuan Hooi, Kheng Beh Mohammed Saghir, Sultan Ayesh Kaur, Gurjeet Sadikun, Amirin Ismail, Zhari Purpose: To investigate the toxicity of Labisia pumila standardized extract (LPE) and its liposomal extract (LLP). Methods: For acute toxicity study, LPE or LLP was orally administered (2000 mg/kg) in single doses to Sprague Dawley rats and the routine activity of the rats was continuously monitored for a total of 14 days. After 14 days of treatment, all rats were sacrificed and their vital organs were excised, weighed and macroscopically examined, while for a repeated dose toxicity study, the rats were orally administered with LPE or LLP at the selected doses (250, 500 and 1000 mg/kg) for a period of 28 days. The animals were sacrificed (anaesthetized by sodium pentobarbitone and blood was collected by cardiac puncture), followed by examination of their body organs and blood serum. Results: LPE and LLP at 2000 mg/kg did not produce mortality or significant changes in the general behaviour, body weight and organ gross appearance of the rats. In repeated dose toxicity study no significant changes in, growth, organ weights, haematological parameters, biochemical values and histological features of vital organs of the treated groups, compared to the control group. Conclusion: The no-adverse-effect-level for LPE and LLP is (1000 mg/kg/day) when administered orally for 28 days. 2018 Indexed Article NonPeerReviewed text en http://discol.umk.edu.my/id/eprint/7330/1/Toxicity%20evaluation%20of%20standardized%20and%20nanoliposomal%20extracts%20of%20Labisia%20pumila%20whole%20plant%20%28Blume%2C%20Myrsinaceae%29%20in%20Sprague%20Dawley%20rats.pdf Ahmed Saeed, Mohammed Ali and Memon, Abdul Hakeem and Hamil, Mohd Shahrul Ridzuan and Hooi, Kheng Beh and Mohammed Saghir, Sultan Ayesh and Kaur, Gurjeet and Sadikun, Amirin and Ismail, Zhari (2018) Toxicity evaluation of standardized and nanoliposomal extracts of Labisia pumila whole plant (Blume, Myrsinaceae) in Sprague Dawley rats. Tropical Journal of Pharmaceutical Research, 17 (8). pp. 1557-1564. ISSN 1596-5996 https://www.ajol.info/index.php/tjpr/article/view/178173
institution Universiti Malaysia Kelantan
building Perpustakaan Universiti Malaysia Kelantan
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Kelantan
content_source UMK Institutional Repository
url_provider http://umkeprints.umk.edu.my/
language English
description Purpose: To investigate the toxicity of Labisia pumila standardized extract (LPE) and its liposomal extract (LLP). Methods: For acute toxicity study, LPE or LLP was orally administered (2000 mg/kg) in single doses to Sprague Dawley rats and the routine activity of the rats was continuously monitored for a total of 14 days. After 14 days of treatment, all rats were sacrificed and their vital organs were excised, weighed and macroscopically examined, while for a repeated dose toxicity study, the rats were orally administered with LPE or LLP at the selected doses (250, 500 and 1000 mg/kg) for a period of 28 days. The animals were sacrificed (anaesthetized by sodium pentobarbitone and blood was collected by cardiac puncture), followed by examination of their body organs and blood serum. Results: LPE and LLP at 2000 mg/kg did not produce mortality or significant changes in the general behaviour, body weight and organ gross appearance of the rats. In repeated dose toxicity study no significant changes in, growth, organ weights, haematological parameters, biochemical values and histological features of vital organs of the treated groups, compared to the control group. Conclusion: The no-adverse-effect-level for LPE and LLP is (1000 mg/kg/day) when administered orally for 28 days.
format Indexed Article
author Ahmed Saeed, Mohammed Ali
Memon, Abdul Hakeem
Hamil, Mohd Shahrul Ridzuan
Hooi, Kheng Beh
Mohammed Saghir, Sultan Ayesh
Kaur, Gurjeet
Sadikun, Amirin
Ismail, Zhari
spellingShingle Ahmed Saeed, Mohammed Ali
Memon, Abdul Hakeem
Hamil, Mohd Shahrul Ridzuan
Hooi, Kheng Beh
Mohammed Saghir, Sultan Ayesh
Kaur, Gurjeet
Sadikun, Amirin
Ismail, Zhari
Toxicity evaluation of standardized and nanoliposomal extracts of Labisia pumila whole plant (Blume, Myrsinaceae) in Sprague Dawley rats
author_facet Ahmed Saeed, Mohammed Ali
Memon, Abdul Hakeem
Hamil, Mohd Shahrul Ridzuan
Hooi, Kheng Beh
Mohammed Saghir, Sultan Ayesh
Kaur, Gurjeet
Sadikun, Amirin
Ismail, Zhari
author_sort Ahmed Saeed, Mohammed Ali
title Toxicity evaluation of standardized and nanoliposomal extracts of Labisia pumila whole plant (Blume, Myrsinaceae) in Sprague Dawley rats
title_short Toxicity evaluation of standardized and nanoliposomal extracts of Labisia pumila whole plant (Blume, Myrsinaceae) in Sprague Dawley rats
title_full Toxicity evaluation of standardized and nanoliposomal extracts of Labisia pumila whole plant (Blume, Myrsinaceae) in Sprague Dawley rats
title_fullStr Toxicity evaluation of standardized and nanoliposomal extracts of Labisia pumila whole plant (Blume, Myrsinaceae) in Sprague Dawley rats
title_full_unstemmed Toxicity evaluation of standardized and nanoliposomal extracts of Labisia pumila whole plant (Blume, Myrsinaceae) in Sprague Dawley rats
title_sort toxicity evaluation of standardized and nanoliposomal extracts of labisia pumila whole plant (blume, myrsinaceae) in sprague dawley rats
publishDate 2018
url http://discol.umk.edu.my/id/eprint/7330/1/Toxicity%20evaluation%20of%20standardized%20and%20nanoliposomal%20extracts%20of%20Labisia%20pumila%20whole%20plant%20%28Blume%2C%20Myrsinaceae%29%20in%20Sprague%20Dawley%20rats.pdf
http://discol.umk.edu.my/id/eprint/7330/
https://www.ajol.info/index.php/tjpr/article/view/178173
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score 13.211869

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