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Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia

We refer to the article by Merican, which provides a comprehensive overview of chronic hepatitis C (CHC) management. The author highlighted the concern over the exorbitant cost of direct-acting antivirals, which is the reason for their limited use in Malaysia currently. Based on the findings of the...

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Main Authors: Chee-Hoong, Hoe, Mohd Suan, Mohd Azri, Chee-Hock, Hoe, Thean-Hock Tang, Tang, Kuang-Kiat, Kiew, Abu Hassan, Muhammad Radzi, Huan-Keat, Chan
Format: Indexed Article
Language:English
Published: 2018
Online Access:http://discol.umk.edu.my/id/eprint/7312/1/interleukin.pdf
http://discol.umk.edu.my/id/eprint/7312/
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spelling my.umk.eprints.73122022-05-23T09:56:25Z http://discol.umk.edu.my/id/eprint/7312/ Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia Chee-Hoong, Hoe Mohd Suan, Mohd Azri Chee-Hock, Hoe Thean-Hock Tang, Tang Kuang-Kiat, Kiew Abu Hassan, Muhammad Radzi Huan-Keat, Chan We refer to the article by Merican, which provides a comprehensive overview of chronic hepatitis C (CHC) management. The author highlighted the concern over the exorbitant cost of direct-acting antivirals, which is the reason for their limited use in Malaysia currently. Based on the findings of the previous studies, the author also underlined that Asians receiving the conventional, interferon-based treatment generally have a higher sustained virological response (SVR) rate as compared with Caucasians and African Americans, mainly due to the interleukin-28B (IL28) single nucleotide polymorphism (SNP) across different ethnic populations. Nonetheless, to date, information on the variations in IL-28 genotypes among different ethnic groups in Malaysia is still limited. 2018-04-01 Indexed Article NonPeerReviewed text en http://discol.umk.edu.my/id/eprint/7312/1/interleukin.pdf Chee-Hoong, Hoe and Mohd Suan, Mohd Azri and Chee-Hock, Hoe and Thean-Hock Tang, Tang and Kuang-Kiat, Kiew and Abu Hassan, Muhammad Radzi and Huan-Keat, Chan (2018) Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia. Medical Journal of Malaysia, 73 (4). p. 1. ISSN 3005283
institution Universiti Malaysia Kelantan
building Perpustakaan Universiti Malaysia Kelantan
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Kelantan
content_source UMK Institutional Repository
url_provider http://umkeprints.umk.edu.my/
language English
description We refer to the article by Merican, which provides a comprehensive overview of chronic hepatitis C (CHC) management. The author highlighted the concern over the exorbitant cost of direct-acting antivirals, which is the reason for their limited use in Malaysia currently. Based on the findings of the previous studies, the author also underlined that Asians receiving the conventional, interferon-based treatment generally have a higher sustained virological response (SVR) rate as compared with Caucasians and African Americans, mainly due to the interleukin-28B (IL28) single nucleotide polymorphism (SNP) across different ethnic populations. Nonetheless, to date, information on the variations in IL-28 genotypes among different ethnic groups in Malaysia is still limited.
format Indexed Article
author Chee-Hoong, Hoe
Mohd Suan, Mohd Azri
Chee-Hock, Hoe
Thean-Hock Tang, Tang
Kuang-Kiat, Kiew
Abu Hassan, Muhammad Radzi
Huan-Keat, Chan
spellingShingle Chee-Hoong, Hoe
Mohd Suan, Mohd Azri
Chee-Hock, Hoe
Thean-Hock Tang, Tang
Kuang-Kiat, Kiew
Abu Hassan, Muhammad Radzi
Huan-Keat, Chan
Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia
author_facet Chee-Hoong, Hoe
Mohd Suan, Mohd Azri
Chee-Hock, Hoe
Thean-Hock Tang, Tang
Kuang-Kiat, Kiew
Abu Hassan, Muhammad Radzi
Huan-Keat, Chan
author_sort Chee-Hoong, Hoe
title Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia
title_short Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia
title_full Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia
title_fullStr Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia
title_full_unstemmed Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia
title_sort interleukin-28 polymorphism: ethnic variations and the response to chronic hepatitis c treatment in malaysia
publishDate 2018
url http://discol.umk.edu.my/id/eprint/7312/1/interleukin.pdf
http://discol.umk.edu.my/id/eprint/7312/
_version_ 1763303823382675456
score 13.211869

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