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Effect of low level laser and low intensity pulsed ultrasound therapy on bone remodeling during orthodontic tooth movement in rats

Background: Quality bone regeneration, which leads to the improvement of bone remodeling, is essential for orthodontic treatment. In order to improve bone regeneration and increase the amount of tooth movement, different techniques have been implemented. The object of this study is to compare the ef...

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Main Authors: Mahmood Jawad Alazzawi, Mohammed, Husein, Adam, Alam, Mohammad Khursheed, Hassan, Rozita, Shaari, Rumaizi, Azlina, Ahmad, M. S., Salzihan
Format: Indexed Article
Language:English
Published: Springer 2018
Online Access:http://discol.umk.edu.my/id/eprint/7311/1/Effect%20of%20low%20level%20laser%20and%20low%20intensity.pdf
http://discol.umk.edu.my/id/eprint/7311/
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spelling my.umk.eprints.73112022-05-23T15:52:38Z http://discol.umk.edu.my/id/eprint/7311/ Effect of low level laser and low intensity pulsed ultrasound therapy on bone remodeling during orthodontic tooth movement in rats Mahmood Jawad Alazzawi, Mohammed Husein, Adam Alam, Mohammad Khursheed Hassan, Rozita Shaari, Rumaizi Azlina, Ahmad M. S., Salzihan Background: Quality bone regeneration, which leads to the improvement of bone remodeling, is essential for orthodontic treatment. In order to improve bone regeneration and increase the amount of tooth movement, different techniques have been implemented. The object of this study is to compare the effects of low-level laser therapy (LLLT), low-intensity pulsed ultrasound (LIPUS), and their combination on bone remodeling during orthodontic tooth movement. Methods: Eighty (80) male, 6-week-old Sprague Dawley rats were grouped in to four groups, the first group was irradiated with (940 nm) diode laser, second group with LIPUS, and third group with combination of both LLLT and LIPUS. A forth group used was a control group in an incomplete block split-mouth design. The LLLT and LIPUS were used to treat the area around the moving tooth once a day on days 0–7, then the experiment was ended in each experimental endpoint (1, 3, 7, 14, and 21 days). For amount of tooth movement, models were imaged and analyzed. Histological examination was performed after staining with (hematoxylin and eosin) and (alizarin red and Alcian Blue) stain. One step reverse transcription-polymerase chain reaction RT-PCR was also performed to elucidate the gene expression of RANK, RANKL, OPG, and RUNX-2. Results: The amount of tooth movement, the histological bone remodeling, and the RT-PCR were significantly greater in the treatment groups than that in the control group. Among the treatment groups, the combination group was the highest and the LIPUS group was the lowest. Conclusion: These findings suggest that LLLT and LIPUS can enhance the velocity of tooth movement and improve the quality of bone remodeling during orthodontic tooth movement. Springer 2018-04-16 Indexed Article NonPeerReviewed text en http://discol.umk.edu.my/id/eprint/7311/1/Effect%20of%20low%20level%20laser%20and%20low%20intensity.pdf Mahmood Jawad Alazzawi, Mohammed and Husein, Adam and Alam, Mohammad Khursheed and Hassan, Rozita and Shaari, Rumaizi and Azlina, Ahmad and M. S., Salzihan (2018) Effect of low level laser and low intensity pulsed ultrasound therapy on bone remodeling during orthodontic tooth movement in rats. Progress in Orthodontics, 19 (10). pp. 1-11. ISSN 2196-1042
institution Universiti Malaysia Kelantan
building Perpustakaan Universiti Malaysia Kelantan
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Kelantan
content_source UMK Institutional Repository
url_provider http://umkeprints.umk.edu.my/
language English
description Background: Quality bone regeneration, which leads to the improvement of bone remodeling, is essential for orthodontic treatment. In order to improve bone regeneration and increase the amount of tooth movement, different techniques have been implemented. The object of this study is to compare the effects of low-level laser therapy (LLLT), low-intensity pulsed ultrasound (LIPUS), and their combination on bone remodeling during orthodontic tooth movement. Methods: Eighty (80) male, 6-week-old Sprague Dawley rats were grouped in to four groups, the first group was irradiated with (940 nm) diode laser, second group with LIPUS, and third group with combination of both LLLT and LIPUS. A forth group used was a control group in an incomplete block split-mouth design. The LLLT and LIPUS were used to treat the area around the moving tooth once a day on days 0–7, then the experiment was ended in each experimental endpoint (1, 3, 7, 14, and 21 days). For amount of tooth movement, models were imaged and analyzed. Histological examination was performed after staining with (hematoxylin and eosin) and (alizarin red and Alcian Blue) stain. One step reverse transcription-polymerase chain reaction RT-PCR was also performed to elucidate the gene expression of RANK, RANKL, OPG, and RUNX-2. Results: The amount of tooth movement, the histological bone remodeling, and the RT-PCR were significantly greater in the treatment groups than that in the control group. Among the treatment groups, the combination group was the highest and the LIPUS group was the lowest. Conclusion: These findings suggest that LLLT and LIPUS can enhance the velocity of tooth movement and improve the quality of bone remodeling during orthodontic tooth movement.
format Indexed Article
author Mahmood Jawad Alazzawi, Mohammed
Husein, Adam
Alam, Mohammad Khursheed
Hassan, Rozita
Shaari, Rumaizi
Azlina, Ahmad
M. S., Salzihan
spellingShingle Mahmood Jawad Alazzawi, Mohammed
Husein, Adam
Alam, Mohammad Khursheed
Hassan, Rozita
Shaari, Rumaizi
Azlina, Ahmad
M. S., Salzihan
Effect of low level laser and low intensity pulsed ultrasound therapy on bone remodeling during orthodontic tooth movement in rats
author_facet Mahmood Jawad Alazzawi, Mohammed
Husein, Adam
Alam, Mohammad Khursheed
Hassan, Rozita
Shaari, Rumaizi
Azlina, Ahmad
M. S., Salzihan
author_sort Mahmood Jawad Alazzawi, Mohammed
title Effect of low level laser and low intensity pulsed ultrasound therapy on bone remodeling during orthodontic tooth movement in rats
title_short Effect of low level laser and low intensity pulsed ultrasound therapy on bone remodeling during orthodontic tooth movement in rats
title_full Effect of low level laser and low intensity pulsed ultrasound therapy on bone remodeling during orthodontic tooth movement in rats
title_fullStr Effect of low level laser and low intensity pulsed ultrasound therapy on bone remodeling during orthodontic tooth movement in rats
title_full_unstemmed Effect of low level laser and low intensity pulsed ultrasound therapy on bone remodeling during orthodontic tooth movement in rats
title_sort effect of low level laser and low intensity pulsed ultrasound therapy on bone remodeling during orthodontic tooth movement in rats
publisher Springer
publishDate 2018
url http://discol.umk.edu.my/id/eprint/7311/1/Effect%20of%20low%20level%20laser%20and%20low%20intensity.pdf
http://discol.umk.edu.my/id/eprint/7311/
_version_ 1763303823240069120
score 13.211869

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