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Development and characterization of Nanocream containing Dukung Anak (Phyllanthus niruri Linn.) Oil for antimicrobial activities

Crushed leaves of Phyllathus niruri is used in traditional medicine practice for the treatment of skin disease. The essential oil from Phyllanthus niruri contains aqueous and ethanol solution extracts that has antimicrobial, anti-fungal and anti-inflammatory properties. Therefore, the objective of t...

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Main Author: Safiee, Surayah
Format: Undergraduate Final Project Report
Published: 2019
Online Access:http://discol.umk.edu.my/id/eprint/4793/
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spelling my.umk.eprints.47932022-05-23T08:34:43Z http://discol.umk.edu.my/id/eprint/4793/ Development and characterization of Nanocream containing Dukung Anak (Phyllanthus niruri Linn.) Oil for antimicrobial activities Safiee, Surayah Crushed leaves of Phyllathus niruri is used in traditional medicine practice for the treatment of skin disease. The essential oil from Phyllanthus niruri contains aqueous and ethanol solution extracts that has antimicrobial, anti-fungal and anti-inflammatory properties. Therefore, the objective of this study is to formulate, prepare, and characterize the Phyllanthus niruri oil nanocream using an analytical standard palm oil. The nanocream base was formulated using different ratios of oil, surfactants and water. Surfactants used were mixture of Tween 80 and Span 65 at different ratios. Four formulations using mixtures of Tween 80 and Span 65 were further evaluated for accelerated stability test, droplet size and physical appearance of viscosity. The nanocream base which had an average droplet size of 100 nm to 600 nm, a plastic flow with thixotropic behavior and not separate after centrifuge process was selected for incorporation of 2 % and 4 % of Phyllanthus niruri oil. Meanwhile, this study also to investigate the antimicrobial activities of nanocream by agar diffusion against bacteria (Staphylococcus aureus). However, the organisms display the small zone inhibition at 2 % and 4 % in an average of 0.53 and 0.77 cm. Thus, the results indicate that Phyllanthus niruri oil can be formulated into nanocream for tropical application in treating skin infection. 2019 Undergraduate Final Project Report NonPeerReviewed Safiee, Surayah (2019) Development and characterization of Nanocream containing Dukung Anak (Phyllanthus niruri Linn.) Oil for antimicrobial activities. Final Year Project thesis, Universiti Malaysia Kelantan. (Submitted)
institution Universiti Malaysia Kelantan
building Perpustakaan Universiti Malaysia Kelantan
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Kelantan
content_source UMK Institutional Repository
url_provider http://umkeprints.umk.edu.my/
description Crushed leaves of Phyllathus niruri is used in traditional medicine practice for the treatment of skin disease. The essential oil from Phyllanthus niruri contains aqueous and ethanol solution extracts that has antimicrobial, anti-fungal and anti-inflammatory properties. Therefore, the objective of this study is to formulate, prepare, and characterize the Phyllanthus niruri oil nanocream using an analytical standard palm oil. The nanocream base was formulated using different ratios of oil, surfactants and water. Surfactants used were mixture of Tween 80 and Span 65 at different ratios. Four formulations using mixtures of Tween 80 and Span 65 were further evaluated for accelerated stability test, droplet size and physical appearance of viscosity. The nanocream base which had an average droplet size of 100 nm to 600 nm, a plastic flow with thixotropic behavior and not separate after centrifuge process was selected for incorporation of 2 % and 4 % of Phyllanthus niruri oil. Meanwhile, this study also to investigate the antimicrobial activities of nanocream by agar diffusion against bacteria (Staphylococcus aureus). However, the organisms display the small zone inhibition at 2 % and 4 % in an average of 0.53 and 0.77 cm. Thus, the results indicate that Phyllanthus niruri oil can be formulated into nanocream for tropical application in treating skin infection.
format Undergraduate Final Project Report
author Safiee, Surayah
spellingShingle Safiee, Surayah
Development and characterization of Nanocream containing Dukung Anak (Phyllanthus niruri Linn.) Oil for antimicrobial activities
author_facet Safiee, Surayah
author_sort Safiee, Surayah
title Development and characterization of Nanocream containing Dukung Anak (Phyllanthus niruri Linn.) Oil for antimicrobial activities
title_short Development and characterization of Nanocream containing Dukung Anak (Phyllanthus niruri Linn.) Oil for antimicrobial activities
title_full Development and characterization of Nanocream containing Dukung Anak (Phyllanthus niruri Linn.) Oil for antimicrobial activities
title_fullStr Development and characterization of Nanocream containing Dukung Anak (Phyllanthus niruri Linn.) Oil for antimicrobial activities
title_full_unstemmed Development and characterization of Nanocream containing Dukung Anak (Phyllanthus niruri Linn.) Oil for antimicrobial activities
title_sort development and characterization of nanocream containing dukung anak (phyllanthus niruri linn.) oil for antimicrobial activities
publishDate 2019
url http://discol.umk.edu.my/id/eprint/4793/
_version_ 1763303463704330240
score 13.211869

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