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Preparation of Hydrogel Films of Sodium Alginate and Gelatin with Aloe Vera via solvent casting and cross-linking method

Nowadays, the development of modern hydrogel films by natural polymer materials are increasing for wound healing purpose as they are less adhesion to wound site and have anti-inflammatory property as well as proliferation of fibroblast which can accelerate wound healing process gradually. Therefore,...

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Main Author: Ang, Kar Moon
Format: Undergraduate Final Project Report
Published: 2019
Online Access:http://discol.umk.edu.my/id/eprint/4448/
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spelling my.umk.eprints.44482022-05-23T08:27:15Z http://discol.umk.edu.my/id/eprint/4448/ Preparation of Hydrogel Films of Sodium Alginate and Gelatin with Aloe Vera via solvent casting and cross-linking method Ang, Kar Moon Nowadays, the development of modern hydrogel films by natural polymer materials are increasing for wound healing purpose as they are less adhesion to wound site and have anti-inflammatory property as well as proliferation of fibroblast which can accelerate wound healing process gradually. Therefore, this research was aimed to prepare hydrogel films of sodium alginate and gelatin with different proportion of aloe gel using solvent casting and cross-linking methods. The physical and chemical properties of both films with and without cross-linking process were characterized. Based on the results, thicknesses of both Aloe films with and without cross-linking were decreasing when aloe gel increased. Aloe films have higher moisture content than AloeC films which might probably due to cross-linking with calcium chloride has lead to a protection to prevent water molecules evaporated from films. According to FT-IR spectrum shown, the presence of glycine of gelatin and mannose in aloe vera can be detected while existing of acemannan cannot. Alteration absorption band indicated presence of crosslinking network in AloeC films. FT-IR result also showed the absence of acemannan in Aloe films and AloeC films. The swelling ratio showed that both Aloe films and AloeC films have high water uptake at pH 7.2. Among all the films, Aloe5 may has the potential undergoes further processing to form commercially freeze-dried wound healing products due to its uniform size, hydrated content, and slower rate of water absorption. 2019 Undergraduate Final Project Report NonPeerReviewed Ang, Kar Moon (2019) Preparation of Hydrogel Films of Sodium Alginate and Gelatin with Aloe Vera via solvent casting and cross-linking method. Final Year Project thesis, Universiti Malaysia Kelantan. (Submitted)
institution Universiti Malaysia Kelantan
building Perpustakaan Universiti Malaysia Kelantan
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Kelantan
content_source UMK Institutional Repository
url_provider http://umkeprints.umk.edu.my/
description Nowadays, the development of modern hydrogel films by natural polymer materials are increasing for wound healing purpose as they are less adhesion to wound site and have anti-inflammatory property as well as proliferation of fibroblast which can accelerate wound healing process gradually. Therefore, this research was aimed to prepare hydrogel films of sodium alginate and gelatin with different proportion of aloe gel using solvent casting and cross-linking methods. The physical and chemical properties of both films with and without cross-linking process were characterized. Based on the results, thicknesses of both Aloe films with and without cross-linking were decreasing when aloe gel increased. Aloe films have higher moisture content than AloeC films which might probably due to cross-linking with calcium chloride has lead to a protection to prevent water molecules evaporated from films. According to FT-IR spectrum shown, the presence of glycine of gelatin and mannose in aloe vera can be detected while existing of acemannan cannot. Alteration absorption band indicated presence of crosslinking network in AloeC films. FT-IR result also showed the absence of acemannan in Aloe films and AloeC films. The swelling ratio showed that both Aloe films and AloeC films have high water uptake at pH 7.2. Among all the films, Aloe5 may has the potential undergoes further processing to form commercially freeze-dried wound healing products due to its uniform size, hydrated content, and slower rate of water absorption.
format Undergraduate Final Project Report
author Ang, Kar Moon
spellingShingle Ang, Kar Moon
Preparation of Hydrogel Films of Sodium Alginate and Gelatin with Aloe Vera via solvent casting and cross-linking method
author_facet Ang, Kar Moon
author_sort Ang, Kar Moon
title Preparation of Hydrogel Films of Sodium Alginate and Gelatin with Aloe Vera via solvent casting and cross-linking method
title_short Preparation of Hydrogel Films of Sodium Alginate and Gelatin with Aloe Vera via solvent casting and cross-linking method
title_full Preparation of Hydrogel Films of Sodium Alginate and Gelatin with Aloe Vera via solvent casting and cross-linking method
title_fullStr Preparation of Hydrogel Films of Sodium Alginate and Gelatin with Aloe Vera via solvent casting and cross-linking method
title_full_unstemmed Preparation of Hydrogel Films of Sodium Alginate and Gelatin with Aloe Vera via solvent casting and cross-linking method
title_sort preparation of hydrogel films of sodium alginate and gelatin with aloe vera via solvent casting and cross-linking method
publishDate 2019
url http://discol.umk.edu.my/id/eprint/4448/
_version_ 1763303415610343424
score 13.211869

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