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Acute Dermal Toxicological Study Of Chitosan/Polyvinyl Alcohol/Sodium Alginate Composite Film Loaded With Gynura Procumbens Extract As Potential Biofilm Plaster For Wound Healing

An abstract of the research paper presented to the Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, in partial requirement of the course DVT 55204 – Research Project. This research sought to study the effects of novel biofilm containing Gynura procumbens, sodium alginate, chitosan, an...

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Main Author: Brady Joshua A/L Kodimani
Format: Undergraduate Final Project Report
Language:English
Published: 2025
Online Access:http://discol.umk.edu.my/id/eprint/14873/1/BRADY%20JOSHUA%20D20A0094.pdf
http://discol.umk.edu.my/id/eprint/14873/
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spelling my.umk.eprints.148732025-03-02T06:55:16Z http://discol.umk.edu.my/id/eprint/14873/ Acute Dermal Toxicological Study Of Chitosan/Polyvinyl Alcohol/Sodium Alginate Composite Film Loaded With Gynura Procumbens Extract As Potential Biofilm Plaster For Wound Healing Brady Joshua A/L Kodimani An abstract of the research paper presented to the Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, in partial requirement of the course DVT 55204 – Research Project. This research sought to study the effects of novel biofilm containing Gynura procumbens, sodium alginate, chitosan, and PVA as prospective for wound dressings. The three different biofilms were constructed using solvent casting method and Soxhlet extraction method. Gynura procumbens extracts were incorporated in every biofilm. Each biofilm characterization includes the investigation of Acute Dermal Toxicity, Hematological analysis and histopathology. All rats were observed for any alterations in their physical characteristics and behavioural patterns that might arise as a result of the plant's toxic effects during the 14-day study period. Overall, the findings show that all three biofilms with Gynura procumbens extract equipped with chitosan, PVA, and sodium alginate-based films have promising potential as plasters for wound treatment in the future. The minimal changes that the biofilm caused indicates a new plausible plaster to be refined. The study emphasizes on the important aspects of appropriate film synthesis and presence of dermal and systemic toxicity that could pave a path for future development of wound healing plasters. Setting a foundation for further investigation and improvement for biofilms enhanced with Gynura procumbens for therapeutic applications, this research advances a potential for a new novel pharmaceutical product. Keywords: Acute Dermal Toxicity, Polymer Based biofilm, Gynura procumbens, Wound healing plaster. 2025-02-13 Undergraduate Final Project Report NonPeerReviewed text en http://discol.umk.edu.my/id/eprint/14873/1/BRADY%20JOSHUA%20D20A0094.pdf Brady Joshua A/L Kodimani (2025) Acute Dermal Toxicological Study Of Chitosan/Polyvinyl Alcohol/Sodium Alginate Composite Film Loaded With Gynura Procumbens Extract As Potential Biofilm Plaster For Wound Healing. Final Year Project thesis, Universiti Malaysia Kelantan. (Submitted)
institution Universiti Malaysia Kelantan
building Perpustakaan Universiti Malaysia Kelantan
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Kelantan
content_source UMK Institutional Repository
url_provider http://umkeprints.umk.edu.my/
language English
description An abstract of the research paper presented to the Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, in partial requirement of the course DVT 55204 – Research Project. This research sought to study the effects of novel biofilm containing Gynura procumbens, sodium alginate, chitosan, and PVA as prospective for wound dressings. The three different biofilms were constructed using solvent casting method and Soxhlet extraction method. Gynura procumbens extracts were incorporated in every biofilm. Each biofilm characterization includes the investigation of Acute Dermal Toxicity, Hematological analysis and histopathology. All rats were observed for any alterations in their physical characteristics and behavioural patterns that might arise as a result of the plant's toxic effects during the 14-day study period. Overall, the findings show that all three biofilms with Gynura procumbens extract equipped with chitosan, PVA, and sodium alginate-based films have promising potential as plasters for wound treatment in the future. The minimal changes that the biofilm caused indicates a new plausible plaster to be refined. The study emphasizes on the important aspects of appropriate film synthesis and presence of dermal and systemic toxicity that could pave a path for future development of wound healing plasters. Setting a foundation for further investigation and improvement for biofilms enhanced with Gynura procumbens for therapeutic applications, this research advances a potential for a new novel pharmaceutical product. Keywords: Acute Dermal Toxicity, Polymer Based biofilm, Gynura procumbens, Wound healing plaster.
format Undergraduate Final Project Report
author Brady Joshua A/L Kodimani
spellingShingle Brady Joshua A/L Kodimani
Acute Dermal Toxicological Study Of Chitosan/Polyvinyl Alcohol/Sodium Alginate Composite Film Loaded With Gynura Procumbens Extract As Potential Biofilm Plaster For Wound Healing
author_facet Brady Joshua A/L Kodimani
author_sort Brady Joshua A/L Kodimani
title Acute Dermal Toxicological Study Of Chitosan/Polyvinyl Alcohol/Sodium Alginate Composite Film Loaded With Gynura Procumbens Extract As Potential Biofilm Plaster For Wound Healing
title_short Acute Dermal Toxicological Study Of Chitosan/Polyvinyl Alcohol/Sodium Alginate Composite Film Loaded With Gynura Procumbens Extract As Potential Biofilm Plaster For Wound Healing
title_full Acute Dermal Toxicological Study Of Chitosan/Polyvinyl Alcohol/Sodium Alginate Composite Film Loaded With Gynura Procumbens Extract As Potential Biofilm Plaster For Wound Healing
title_fullStr Acute Dermal Toxicological Study Of Chitosan/Polyvinyl Alcohol/Sodium Alginate Composite Film Loaded With Gynura Procumbens Extract As Potential Biofilm Plaster For Wound Healing
title_full_unstemmed Acute Dermal Toxicological Study Of Chitosan/Polyvinyl Alcohol/Sodium Alginate Composite Film Loaded With Gynura Procumbens Extract As Potential Biofilm Plaster For Wound Healing
title_sort acute dermal toxicological study of chitosan/polyvinyl alcohol/sodium alginate composite film loaded with gynura procumbens extract as potential biofilm plaster for wound healing
publishDate 2025
url http://discol.umk.edu.my/id/eprint/14873/1/BRADY%20JOSHUA%20D20A0094.pdf
http://discol.umk.edu.my/id/eprint/14873/
_version_ 1825819298761801728
score 13.244413

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