Cover Image

Deciphering the immunomodulatory and growth performance effects of trichanthera Gigantea extract adjuvanted chitosan in broiler chicken

Poultry industry in our country is confronting the problem of food safety and security where there is a threat of antimicrobial resistance with drug residue and the rise of the feed price over the past few years. Hence, as an alternative, an investigation using Trichanthera gigantea extract adjuvant...

Full description

Saved in:
Bibliographic Details
Main Author: Nurin Nazifa Mahazir
Format: Undergraduate Final Project Report
Language:English
Published: 2023
Online Access:http://discol.umk.edu.my/id/eprint/14140/1/D19A0030%20NURIN%20NAZIFA%20BINTI%20MAHAZIR.pdf
http://discol.umk.edu.my/id/eprint/14140/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.umk.eprints.14140
record_format eprints
spelling my.umk.eprints.141402024-05-13T06:20:08Z http://discol.umk.edu.my/id/eprint/14140/ Deciphering the immunomodulatory and growth performance effects of trichanthera Gigantea extract adjuvanted chitosan in broiler chicken Nurin Nazifa Mahazir Poultry industry in our country is confronting the problem of food safety and security where there is a threat of antimicrobial resistance with drug residue and the rise of the feed price over the past few years. Hence, as an alternative, an investigation using Trichanthera gigantea extract adjuvanted chitosan was done to observe the immunomodulatory and growth promoting effect of the formulation. Two days old chick was introduced to 1 mg/ml of Trichanthera gigantea extract adjuvanted chitosan, 1 mg/ml of Trichanthera gigantea extract or 1 mg/ml of chitosan via oral administration as supplementation to the commercial feed. Another group of chicks were kept as negative control and being fed with only commercial feed for 12 days. At the end of the rearing period, 0.2 ml blood was withdrawn for white blood cells (WBC) count and the broiler growth performance was calculated. The formulation created was also tested through cell migration assay on proliferative cells using 4T1 cancer cells as the model. The result revealed significant enhancement of WBC and granulocytes count for all of the experimental group. For growth performance there were no significant findings except for higher specific growth rate in the group receiving 1 mg/ml of Trichanthera gigantea extract compared to the negative control group. Moreover, all of the formulations were able to inhibit the proliferation of the cancer cells in the assay. From the findings, supplementation of with Trichanthera gigantea extract adjuvanted chitosan is able to stimulate the immune response in broiler chicken and can be potentially used to reduce usage of antibiotic in feed while opening more opportunities on study of growth promoting effects of the supplementation. Keywords: Trichanthera gigantea extract, chitosan, immunomodulation, growth performance, broiler chicken 2023 Undergraduate Final Project Report NonPeerReviewed text en http://discol.umk.edu.my/id/eprint/14140/1/D19A0030%20NURIN%20NAZIFA%20BINTI%20MAHAZIR.pdf Nurin Nazifa Mahazir (2023) Deciphering the immunomodulatory and growth performance effects of trichanthera Gigantea extract adjuvanted chitosan in broiler chicken. Final Year Project thesis, Universiti Malaysia Kelantan. (Submitted)
institution Universiti Malaysia Kelantan
building Perpustakaan Universiti Malaysia Kelantan
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Kelantan
content_source UMK Institutional Repository
url_provider http://umkeprints.umk.edu.my/
language English
description Poultry industry in our country is confronting the problem of food safety and security where there is a threat of antimicrobial resistance with drug residue and the rise of the feed price over the past few years. Hence, as an alternative, an investigation using Trichanthera gigantea extract adjuvanted chitosan was done to observe the immunomodulatory and growth promoting effect of the formulation. Two days old chick was introduced to 1 mg/ml of Trichanthera gigantea extract adjuvanted chitosan, 1 mg/ml of Trichanthera gigantea extract or 1 mg/ml of chitosan via oral administration as supplementation to the commercial feed. Another group of chicks were kept as negative control and being fed with only commercial feed for 12 days. At the end of the rearing period, 0.2 ml blood was withdrawn for white blood cells (WBC) count and the broiler growth performance was calculated. The formulation created was also tested through cell migration assay on proliferative cells using 4T1 cancer cells as the model. The result revealed significant enhancement of WBC and granulocytes count for all of the experimental group. For growth performance there were no significant findings except for higher specific growth rate in the group receiving 1 mg/ml of Trichanthera gigantea extract compared to the negative control group. Moreover, all of the formulations were able to inhibit the proliferation of the cancer cells in the assay. From the findings, supplementation of with Trichanthera gigantea extract adjuvanted chitosan is able to stimulate the immune response in broiler chicken and can be potentially used to reduce usage of antibiotic in feed while opening more opportunities on study of growth promoting effects of the supplementation. Keywords: Trichanthera gigantea extract, chitosan, immunomodulation, growth performance, broiler chicken
format Undergraduate Final Project Report
author Nurin Nazifa Mahazir
spellingShingle Nurin Nazifa Mahazir
Deciphering the immunomodulatory and growth performance effects of trichanthera Gigantea extract adjuvanted chitosan in broiler chicken
author_facet Nurin Nazifa Mahazir
author_sort Nurin Nazifa Mahazir
title Deciphering the immunomodulatory and growth performance effects of trichanthera Gigantea extract adjuvanted chitosan in broiler chicken
title_short Deciphering the immunomodulatory and growth performance effects of trichanthera Gigantea extract adjuvanted chitosan in broiler chicken
title_full Deciphering the immunomodulatory and growth performance effects of trichanthera Gigantea extract adjuvanted chitosan in broiler chicken
title_fullStr Deciphering the immunomodulatory and growth performance effects of trichanthera Gigantea extract adjuvanted chitosan in broiler chicken
title_full_unstemmed Deciphering the immunomodulatory and growth performance effects of trichanthera Gigantea extract adjuvanted chitosan in broiler chicken
title_sort deciphering the immunomodulatory and growth performance effects of trichanthera gigantea extract adjuvanted chitosan in broiler chicken
publishDate 2023
url http://discol.umk.edu.my/id/eprint/14140/1/D19A0030%20NURIN%20NAZIFA%20BINTI%20MAHAZIR.pdf
http://discol.umk.edu.my/id/eprint/14140/
_version_ 1800731944797863936
score 13.211869

Similar Items