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Formulation and evaluation of thermoresponsive hydrogel loaded with ivermectin for antiparasitic application following mange infestation in cats

An abstract of the research paper was presented to the Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, in partial requirement for the course DVT 55204 – Research Project. Mange infestation in cats, caused by mites, is a health concern that can lead to symptoms such as crusty lesions an...

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Main Author: Syarifah Nur’Izzati Iman Syed Ramli
Format: Undergraduate Final Project Report
Language:English
Published: 2023
Online Access:http://discol.umk.edu.my/id/eprint/14137/1/D19A0033%20SYARIFAH%20NUR%27IZZATI%20IMAN%20BINTI%20SYED%20RAMLI.pdf
http://discol.umk.edu.my/id/eprint/14137/
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spelling my.umk.eprints.141372024-05-13T06:19:17Z http://discol.umk.edu.my/id/eprint/14137/ Formulation and evaluation of thermoresponsive hydrogel loaded with ivermectin for antiparasitic application following mange infestation in cats Syarifah Nur’Izzati Iman Syed Ramli An abstract of the research paper was presented to the Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, in partial requirement for the course DVT 55204 – Research Project. Mange infestation in cats, caused by mites, is a health concern that can lead to symptoms such as crusty lesions and hair loss. One of the current practices is administering ivermectin by injection subcutaneously. Therefore in this study, the effectiveness of a new thermoresponsive hydrogel formulation that includes 1% ivermectin (v/v) as topical ivermectin for treating mange infestations in cats was investigated. The investigation examines six formulations with different polyethene glycol (PEG) concentrations, and assesses their physical properties, gelation temperature (Tgel) analysis, and rheological behaviour. Gelation temperatures reflect sensitivity to PEG concentration, with ivermectin influencing Tgel. Rheological assessments indicate non-Newtonian, pseudoplastic behaviour which is essential for optimising hydrogel dressings. Microscopic examination confirms the presence of Notoedres cati in all cats prior to treatment. Initial visual lesion assessments indicate crusty lesions and alopecia, with consistent scratching behavior. Post-treatment evaluations demonstrate lesion improvement in the treatment group, highlighting the potential of ivermectin-loaded hydrogels as future topical medication. Keywords: Mange infestation, ivermectin, cats, topical treatment, crusty lesion, thermoresponsive hydrogel. 2023 Undergraduate Final Project Report NonPeerReviewed text en http://discol.umk.edu.my/id/eprint/14137/1/D19A0033%20SYARIFAH%20NUR%27IZZATI%20IMAN%20BINTI%20SYED%20RAMLI.pdf Syarifah Nur’Izzati Iman Syed Ramli (2023) Formulation and evaluation of thermoresponsive hydrogel loaded with ivermectin for antiparasitic application following mange infestation in cats. Final Year Project thesis, Universiti Malaysia Kelantan. (Submitted)
institution Universiti Malaysia Kelantan
building Perpustakaan Universiti Malaysia Kelantan
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Kelantan
content_source UMK Institutional Repository
url_provider http://umkeprints.umk.edu.my/
language English
description An abstract of the research paper was presented to the Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, in partial requirement for the course DVT 55204 – Research Project. Mange infestation in cats, caused by mites, is a health concern that can lead to symptoms such as crusty lesions and hair loss. One of the current practices is administering ivermectin by injection subcutaneously. Therefore in this study, the effectiveness of a new thermoresponsive hydrogel formulation that includes 1% ivermectin (v/v) as topical ivermectin for treating mange infestations in cats was investigated. The investigation examines six formulations with different polyethene glycol (PEG) concentrations, and assesses their physical properties, gelation temperature (Tgel) analysis, and rheological behaviour. Gelation temperatures reflect sensitivity to PEG concentration, with ivermectin influencing Tgel. Rheological assessments indicate non-Newtonian, pseudoplastic behaviour which is essential for optimising hydrogel dressings. Microscopic examination confirms the presence of Notoedres cati in all cats prior to treatment. Initial visual lesion assessments indicate crusty lesions and alopecia, with consistent scratching behavior. Post-treatment evaluations demonstrate lesion improvement in the treatment group, highlighting the potential of ivermectin-loaded hydrogels as future topical medication. Keywords: Mange infestation, ivermectin, cats, topical treatment, crusty lesion, thermoresponsive hydrogel.
format Undergraduate Final Project Report
author Syarifah Nur’Izzati Iman Syed Ramli
spellingShingle Syarifah Nur’Izzati Iman Syed Ramli
Formulation and evaluation of thermoresponsive hydrogel loaded with ivermectin for antiparasitic application following mange infestation in cats
author_facet Syarifah Nur’Izzati Iman Syed Ramli
author_sort Syarifah Nur’Izzati Iman Syed Ramli
title Formulation and evaluation of thermoresponsive hydrogel loaded with ivermectin for antiparasitic application following mange infestation in cats
title_short Formulation and evaluation of thermoresponsive hydrogel loaded with ivermectin for antiparasitic application following mange infestation in cats
title_full Formulation and evaluation of thermoresponsive hydrogel loaded with ivermectin for antiparasitic application following mange infestation in cats
title_fullStr Formulation and evaluation of thermoresponsive hydrogel loaded with ivermectin for antiparasitic application following mange infestation in cats
title_full_unstemmed Formulation and evaluation of thermoresponsive hydrogel loaded with ivermectin for antiparasitic application following mange infestation in cats
title_sort formulation and evaluation of thermoresponsive hydrogel loaded with ivermectin for antiparasitic application following mange infestation in cats
publishDate 2023
url http://discol.umk.edu.my/id/eprint/14137/1/D19A0033%20SYARIFAH%20NUR%27IZZATI%20IMAN%20BINTI%20SYED%20RAMLI.pdf
http://discol.umk.edu.my/id/eprint/14137/
_version_ 1800731944349073408
score 13.211869

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