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Antimicrobial potential of leaf extract of Chromolaena Odorata

Since ancient times, medicinal plants have been used widely by people to cure numerous diseases and infections. Biological active compounds such as alkaloids and flavonoids found in these plants are believed to possess antimicrobial properties. Hence, this study was aimed to investigate the antimicr...

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Main Author: Fatin Nadia Abu Bakar
Format: Undergraduate Final Project Report
Language:English
Published: 2022
Online Access:http://discol.umk.edu.my/id/eprint/13446/1/FATIN%20NADIA%20ABU%20BAKAR.pdf
http://discol.umk.edu.my/id/eprint/13446/
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spelling my.umk.eprints.134462023-07-03T07:43:34Z http://discol.umk.edu.my/id/eprint/13446/ Antimicrobial potential of leaf extract of Chromolaena Odorata Fatin Nadia Abu Bakar Since ancient times, medicinal plants have been used widely by people to cure numerous diseases and infections. Biological active compounds such as alkaloids and flavonoids found in these plants are believed to possess antimicrobial properties. Hence, this study was aimed to investigate the antimicrobial potential of leaf extract of Chromolaena odorata isolated from the sequencially solvent extraction which were hexane, chloroform, acetone, ethyl acetate and methanol. The powdered leaves sample of C. odorata was successively extracted with different organic solvents according to the increasing polarity to produce crude extracts. These extracts were then screened for antimicrobial activity against selected Gram-positive and Gram-negative bacteria, viz, Stapylococcus aureus, Methilin-resistant Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Escherichia coli, Klebsiella pheumoniae as well as Yersinia Enterocolitica. The results indicated that the methanol leaf extract of C. odorata had the highest percentage of extraction yield compared to others solvent. Besides, the antimicrobial activities from different extracts indicated that they were easier to inhibit Gram-positive bacteria compared to Gram-negative bacteria due to the different composition of bacterial cell wall. In conclusion, the identification of bioactive compounds responsible for antimicrobial activity of leaf extract of C. odorata can lead to the development of novel antimicrobial agents as medicinal plants have been acknowledged to harbour diverse bioactive compounds. This study will contribute to the development of natural antimicrobial agent that can replace the existing of antibiotic where the bacteria have become resistance to them. 2022 Undergraduate Final Project Report NonPeerReviewed text en http://discol.umk.edu.my/id/eprint/13446/1/FATIN%20NADIA%20ABU%20BAKAR.pdf Fatin Nadia Abu Bakar (2022) Antimicrobial potential of leaf extract of Chromolaena Odorata. Final Year Project thesis, Universiti Malaysia Kelantan. (Submitted)
institution Universiti Malaysia Kelantan
building Perpustakaan Universiti Malaysia Kelantan
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Kelantan
content_source UMK Institutional Repository
url_provider http://umkeprints.umk.edu.my/
language English
description Since ancient times, medicinal plants have been used widely by people to cure numerous diseases and infections. Biological active compounds such as alkaloids and flavonoids found in these plants are believed to possess antimicrobial properties. Hence, this study was aimed to investigate the antimicrobial potential of leaf extract of Chromolaena odorata isolated from the sequencially solvent extraction which were hexane, chloroform, acetone, ethyl acetate and methanol. The powdered leaves sample of C. odorata was successively extracted with different organic solvents according to the increasing polarity to produce crude extracts. These extracts were then screened for antimicrobial activity against selected Gram-positive and Gram-negative bacteria, viz, Stapylococcus aureus, Methilin-resistant Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Escherichia coli, Klebsiella pheumoniae as well as Yersinia Enterocolitica. The results indicated that the methanol leaf extract of C. odorata had the highest percentage of extraction yield compared to others solvent. Besides, the antimicrobial activities from different extracts indicated that they were easier to inhibit Gram-positive bacteria compared to Gram-negative bacteria due to the different composition of bacterial cell wall. In conclusion, the identification of bioactive compounds responsible for antimicrobial activity of leaf extract of C. odorata can lead to the development of novel antimicrobial agents as medicinal plants have been acknowledged to harbour diverse bioactive compounds. This study will contribute to the development of natural antimicrobial agent that can replace the existing of antibiotic where the bacteria have become resistance to them.
format Undergraduate Final Project Report
author Fatin Nadia Abu Bakar
spellingShingle Fatin Nadia Abu Bakar
Antimicrobial potential of leaf extract of Chromolaena Odorata
author_facet Fatin Nadia Abu Bakar
author_sort Fatin Nadia Abu Bakar
title Antimicrobial potential of leaf extract of Chromolaena Odorata
title_short Antimicrobial potential of leaf extract of Chromolaena Odorata
title_full Antimicrobial potential of leaf extract of Chromolaena Odorata
title_fullStr Antimicrobial potential of leaf extract of Chromolaena Odorata
title_full_unstemmed Antimicrobial potential of leaf extract of Chromolaena Odorata
title_sort antimicrobial potential of leaf extract of chromolaena odorata
publishDate 2022
url http://discol.umk.edu.my/id/eprint/13446/1/FATIN%20NADIA%20ABU%20BAKAR.pdf
http://discol.umk.edu.my/id/eprint/13446/
_version_ 1770556692609630208
score 13.211869

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