Staff View: Biological and mechanical performance of TI-6AL-4V implant superplastically embedded with hydroxyapatite in animal / Hidayah Mohd Khalid

Biological and mechanical performance of TI-6AL-4V implant superplastically embedded with hydroxyapatite in animal / Hidayah Mohd Khalid

The bioactivity, biocompatibility and durability of two types of Ti-6Al-4V implants embedded with hydroxyapatite (HA), i.e. superplastic embedment (SPE) and superplastic deformation (SPD) implants are studied and compared with the as-received titanium. The samples were implanted subcutaneously on th...

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Main Author:	Hidayah , Mohd Khalid
Format:	Thesis
Published:	2018
Subjects:	TJ Mechanical engineering and machinery
Online Access:	http://studentsrepo.um.edu.my/9702/2/Hidayah_Mohd_Khalid.pdf http://studentsrepo.um.edu.my/9702/1/Hidayah_Mohd_Khalid_%2D_Thesis.pdf http://studentsrepo.um.edu.my/9702/
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spelling	my.um.stud.97022021-02-16T17:54:42Z Biological and mechanical performance of TI-6AL-4V implant superplastically embedded with hydroxyapatite in animal / Hidayah Mohd Khalid Hidayah , Mohd Khalid TJ Mechanical engineering and machinery The bioactivity, biocompatibility and durability of two types of Ti-6Al-4V implants embedded with hydroxyapatite (HA), i.e. superplastic embedment (SPE) and superplastic deformation (SPD) implants are studied and compared with the as-received titanium. The samples were implanted subcutaneously on the backs of Sprague Dawley (SD) rat models for 1, 5 and 12 weeks. Wear tests were conducted to evaluate the durability of the HA layers. The HA layer thickness for the SPE and SPD samples increased from 249.1±0.6 nm to 874.8±13.7 nm, and from 206.1±5.8 nm to 1162.7±7.9 nm respectively, after 12 weeks of implantation. The SPD sample exhibited much faster growth of newly formed HA compared to SPE. The growth of the newly formed HA was strongly dependent on the degree of HA crystallinity in the initial HA layer. After 12 weeks of implantation, the surface hardness value of the SPE and SPD samples decreased from 661±0.4 HV to 586±1.3 HV and from 585±6.6 HV to 425±86.9 HV respectively. The decrease in surface hardness values was due to the newly formed HA layer that was more porous than the initial HA layer. However, the values were still higher than the substrate surface hardness of 321±28.8 HV. According to a histological evaluation, the SPD sample exhibited the best biocompatibility where the space left by the removed implant was almost completely filled with fibrous tissue. This suggests that more bioactive HA layer accelerated the body system’s response to the SPD sample. The wear test indicates that to some extent both SPE and SPD samples were able to withstand the durability test. The SPD sample adequately strengthened the newly-formed HA layer, indicating the best durability test result. This study confirms that the bioactivity, biocompatibility and durability results demonstrate the potential of the SPD sample for medical implant applications. 2018-09 Thesis NonPeerReviewed application/pdf http://studentsrepo.um.edu.my/9702/2/Hidayah_Mohd_Khalid.pdf application/pdf http://studentsrepo.um.edu.my/9702/1/Hidayah_Mohd_Khalid_%2D_Thesis.pdf Hidayah , Mohd Khalid (2018) Biological and mechanical performance of TI-6AL-4V implant superplastically embedded with hydroxyapatite in animal / Hidayah Mohd Khalid. PhD thesis, University of Malaya. http://studentsrepo.um.edu.my/9702/
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Student Repository
url_provider	http://studentsrepo.um.edu.my/
topic	TJ Mechanical engineering and machinery
spellingShingle	TJ Mechanical engineering and machinery Hidayah , Mohd Khalid Biological and mechanical performance of TI-6AL-4V implant superplastically embedded with hydroxyapatite in animal / Hidayah Mohd Khalid
description	The bioactivity, biocompatibility and durability of two types of Ti-6Al-4V implants embedded with hydroxyapatite (HA), i.e. superplastic embedment (SPE) and superplastic deformation (SPD) implants are studied and compared with the as-received titanium. The samples were implanted subcutaneously on the backs of Sprague Dawley (SD) rat models for 1, 5 and 12 weeks. Wear tests were conducted to evaluate the durability of the HA layers. The HA layer thickness for the SPE and SPD samples increased from 249.1±0.6 nm to 874.8±13.7 nm, and from 206.1±5.8 nm to 1162.7±7.9 nm respectively, after 12 weeks of implantation. The SPD sample exhibited much faster growth of newly formed HA compared to SPE. The growth of the newly formed HA was strongly dependent on the degree of HA crystallinity in the initial HA layer. After 12 weeks of implantation, the surface hardness value of the SPE and SPD samples decreased from 661±0.4 HV to 586±1.3 HV and from 585±6.6 HV to 425±86.9 HV respectively. The decrease in surface hardness values was due to the newly formed HA layer that was more porous than the initial HA layer. However, the values were still higher than the substrate surface hardness of 321±28.8 HV. According to a histological evaluation, the SPD sample exhibited the best biocompatibility where the space left by the removed implant was almost completely filled with fibrous tissue. This suggests that more bioactive HA layer accelerated the body system’s response to the SPD sample. The wear test indicates that to some extent both SPE and SPD samples were able to withstand the durability test. The SPD sample adequately strengthened the newly-formed HA layer, indicating the best durability test result. This study confirms that the bioactivity, biocompatibility and durability results demonstrate the potential of the SPD sample for medical implant applications.
format	Thesis
author	Hidayah , Mohd Khalid
author_facet	Hidayah , Mohd Khalid
author_sort	Hidayah , Mohd Khalid
title	Biological and mechanical performance of TI-6AL-4V implant superplastically embedded with hydroxyapatite in animal / Hidayah Mohd Khalid
title_short	Biological and mechanical performance of TI-6AL-4V implant superplastically embedded with hydroxyapatite in animal / Hidayah Mohd Khalid
title_full	Biological and mechanical performance of TI-6AL-4V implant superplastically embedded with hydroxyapatite in animal / Hidayah Mohd Khalid
title_fullStr	Biological and mechanical performance of TI-6AL-4V implant superplastically embedded with hydroxyapatite in animal / Hidayah Mohd Khalid
title_full_unstemmed	Biological and mechanical performance of TI-6AL-4V implant superplastically embedded with hydroxyapatite in animal / Hidayah Mohd Khalid
title_sort	biological and mechanical performance of ti-6al-4v implant superplastically embedded with hydroxyapatite in animal / hidayah mohd khalid
publishDate	2018
url	http://studentsrepo.um.edu.my/9702/2/Hidayah_Mohd_Khalid.pdf http://studentsrepo.um.edu.my/9702/1/Hidayah_Mohd_Khalid_%2D_Thesis.pdf http://studentsrepo.um.edu.my/9702/
_version_	1738506291837403136
score	13.211869

Biological and mechanical performance of TI-6AL-4V implant superplastically embedded with hydroxyapatite in animal / Hidayah Mohd Khalid

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