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Synthesis and reactions of halogenated stilbenes mediated by Lewis acid and QSAR studies of stilbene analogues / Mohd Fadzli Md Din

A total of nine halogenated stilbenes have been produced by Heck coupling method. Five halogenated stilbenes were then subjected to cytotoxicity test on five cancer cell lines and one normal human cell lines. (E)-N-(2-(3-fluorostyryl)phenyl)acetamide 98 displayed good antiproliferative on some of...

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Main Author: Mohd Fadzli , Md Din
Format: Thesis
Published: 2016
Subjects:
Q Science (General)
Online Access:http://studentsrepo.um.edu.my/9300/1/Mohd_Fadzli_Md_Din.pdf
http://studentsrepo.um.edu.my/9300/5/fadzli.pdf
http://studentsrepo.um.edu.my/9300/
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spelling my.um.stud.93002020-01-18T02:30:46Z Synthesis and reactions of halogenated stilbenes mediated by Lewis acid and QSAR studies of stilbene analogues / Mohd Fadzli Md Din Mohd Fadzli , Md Din Q Science (General) A total of nine halogenated stilbenes have been produced by Heck coupling method. Five halogenated stilbenes were then subjected to cytotoxicity test on five cancer cell lines and one normal human cell lines. (E)-N-(2-(3-fluorostyryl)phenyl)acetamide 98 displayed good antiproliferative on some of the cancer cell lines. Moreover, all the stilbenes did not show any cytotoxicity on the normal human cell line. Investigation on Lewis acid reactions; FeCl3 and SnCl4, were pursued on the halogenated stilbenes and produced imines for the former and indolines for the latter. Products conceived from these reactions were discussed thoroughly. Quantitative structure activity relationship (QSAR) study was done on several stilbene analogues to relate the bioactivity of the estrogen- insensitive breast cancer line with the molecular structure of the stilbene analogues. Three types of QSAR applied on these stilbene analogues were 2D QSAR, 3D QSAR and 3D QSAR pharmacophore. 3D QSAR pharmacophore showed the most promising model in predicting activity of new ligands. 2016-04 Thesis NonPeerReviewed application/pdf http://studentsrepo.um.edu.my/9300/1/Mohd_Fadzli_Md_Din.pdf application/pdf http://studentsrepo.um.edu.my/9300/5/fadzli.pdf Mohd Fadzli , Md Din (2016) Synthesis and reactions of halogenated stilbenes mediated by Lewis acid and QSAR studies of stilbene analogues / Mohd Fadzli Md Din. PhD thesis, University of Malaya. http://studentsrepo.um.edu.my/9300/
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Student Repository
url_provider http://studentsrepo.um.edu.my/
topic Q Science (General)
spellingShingle Q Science (General)
Mohd Fadzli , Md Din
Synthesis and reactions of halogenated stilbenes mediated by Lewis acid and QSAR studies of stilbene analogues / Mohd Fadzli Md Din
description A total of nine halogenated stilbenes have been produced by Heck coupling method. Five halogenated stilbenes were then subjected to cytotoxicity test on five cancer cell lines and one normal human cell lines. (E)-N-(2-(3-fluorostyryl)phenyl)acetamide 98 displayed good antiproliferative on some of the cancer cell lines. Moreover, all the stilbenes did not show any cytotoxicity on the normal human cell line. Investigation on Lewis acid reactions; FeCl3 and SnCl4, were pursued on the halogenated stilbenes and produced imines for the former and indolines for the latter. Products conceived from these reactions were discussed thoroughly. Quantitative structure activity relationship (QSAR) study was done on several stilbene analogues to relate the bioactivity of the estrogen- insensitive breast cancer line with the molecular structure of the stilbene analogues. Three types of QSAR applied on these stilbene analogues were 2D QSAR, 3D QSAR and 3D QSAR pharmacophore. 3D QSAR pharmacophore showed the most promising model in predicting activity of new ligands.
format Thesis
author Mohd Fadzli , Md Din
author_facet Mohd Fadzli , Md Din
author_sort Mohd Fadzli , Md Din
title Synthesis and reactions of halogenated stilbenes mediated by Lewis acid and QSAR studies of stilbene analogues / Mohd Fadzli Md Din
title_short Synthesis and reactions of halogenated stilbenes mediated by Lewis acid and QSAR studies of stilbene analogues / Mohd Fadzli Md Din
title_full Synthesis and reactions of halogenated stilbenes mediated by Lewis acid and QSAR studies of stilbene analogues / Mohd Fadzli Md Din
title_fullStr Synthesis and reactions of halogenated stilbenes mediated by Lewis acid and QSAR studies of stilbene analogues / Mohd Fadzli Md Din
title_full_unstemmed Synthesis and reactions of halogenated stilbenes mediated by Lewis acid and QSAR studies of stilbene analogues / Mohd Fadzli Md Din
title_sort synthesis and reactions of halogenated stilbenes mediated by lewis acid and qsar studies of stilbene analogues / mohd fadzli md din
publishDate 2016
url http://studentsrepo.um.edu.my/9300/1/Mohd_Fadzli_Md_Din.pdf
http://studentsrepo.um.edu.my/9300/5/fadzli.pdf
http://studentsrepo.um.edu.my/9300/
_version_ 1738506248869904384
score 13.211869

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