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Mechanical and biological evaluations of hydroxyapatite composite for orthopedic applications / Saeid Baradaran

Hydroxyapatite (HA) has received wide attention in orthopedics, due to its biocompatibility and osseointegration ability. Despite these advantages, the poor mechanical properties of HA often results in rapid wear and premature fracture of implant. Hence, there is a need to improve the mechanical pro...

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Main Author: Baradaran, Saeid
Format: Thesis
Published: 2015
Subjects:
TA Engineering (General). Civil engineering (General)
Online Access:http://studentsrepo.um.edu.my/5996/1/Saeid_baradaran_final_PhD_thesis.pdf
http://studentsrepo.um.edu.my/5996/
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spelling my.um.stud.59962015-11-07T09:39:25Z Mechanical and biological evaluations of hydroxyapatite composite for orthopedic applications / Saeid Baradaran Baradaran, Saeid TA Engineering (General). Civil engineering (General) Hydroxyapatite (HA) has received wide attention in orthopedics, due to its biocompatibility and osseointegration ability. Despite these advantages, the poor mechanical properties of HA often results in rapid wear and premature fracture of implant. Hence, there is a need to improve the mechanical properties of HA without compromising its biocompatibility. The aim of the current research is to explore the potential of metal ion doping and graphene nanosheets (GNS) as reinforcement to HA for orthopedic implants. HA/reduce graphene oxide (rGO) and Ni doped HA/Graphene nano platelet (GNP) are synthesized by hydrothermal and chemical precipitation and characterized by XRD, FT-IR, EDAX, FESEM and Raman spectroscopy. HA/reduce graphene oxide (rGO) and Ni doped HA/ Graphene nanoplatelet (GNP) powder are solidified by hot iso-static pressing, and investigated for their mechanical and biological behavior. In this aspect, rGO, GNP and metal ions reinforcement improve the mechanical properties of HA for free standing composites. In case of nHA/rGO, the fracture toughness and modulus elasticity improves 40% and 86% by wt.%1.5 GNS and hardness increases 32% by wt.%1.0 GNP in compare to HA. In another case (HA-Ni/GNP), microhardness, fracture toughness and elastic modulus of 6%Ni doped HA were improved 55% , 60% and 121% in 6% doping of Ni and also 75%, 164% and 85% in 1.5Ni6, respectively. Both cases have demonstrated a positive influence on the proliferation, differentiation and matrix mineralization activities of osteoblasts, during in-vitro biocompatibility studies in presence of GNS. 2015 Thesis NonPeerReviewed application/pdf http://studentsrepo.um.edu.my/5996/1/Saeid_baradaran_final_PhD_thesis.pdf Baradaran, Saeid (2015) Mechanical and biological evaluations of hydroxyapatite composite for orthopedic applications / Saeid Baradaran. PhD thesis, University of Malaya. http://studentsrepo.um.edu.my/5996/
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Student Repository
url_provider http://studentsrepo.um.edu.my/
topic TA Engineering (General). Civil engineering (General)
spellingShingle TA Engineering (General). Civil engineering (General)
Baradaran, Saeid
Mechanical and biological evaluations of hydroxyapatite composite for orthopedic applications / Saeid Baradaran
description Hydroxyapatite (HA) has received wide attention in orthopedics, due to its biocompatibility and osseointegration ability. Despite these advantages, the poor mechanical properties of HA often results in rapid wear and premature fracture of implant. Hence, there is a need to improve the mechanical properties of HA without compromising its biocompatibility. The aim of the current research is to explore the potential of metal ion doping and graphene nanosheets (GNS) as reinforcement to HA for orthopedic implants. HA/reduce graphene oxide (rGO) and Ni doped HA/Graphene nano platelet (GNP) are synthesized by hydrothermal and chemical precipitation and characterized by XRD, FT-IR, EDAX, FESEM and Raman spectroscopy. HA/reduce graphene oxide (rGO) and Ni doped HA/ Graphene nanoplatelet (GNP) powder are solidified by hot iso-static pressing, and investigated for their mechanical and biological behavior. In this aspect, rGO, GNP and metal ions reinforcement improve the mechanical properties of HA for free standing composites. In case of nHA/rGO, the fracture toughness and modulus elasticity improves 40% and 86% by wt.%1.5 GNS and hardness increases 32% by wt.%1.0 GNP in compare to HA. In another case (HA-Ni/GNP), microhardness, fracture toughness and elastic modulus of 6%Ni doped HA were improved 55% , 60% and 121% in 6% doping of Ni and also 75%, 164% and 85% in 1.5Ni6, respectively. Both cases have demonstrated a positive influence on the proliferation, differentiation and matrix mineralization activities of osteoblasts, during in-vitro biocompatibility studies in presence of GNS.
format Thesis
author Baradaran, Saeid
author_facet Baradaran, Saeid
author_sort Baradaran, Saeid
title Mechanical and biological evaluations of hydroxyapatite composite for orthopedic applications / Saeid Baradaran
title_short Mechanical and biological evaluations of hydroxyapatite composite for orthopedic applications / Saeid Baradaran
title_full Mechanical and biological evaluations of hydroxyapatite composite for orthopedic applications / Saeid Baradaran
title_fullStr Mechanical and biological evaluations of hydroxyapatite composite for orthopedic applications / Saeid Baradaran
title_full_unstemmed Mechanical and biological evaluations of hydroxyapatite composite for orthopedic applications / Saeid Baradaran
title_sort mechanical and biological evaluations of hydroxyapatite composite for orthopedic applications / saeid baradaran
publishDate 2015
url http://studentsrepo.um.edu.my/5996/1/Saeid_baradaran_final_PhD_thesis.pdf
http://studentsrepo.um.edu.my/5996/
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score 13.211869

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