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Chemical constituents of Aglaia exima / Loong Xe-Min

A preliminary study on the chemical constituents of Aglaia exima was performed. The leaves of Aglaia exima was extracted in three different solvents: hexane, dichloromethane and methanol. The fractionation of the hexane extract of the leaves of Aglaia exima collected in Terengganu led to the isolat...

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Main Author: Loong, Xe-Min
Format: Thesis
Published: 2012
Subjects:
Q Science (General)
QD Chemistry
Online Access:http://studentsrepo.um.edu.my/4460/1/Thesis.pdf
http://studentsrepo.um.edu.my/4460/
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spelling my.um.stud.44602014-10-03T07:15:54Z Chemical constituents of Aglaia exima / Loong Xe-Min Loong, Xe-Min Q Science (General) QD Chemistry A preliminary study on the chemical constituents of Aglaia exima was performed. The leaves of Aglaia exima was extracted in three different solvents: hexane, dichloromethane and methanol. The fractionation of the hexane extract of the leaves of Aglaia exima collected in Terengganu led to the isolation of one new cycloartane triterpenoid; cycloart-24-ene-26-ol-3-one 203 and seven known compounds, which are four cycloartane triterpenoids; 24(E)-cycloart-24-ene-3β,26-diol 199, vaticinone 200, schizandronic acid 201, 24(E)-3β-hydroxycycloart-24-ene-26-al 204, one dammarane triterpenoid; cabraleahydroxylactone 202 and two steroids; β-sitosterol 205 (sterol) and stigmast-5-ene-28-one 207 (sterol). The structures of compounds were analyzed and elucidated by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, infrared spectrometry and X-ray. The hexane, dichloromethane and methanol extracts from leaves of Aglaia exima were subjected to biological activity screening. All isolated compounds were measured in vitro for their cytotoxic activities against eight cancer cell; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, cycloart-24-ene-26-ol-3-one 203, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC50 11.5 μM). 2012 Thesis NonPeerReviewed application/pdf http://studentsrepo.um.edu.my/4460/1/Thesis.pdf Loong, Xe-Min (2012) Chemical constituents of Aglaia exima / Loong Xe-Min. Masters thesis, University of Malaya. http://studentsrepo.um.edu.my/4460/
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Student Repository
url_provider http://studentsrepo.um.edu.my/
topic Q Science (General)
QD Chemistry
spellingShingle Q Science (General)
QD Chemistry
Loong, Xe-Min
Chemical constituents of Aglaia exima / Loong Xe-Min
description A preliminary study on the chemical constituents of Aglaia exima was performed. The leaves of Aglaia exima was extracted in three different solvents: hexane, dichloromethane and methanol. The fractionation of the hexane extract of the leaves of Aglaia exima collected in Terengganu led to the isolation of one new cycloartane triterpenoid; cycloart-24-ene-26-ol-3-one 203 and seven known compounds, which are four cycloartane triterpenoids; 24(E)-cycloart-24-ene-3β,26-diol 199, vaticinone 200, schizandronic acid 201, 24(E)-3β-hydroxycycloart-24-ene-26-al 204, one dammarane triterpenoid; cabraleahydroxylactone 202 and two steroids; β-sitosterol 205 (sterol) and stigmast-5-ene-28-one 207 (sterol). The structures of compounds were analyzed and elucidated by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, infrared spectrometry and X-ray. The hexane, dichloromethane and methanol extracts from leaves of Aglaia exima were subjected to biological activity screening. All isolated compounds were measured in vitro for their cytotoxic activities against eight cancer cell; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, cycloart-24-ene-26-ol-3-one 203, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC50 11.5 μM).
format Thesis
author Loong, Xe-Min
author_facet Loong, Xe-Min
author_sort Loong, Xe-Min
title Chemical constituents of Aglaia exima / Loong Xe-Min
title_short Chemical constituents of Aglaia exima / Loong Xe-Min
title_full Chemical constituents of Aglaia exima / Loong Xe-Min
title_fullStr Chemical constituents of Aglaia exima / Loong Xe-Min
title_full_unstemmed Chemical constituents of Aglaia exima / Loong Xe-Min
title_sort chemical constituents of aglaia exima / loong xe-min
publishDate 2012
url http://studentsrepo.um.edu.my/4460/1/Thesis.pdf
http://studentsrepo.um.edu.my/4460/
_version_ 1738505677555367936
score 13.211869

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