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Self-assembly studies and stability evaluation of branched-chain glycolipid nanoparticles / Syaidatul Atiqah Sazalee

Sugar-based surfactants are more prominent due to their nonionic and bio-based properties. Glycolipids such as alkyl polyglucosides (APGs) are amongst the most popular because they can be found in nature or synthesised from cheap natural resources. This research investigates the liquid crystalline a...

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Main Author: Syaidatul Atiqah , Sazalee
Format: Thesis
Published: 2019
Subjects:
QC Physics
QD Chemistry
Online Access:http://studentsrepo.um.edu.my/11857/1/Saidatul_Atiqah.pdf
http://studentsrepo.um.edu.my/11857/2/Syaidatul_Atiqah.pdf
http://studentsrepo.um.edu.my/11857/
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spelling my.um.stud.118572021-03-22T00:22:41Z Self-assembly studies and stability evaluation of branched-chain glycolipid nanoparticles / Syaidatul Atiqah Sazalee Syaidatul Atiqah , Sazalee QC Physics QD Chemistry Sugar-based surfactants are more prominent due to their nonionic and bio-based properties. Glycolipids such as alkyl polyglucosides (APGs) are amongst the most popular because they can be found in nature or synthesised from cheap natural resources. This research investigates the liquid crystalline and self-assembly properties of a branched-chain glycolipid namely 2-hexyldecyl-β(/α)-D-glucoside (αβ-Glu-OC10C6). The thermotropic and lyotropic liquid crystalline phases were determined using differential scanning calorimetry (DSC), optical polarising microscope (OPM) and small-angle X-ray scattering (SAXS). In dry conditions, -Glu-OC10C6 formed a columnar phase with a focal conic texture, while in a binary aqueous system, -Glu-OC10C6 formed inverse hexagonal dispersion called hexosome. The critical aggregation concentrations (CACs) for the branched-chain glycolipid and when it mixed with nonionic co-surfactants (Tween series: T20, T40, T60 and T80) were investigated by using surface tensiometer. The addition of co-surfactants to the glycolipid dispersions reduced the CAC value of -Glu-OC10C6, which further stabilised the system. The formation of mixed surfactants hexosomes was further investigated in terms of the particle size and morphology by using a particle sizer and a transmission electron microscope (TEM). By using light backscattering measurements for 24 h, the stability of the hexosomes was analysed to determine the destabilisation of the system vis-à-vis particle size variations and particle migration. Furthermore, hexosomes based on the hydrophobic surfactant; -Glu-OC10C6, could be insufficiently stabilised, due to the fact that hydrophilic-lipophilic balance (HLB) of the surfactant preventing the formation of a stable double layer, as previously reported. The stability of αβ-Glu-OC10C6 hexosomes were enhanced via the addition of co-surfactant Tween series, which also subsequently decrease particle sizes, thus increasing stability. Therefore, T80 is the most stable co-surfactant to the -Glu-OC10C6 hexosomes formation compared to other co-surfactant. The findings suggest the branched-chain glycolipid as a possible alternative to nonionic surfactant for drug carrier system applications in the near future. 2019-09 Thesis NonPeerReviewed application/pdf http://studentsrepo.um.edu.my/11857/1/Saidatul_Atiqah.pdf application/pdf http://studentsrepo.um.edu.my/11857/2/Syaidatul_Atiqah.pdf Syaidatul Atiqah , Sazalee (2019) Self-assembly studies and stability evaluation of branched-chain glycolipid nanoparticles / Syaidatul Atiqah Sazalee. Masters thesis, University of Malaya. http://studentsrepo.um.edu.my/11857/
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Student Repository
url_provider http://studentsrepo.um.edu.my/
topic QC Physics
QD Chemistry
spellingShingle QC Physics
QD Chemistry
Syaidatul Atiqah , Sazalee
Self-assembly studies and stability evaluation of branched-chain glycolipid nanoparticles / Syaidatul Atiqah Sazalee
description Sugar-based surfactants are more prominent due to their nonionic and bio-based properties. Glycolipids such as alkyl polyglucosides (APGs) are amongst the most popular because they can be found in nature or synthesised from cheap natural resources. This research investigates the liquid crystalline and self-assembly properties of a branched-chain glycolipid namely 2-hexyldecyl-β(/α)-D-glucoside (αβ-Glu-OC10C6). The thermotropic and lyotropic liquid crystalline phases were determined using differential scanning calorimetry (DSC), optical polarising microscope (OPM) and small-angle X-ray scattering (SAXS). In dry conditions, -Glu-OC10C6 formed a columnar phase with a focal conic texture, while in a binary aqueous system, -Glu-OC10C6 formed inverse hexagonal dispersion called hexosome. The critical aggregation concentrations (CACs) for the branched-chain glycolipid and when it mixed with nonionic co-surfactants (Tween series: T20, T40, T60 and T80) were investigated by using surface tensiometer. The addition of co-surfactants to the glycolipid dispersions reduced the CAC value of -Glu-OC10C6, which further stabilised the system. The formation of mixed surfactants hexosomes was further investigated in terms of the particle size and morphology by using a particle sizer and a transmission electron microscope (TEM). By using light backscattering measurements for 24 h, the stability of the hexosomes was analysed to determine the destabilisation of the system vis-à-vis particle size variations and particle migration. Furthermore, hexosomes based on the hydrophobic surfactant; -Glu-OC10C6, could be insufficiently stabilised, due to the fact that hydrophilic-lipophilic balance (HLB) of the surfactant preventing the formation of a stable double layer, as previously reported. The stability of αβ-Glu-OC10C6 hexosomes were enhanced via the addition of co-surfactant Tween series, which also subsequently decrease particle sizes, thus increasing stability. Therefore, T80 is the most stable co-surfactant to the -Glu-OC10C6 hexosomes formation compared to other co-surfactant. The findings suggest the branched-chain glycolipid as a possible alternative to nonionic surfactant for drug carrier system applications in the near future.
format Thesis
author Syaidatul Atiqah , Sazalee
author_facet Syaidatul Atiqah , Sazalee
author_sort Syaidatul Atiqah , Sazalee
title Self-assembly studies and stability evaluation of branched-chain glycolipid nanoparticles / Syaidatul Atiqah Sazalee
title_short Self-assembly studies and stability evaluation of branched-chain glycolipid nanoparticles / Syaidatul Atiqah Sazalee
title_full Self-assembly studies and stability evaluation of branched-chain glycolipid nanoparticles / Syaidatul Atiqah Sazalee
title_fullStr Self-assembly studies and stability evaluation of branched-chain glycolipid nanoparticles / Syaidatul Atiqah Sazalee
title_full_unstemmed Self-assembly studies and stability evaluation of branched-chain glycolipid nanoparticles / Syaidatul Atiqah Sazalee
title_sort self-assembly studies and stability evaluation of branched-chain glycolipid nanoparticles / syaidatul atiqah sazalee
publishDate 2019
url http://studentsrepo.um.edu.my/11857/1/Saidatul_Atiqah.pdf
http://studentsrepo.um.edu.my/11857/2/Syaidatul_Atiqah.pdf
http://studentsrepo.um.edu.my/11857/
_version_ 1738506537522954240
score 13.211869

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