Cover Image

Nigella sativa and its protective role in oxidative stress and hypertension

Hypertension increases the risk for a variety of cardiovascular diseases, including stroke, coronary artery disease, heart failure, and peripheral vascular disease. The increase in oxidative stress has been associated with the pathogenesis of hypertension. Increase of blood pressure is due to an imb...

Full description

Saved in:
Bibliographic Details
Main Authors: Leong, Xin-Fang, Mustafa, Mohd Rais, Jaarin, K.
Format: Article
Language:English
Published: 2013
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/9814/1/Nigella_sativa_and_its_protective_role.pdf
http://eprints.um.edu.my/9814/
http://www.hindawi.com/journals/ecam/2013/120732/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.um.eprints.9814
record_format eprints
spelling my.um.eprints.98142019-12-18T06:42:29Z http://eprints.um.edu.my/9814/ Nigella sativa and its protective role in oxidative stress and hypertension Leong, Xin-Fang Mustafa, Mohd Rais Jaarin, K. R Medicine Hypertension increases the risk for a variety of cardiovascular diseases, including stroke, coronary artery disease, heart failure, and peripheral vascular disease. The increase in oxidative stress has been associated with the pathogenesis of hypertension. Increase of blood pressure is due to an imbalance between antioxidants defence mechanisms and free radical productions. Excessive production of reactive oxygen species reduces nitric oxide bioavailability leading to an endothelial dysfunction and a subsequent increase in total peripheral resistance. Hypertension can cause few symptoms until it reaches the advanced stage and poses serious health problems with lifelong consequences. Hypertensive patients are required to take drugs for life to control the hypertension and prevent complications. Some of these drugs are expensive and may have adverse reactions. Hence, it is timely to examine scientifically, complimentary therapies that are more effective and with minimal undesirable effects. Nigella sativa (NS) and its active constituents have been documented to exhibit antioxidant, hypotensive, calcium channel blockade and diuretic properties which may contribute to reduce blood pressure. This suggests a potential role of NS in the management of hypertension, and thus more studies should be conducted to evaluate its effectiveness. 2013 Article PeerReviewed application/pdf en http://eprints.um.edu.my/9814/1/Nigella_sativa_and_its_protective_role.pdf Leong, Xin-Fang and Mustafa, Mohd Rais and Jaarin, K. (2013) Nigella sativa and its protective role in oxidative stress and hypertension. Evidence-Based Complementary and Alternative Medicine, 2013. ISSN 1741-427X http://www.hindawi.com/journals/ecam/2013/120732/ 10.1155/2013/120732
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine
spellingShingle R Medicine
Leong, Xin-Fang
Mustafa, Mohd Rais
Jaarin, K.
Nigella sativa and its protective role in oxidative stress and hypertension
description Hypertension increases the risk for a variety of cardiovascular diseases, including stroke, coronary artery disease, heart failure, and peripheral vascular disease. The increase in oxidative stress has been associated with the pathogenesis of hypertension. Increase of blood pressure is due to an imbalance between antioxidants defence mechanisms and free radical productions. Excessive production of reactive oxygen species reduces nitric oxide bioavailability leading to an endothelial dysfunction and a subsequent increase in total peripheral resistance. Hypertension can cause few symptoms until it reaches the advanced stage and poses serious health problems with lifelong consequences. Hypertensive patients are required to take drugs for life to control the hypertension and prevent complications. Some of these drugs are expensive and may have adverse reactions. Hence, it is timely to examine scientifically, complimentary therapies that are more effective and with minimal undesirable effects. Nigella sativa (NS) and its active constituents have been documented to exhibit antioxidant, hypotensive, calcium channel blockade and diuretic properties which may contribute to reduce blood pressure. This suggests a potential role of NS in the management of hypertension, and thus more studies should be conducted to evaluate its effectiveness.
format Article
author Leong, Xin-Fang
Mustafa, Mohd Rais
Jaarin, K.
author_facet Leong, Xin-Fang
Mustafa, Mohd Rais
Jaarin, K.
author_sort Leong, Xin-Fang
title Nigella sativa and its protective role in oxidative stress and hypertension
title_short Nigella sativa and its protective role in oxidative stress and hypertension
title_full Nigella sativa and its protective role in oxidative stress and hypertension
title_fullStr Nigella sativa and its protective role in oxidative stress and hypertension
title_full_unstemmed Nigella sativa and its protective role in oxidative stress and hypertension
title_sort nigella sativa and its protective role in oxidative stress and hypertension
publishDate 2013
url http://eprints.um.edu.my/9814/1/Nigella_sativa_and_its_protective_role.pdf
http://eprints.um.edu.my/9814/
http://www.hindawi.com/journals/ecam/2013/120732/
_version_ 1654960648113618944
score 13.211869

Similar Items