Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy
Objective: To determine the predictors of death in Malaysian HIV-infected patients undergoing antiretroviral therapy (ART). Methods: Data from 845 HIV-infected patients aged 20 years on ART in a large teaching hospital in Malaysia from 1989 to 2009 were analyzed using Kaplan Meier and Cox regression...
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2013
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| Online Access: | http://eprints.um.edu.my/8271/1/Predictors_of_death_in_Malaysia_HIV.pdf http://eprints.um.edu.my/8271/ http://www.sciencedirect.com/science/article/pii/S0091743513000194 |
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my.um.eprints.82712013-08-19T02:10:37Z http://eprints.um.edu.my/8271/ Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy Lubis, R. Bulgiba, A. Kamarulzaman, A. Hairi, N.N. Dahlui, M. Peramalah, D. R Medicine Objective: To determine the predictors of death in Malaysian HIV-infected patients undergoing antiretroviral therapy (ART). Methods: Data from 845 HIV-infected patients aged 20 years on ART in a large teaching hospital in Malaysia from 1989 to 2009 were analyzed using Kaplan Meier and Cox regression analyses. Results: 72.7 of the patients survived. Multivariate Cox regression showed that significant predictors of death were age 50 years (HR 1.76; 95 CI 1.18 2.64), secondary education (HR 3.57; 95 CI 1.12 11.37), tertiary education (HR 3.57; 95 CI 1.0911.70), being unemployed (HR 1.49; 95 CI 1.07 2.09), AIDS on initial presentation (HR 5.75; 95 CI 3.29 10.07), single-drug ART (HR 1.84; 95 CI 1.27, 2.66), double-drug ART (HR 1.63; 95 CI 1.19 2.25) and inability to achieve viral load 50 copies/ml (HR 10.22; 95 CI 7.26 14.37). Conclusion: Every effort needs to be made to ensure that all HIV patients have access to triple drug ART, to lower viral load to 50 copies/ml and to treat HIV patients before they progress to AIDS as these are significant modifiable predictors of death in Malaysian HIV patients. 2013 Article PeerReviewed application/pdf en http://eprints.um.edu.my/8271/1/Predictors_of_death_in_Malaysia_HIV.pdf Lubis, R. and Bulgiba, A. and Kamarulzaman, A. and Hairi, N.N. and Dahlui, M. and Peramalah, D. (2013) Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy. Preventive medicine. ISSN 0091-7435 http://www.sciencedirect.com/science/article/pii/S0091743513000194 10.1016/j.ypmed.2013.01.006 |
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R Medicine Lubis, R. Bulgiba, A. Kamarulzaman, A. Hairi, N.N. Dahlui, M. Peramalah, D. Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy |
| description |
Objective: To determine the predictors of death in Malaysian HIV-infected patients undergoing antiretroviral therapy (ART). Methods: Data from 845 HIV-infected patients aged 20 years on ART in a large teaching hospital in Malaysia from 1989 to 2009 were analyzed using Kaplan Meier and Cox regression analyses. Results: 72.7 of the patients survived. Multivariate Cox regression showed that significant predictors of death were age 50 years (HR 1.76; 95 CI 1.18 2.64), secondary education (HR 3.57; 95 CI 1.12 11.37), tertiary education (HR 3.57; 95 CI 1.0911.70), being unemployed (HR 1.49; 95 CI 1.07 2.09), AIDS on initial presentation (HR 5.75; 95 CI 3.29 10.07), single-drug ART (HR 1.84; 95 CI 1.27, 2.66), double-drug ART (HR 1.63; 95 CI 1.19 2.25) and inability to achieve viral load 50 copies/ml (HR 10.22; 95 CI 7.26 14.37). Conclusion: Every effort needs to be made to ensure that all HIV patients have access to triple drug ART, to lower viral load to 50 copies/ml and to treat HIV patients before they progress to AIDS as these are significant modifiable predictors of death in Malaysian HIV patients. |
| format |
Article |
| author |
Lubis, R. Bulgiba, A. Kamarulzaman, A. Hairi, N.N. Dahlui, M. Peramalah, D. |
| author_facet |
Lubis, R. Bulgiba, A. Kamarulzaman, A. Hairi, N.N. Dahlui, M. Peramalah, D. |
| author_sort |
Lubis, R. |
| title |
Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy |
| title_short |
Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy |
| title_full |
Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy |
| title_fullStr |
Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy |
| title_full_unstemmed |
Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy |
| title_sort |
predictors of death in malaysian hiv-infected patients on anti-retroviral therapy |
| publishDate |
2013 |
| url |
http://eprints.um.edu.my/8271/1/Predictors_of_death_in_Malaysia_HIV.pdf http://eprints.um.edu.my/8271/ http://www.sciencedirect.com/science/article/pii/S0091743513000194 |
| _version_ |
1643688263353892864 |
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13.211869 |