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Robustness of palm kernel oil blend in suppository preparation using acetaminophen as a model drug

Background: Theobroma oil suppository base has good characteristics for the delivery of most drugs, but its polymorphism renders it a difficult medium with which to work. Preparation of suppositories using theobroma oil must be carried out at a temperature below 36 °C to avoid formation of metastab...

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Main Authors: Noordin, M.I., Chung, Lip Yong
Format: Article
Published: SAGE Publications 2007
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/8161/
https://doi.org/10.1177/875512250702300603
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spelling my.um.eprints.81612019-08-02T10:35:19Z http://eprints.um.edu.my/8161/ Robustness of palm kernel oil blend in suppository preparation using acetaminophen as a model drug Noordin, M.I. Chung, Lip Yong R Medicine Background: Theobroma oil suppository base has good characteristics for the delivery of most drugs, but its polymorphism renders it a difficult medium with which to work. Preparation of suppositories using theobroma oil must be carried out at a temperature below 36 °C to avoid formation of metastable polymorphs. Substitutes for theobroma oil are therefore desirable. Objective: To compare the characteristics of theobroma oil- and palm kernel oil blend (PKOB)-based suppositories, each produced by 2 different techniques of preparation. Methods: Theobroma oil and PKOB (consisting of hydrogenated palm kernel oil and hydrogenated palm kernel stearin in an 8:2 ratio, with 5 stearic acid and 5 glyceryl monostearate) were used as a base. Suppositories were prepared by 2 different techniques, with acetaminophen used as the model drug. The standard technique used a water bath to melt the base preparation at 36 °C before incorporation of acetaminophen, while the second technique involved melting the base in an oven at 60 °C. The 2 types of suppositories produced by these techniques were then tested physically for appearance, hardness, liquefaction time, and melting characteristics using differential scanning calorimetry. Results: Satisfactory theobroma oil-based suppositories were produced by the water bath technique at 36 °C, but the oven technique at 60 °C failed to produce a good product. On the other hand, both techniques produced satisfactory PKOB-based suppositories that were similar in both physical and thermal characteristics. Conclusions: PKOB constituted with the above-mentioned ingredients can be exposed to a wider range of temperatures without risk of polymorphism. SAGE Publications 2007 Article PeerReviewed Noordin, M.I. and Chung, Lip Yong (2007) Robustness of palm kernel oil blend in suppository preparation using acetaminophen as a model drug. Journal of Pharmacy Technology, 23 (6). pp. 339-343. ISSN 8755-1225 https://doi.org/10.1177/875512250702300603 doi:10.1177/875512250702300603
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Noordin, M.I.
Chung, Lip Yong
Robustness of palm kernel oil blend in suppository preparation using acetaminophen as a model drug
description Background: Theobroma oil suppository base has good characteristics for the delivery of most drugs, but its polymorphism renders it a difficult medium with which to work. Preparation of suppositories using theobroma oil must be carried out at a temperature below 36 °C to avoid formation of metastable polymorphs. Substitutes for theobroma oil are therefore desirable. Objective: To compare the characteristics of theobroma oil- and palm kernel oil blend (PKOB)-based suppositories, each produced by 2 different techniques of preparation. Methods: Theobroma oil and PKOB (consisting of hydrogenated palm kernel oil and hydrogenated palm kernel stearin in an 8:2 ratio, with 5 stearic acid and 5 glyceryl monostearate) were used as a base. Suppositories were prepared by 2 different techniques, with acetaminophen used as the model drug. The standard technique used a water bath to melt the base preparation at 36 °C before incorporation of acetaminophen, while the second technique involved melting the base in an oven at 60 °C. The 2 types of suppositories produced by these techniques were then tested physically for appearance, hardness, liquefaction time, and melting characteristics using differential scanning calorimetry. Results: Satisfactory theobroma oil-based suppositories were produced by the water bath technique at 36 °C, but the oven technique at 60 °C failed to produce a good product. On the other hand, both techniques produced satisfactory PKOB-based suppositories that were similar in both physical and thermal characteristics. Conclusions: PKOB constituted with the above-mentioned ingredients can be exposed to a wider range of temperatures without risk of polymorphism.
format Article
author Noordin, M.I.
Chung, Lip Yong
author_facet Noordin, M.I.
Chung, Lip Yong
author_sort Noordin, M.I.
title Robustness of palm kernel oil blend in suppository preparation using acetaminophen as a model drug
title_short Robustness of palm kernel oil blend in suppository preparation using acetaminophen as a model drug
title_full Robustness of palm kernel oil blend in suppository preparation using acetaminophen as a model drug
title_fullStr Robustness of palm kernel oil blend in suppository preparation using acetaminophen as a model drug
title_full_unstemmed Robustness of palm kernel oil blend in suppository preparation using acetaminophen as a model drug
title_sort robustness of palm kernel oil blend in suppository preparation using acetaminophen as a model drug
publisher SAGE Publications
publishDate 2007
url http://eprints.um.edu.my/8161/
https://doi.org/10.1177/875512250702300603
_version_ 1643688233250324480
score 13.244367

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