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Bioactivity-guided fractionation of the lipoxygenase and cyclooxygenase inhibiting constituents from Chisocheton polyandrus Merr

Lipoxygenase (LOX)-inhibiting compounds from the leaves of Chisocheton polyandrus Merr. were isolated in this study using a bioactivity-guided fractionation technique. Two dammarane triterpenoids, dammara-20,24-dien-3-one (1) (IC50 = 0.69 +/- 0.07 mu M) and 24-hydroxydammara-20,25-dien-3-one (2) (IC...

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Main Authors: Chan, K.Y., Mohamad, K., Ooi, A.J.A., Imiyabir, Z., Chung, L.Y.
Format: Article
Language:English
Published: 2012
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/8153/1/Chan-2012-Bioactivity-guided_f.pdf
http://eprints.um.edu.my/8153/
http://www.sciencedirect.com/science/article/pii/S0367326X12001256
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spelling my.um.eprints.81532013-07-22T00:32:06Z http://eprints.um.edu.my/8153/ Bioactivity-guided fractionation of the lipoxygenase and cyclooxygenase inhibiting constituents from Chisocheton polyandrus Merr Chan, K.Y. Mohamad, K. Ooi, A.J.A. Imiyabir, Z. Chung, L.Y. R Medicine Lipoxygenase (LOX)-inhibiting compounds from the leaves of Chisocheton polyandrus Merr. were isolated in this study using a bioactivity-guided fractionation technique. Two dammarane triterpenoids, dammara-20,24-dien-3-one (1) (IC50 = 0.69 +/- 0.07 mu M) and 24-hydroxydammara-20,25-dien-3-one (2) (IC50 = 1.11 +/- 0.38 mu M), were isolated and identified based on the soybean LOX assay. Dammara-20,24-dien-3-one (1) exhibited dual inhibition of both human 5-LOX (IC50 = 24.27 +/- 2.92 mu M) and cyclooxygenase-2 (COX-2) (IC50 = 3.17 +/- 0.90 mu M), whereas 24-hydroxydammara-20,25-dien-3-one (2) did not exhibit any significant inhibitory effects. This report is the first to detail the inhibition of LOX and COX by both C. polyandrus and its isolated compounds. (C) 2012 Elsevier B.V. All rights reserved. 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/8153/1/Chan-2012-Bioactivity-guided_f.pdf Chan, K.Y. and Mohamad, K. and Ooi, A.J.A. and Imiyabir, Z. and Chung, L.Y. (2012) Bioactivity-guided fractionation of the lipoxygenase and cyclooxygenase inhibiting constituents from Chisocheton polyandrus Merr. Fitoterapia, 83 (5). pp. 961-967. ISSN 0367-326X http://www.sciencedirect.com/science/article/pii/S0367326X12001256 10.1016/j.fitote.2012.04.018
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine
spellingShingle R Medicine
Chan, K.Y.
Mohamad, K.
Ooi, A.J.A.
Imiyabir, Z.
Chung, L.Y.
Bioactivity-guided fractionation of the lipoxygenase and cyclooxygenase inhibiting constituents from Chisocheton polyandrus Merr
description Lipoxygenase (LOX)-inhibiting compounds from the leaves of Chisocheton polyandrus Merr. were isolated in this study using a bioactivity-guided fractionation technique. Two dammarane triterpenoids, dammara-20,24-dien-3-one (1) (IC50 = 0.69 +/- 0.07 mu M) and 24-hydroxydammara-20,25-dien-3-one (2) (IC50 = 1.11 +/- 0.38 mu M), were isolated and identified based on the soybean LOX assay. Dammara-20,24-dien-3-one (1) exhibited dual inhibition of both human 5-LOX (IC50 = 24.27 +/- 2.92 mu M) and cyclooxygenase-2 (COX-2) (IC50 = 3.17 +/- 0.90 mu M), whereas 24-hydroxydammara-20,25-dien-3-one (2) did not exhibit any significant inhibitory effects. This report is the first to detail the inhibition of LOX and COX by both C. polyandrus and its isolated compounds. (C) 2012 Elsevier B.V. All rights reserved.
format Article
author Chan, K.Y.
Mohamad, K.
Ooi, A.J.A.
Imiyabir, Z.
Chung, L.Y.
author_facet Chan, K.Y.
Mohamad, K.
Ooi, A.J.A.
Imiyabir, Z.
Chung, L.Y.
author_sort Chan, K.Y.
title Bioactivity-guided fractionation of the lipoxygenase and cyclooxygenase inhibiting constituents from Chisocheton polyandrus Merr
title_short Bioactivity-guided fractionation of the lipoxygenase and cyclooxygenase inhibiting constituents from Chisocheton polyandrus Merr
title_full Bioactivity-guided fractionation of the lipoxygenase and cyclooxygenase inhibiting constituents from Chisocheton polyandrus Merr
title_fullStr Bioactivity-guided fractionation of the lipoxygenase and cyclooxygenase inhibiting constituents from Chisocheton polyandrus Merr
title_full_unstemmed Bioactivity-guided fractionation of the lipoxygenase and cyclooxygenase inhibiting constituents from Chisocheton polyandrus Merr
title_sort bioactivity-guided fractionation of the lipoxygenase and cyclooxygenase inhibiting constituents from chisocheton polyandrus merr
publishDate 2012
url http://eprints.um.edu.my/8153/1/Chan-2012-Bioactivity-guided_f.pdf
http://eprints.um.edu.my/8153/
http://www.sciencedirect.com/science/article/pii/S0367326X12001256
_version_ 1643688231755055104
score 13.211869

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