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In vitro anticholinergic and antihistaminic activities of acorus calamus linn. Leaves extracts

The present investigation was aimed at determining the effects of hexane, acetone, methanol and aqueous extracts of Acorus calamus leaves (ACHE, ACAE, ACME and ACAQE) on cholinergic and histaminic system using isolated frog rectus abdominis muscle and guinea pig ileum. A dose dependent potentiation...

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Main Authors: Vijayapandi, P., VamsiKrishna, A., SivaNagaSrikanth, B., Vankadari, M., Praveena, B., Ameen, K.M.P., RajendraPrasad, K., Kumarappan, C.T.
Format: Article
Published: 2013
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/8130/
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spelling my.um.eprints.81302013-07-17T00:57:47Z http://eprints.um.edu.my/8130/ In vitro anticholinergic and antihistaminic activities of acorus calamus linn. Leaves extracts Vijayapandi, P. VamsiKrishna, A. SivaNagaSrikanth, B. Vankadari, M. Praveena, B. Ameen, K.M.P. RajendraPrasad, K. Kumarappan, C.T. R Medicine The present investigation was aimed at determining the effects of hexane, acetone, methanol and aqueous extracts of Acorus calamus leaves (ACHE, ACAE, ACME and ACAQE) on cholinergic and histaminic system using isolated frog rectus abdominis muscle and guinea pig ileum. A dose dependent potentiation of Ach response (anticholinesterase like effect) was found with ACAE and ACME at 0.25, 0.5, 0.75 and 1 mg/ml, but at higher dose of ACAE, ACME, ACAQE and ACHE (5, 20 mg/ml) inhibit the Ach response (antinicotinic effect). These results revealed biphasic effect of Acorus calamus leaves extracts on acetylcholine induced contractile response in isolated frog rectus abdominis muscle preparation (i.e. potentiation effect at lower dose and inhibitory effect at higher dose). Studies on isolated guinea pig ileum demonstrated antihistaminic effect in a dose dependent manner (100-1000 mu g/ml) with ACAE, ACME and ACAQE. In addition, the dose dependent inhibition of Ach response (antimuscarinic effect) was observed with ACAE and ACME. In conclusion, Acorus calamus leaves extracts exerts antinicotinic, anticholinesterase like activities in isolated frog rectus abdominis muscle and antihistaminic, antimuscarinic effect in guinea pig ileum. It has been suggested that these observed activities can be further studied for therapeutic potential of Acorus calamus leaves in the treatment of cognitive disorders and asthma. 2013 Article PeerReviewed Vijayapandi, P. and VamsiKrishna, A. and SivaNagaSrikanth, B. and Vankadari, M. and Praveena, B. and Ameen, K.M.P. and RajendraPrasad, K. and Kumarappan, C.T. (2013) In vitro anticholinergic and antihistaminic activities of acorus calamus linn. Leaves extracts. African Journal of Traditional Complementary and Alternative Medicines, 10 (1). pp. 95-101. ISSN 0189-6016
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Vijayapandi, P.
VamsiKrishna, A.
SivaNagaSrikanth, B.
Vankadari, M.
Praveena, B.
Ameen, K.M.P.
RajendraPrasad, K.
Kumarappan, C.T.
In vitro anticholinergic and antihistaminic activities of acorus calamus linn. Leaves extracts
description The present investigation was aimed at determining the effects of hexane, acetone, methanol and aqueous extracts of Acorus calamus leaves (ACHE, ACAE, ACME and ACAQE) on cholinergic and histaminic system using isolated frog rectus abdominis muscle and guinea pig ileum. A dose dependent potentiation of Ach response (anticholinesterase like effect) was found with ACAE and ACME at 0.25, 0.5, 0.75 and 1 mg/ml, but at higher dose of ACAE, ACME, ACAQE and ACHE (5, 20 mg/ml) inhibit the Ach response (antinicotinic effect). These results revealed biphasic effect of Acorus calamus leaves extracts on acetylcholine induced contractile response in isolated frog rectus abdominis muscle preparation (i.e. potentiation effect at lower dose and inhibitory effect at higher dose). Studies on isolated guinea pig ileum demonstrated antihistaminic effect in a dose dependent manner (100-1000 mu g/ml) with ACAE, ACME and ACAQE. In addition, the dose dependent inhibition of Ach response (antimuscarinic effect) was observed with ACAE and ACME. In conclusion, Acorus calamus leaves extracts exerts antinicotinic, anticholinesterase like activities in isolated frog rectus abdominis muscle and antihistaminic, antimuscarinic effect in guinea pig ileum. It has been suggested that these observed activities can be further studied for therapeutic potential of Acorus calamus leaves in the treatment of cognitive disorders and asthma.
format Article
author Vijayapandi, P.
VamsiKrishna, A.
SivaNagaSrikanth, B.
Vankadari, M.
Praveena, B.
Ameen, K.M.P.
RajendraPrasad, K.
Kumarappan, C.T.
author_facet Vijayapandi, P.
VamsiKrishna, A.
SivaNagaSrikanth, B.
Vankadari, M.
Praveena, B.
Ameen, K.M.P.
RajendraPrasad, K.
Kumarappan, C.T.
author_sort Vijayapandi, P.
title In vitro anticholinergic and antihistaminic activities of acorus calamus linn. Leaves extracts
title_short In vitro anticholinergic and antihistaminic activities of acorus calamus linn. Leaves extracts
title_full In vitro anticholinergic and antihistaminic activities of acorus calamus linn. Leaves extracts
title_fullStr In vitro anticholinergic and antihistaminic activities of acorus calamus linn. Leaves extracts
title_full_unstemmed In vitro anticholinergic and antihistaminic activities of acorus calamus linn. Leaves extracts
title_sort in vitro anticholinergic and antihistaminic activities of acorus calamus linn. leaves extracts
publishDate 2013
url http://eprints.um.edu.my/8130/
_version_ 1643688224631029760
score 13.211869

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