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Solvent Effects On Alkaline Hydrolysis Of N-Benzylphthalimide In Mixed Water-Acetonitrile And Mixed Water-N,N-Dimethylformamide

The nucleophilic second-order rate constant (kappa(OH)) for the reaction of OH- with N-benzylphthalimide appears to follow a reaction mechanism similar to that for reactions of OH with phthalimide and its N-alkylphthalimides. The rate of hydrolysis reveals an insignificant contribution of water-cata...

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Main Authors: Ariffin, Azhar, Khan, M.N., Ye, C.M.
Format: Article
Published: 2005
Subjects:
QD Chemistry
Online Access:http://eprints.um.edu.my/8046/
http://cat.inist.fr/?aModele=afficheN&cpsidt=17165667
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spelling my.um.eprints.80462019-08-27T06:05:29Z http://eprints.um.edu.my/8046/ Solvent Effects On Alkaline Hydrolysis Of N-Benzylphthalimide In Mixed Water-Acetonitrile And Mixed Water-N,N-Dimethylformamide Ariffin, Azhar Khan, M.N. Ye, C.M. QD Chemistry The nucleophilic second-order rate constant (kappa(OH)) for the reaction of OH- with N-benzylphthalimide appears to follow a reaction mechanism similar to that for reactions of OH with phthalimide and its N-alkylphthalimides. The rate of hydrolysis reveals an insignificant contribution of water-catalysed cleavage of NBPT compared with its hydroxide ion catalysed reaction. The observed pseudo first-order rate constant, kappa(obs), for alkaline hydrolysis of NBPT decreases with increase in the content of organic cosolvents (up to 70%, nu/nu) in mixed water-CH3CN and water-DMF solvents. 2005 Article PeerReviewed Ariffin, Azhar and Khan, M.N. and Ye, C.M. (2005) Solvent Effects On Alkaline Hydrolysis Of N-Benzylphthalimide In Mixed Water-Acetonitrile And Mixed Water-N,N-Dimethylformamide. Indian Journal of Chemistry Section a-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry, 44 (10). pp. 2055-2059. ISSN 0376-4710 http://cat.inist.fr/?aModele=afficheN&cpsidt=17165667
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
spellingShingle QD Chemistry
Ariffin, Azhar
Khan, M.N.
Ye, C.M.
Solvent Effects On Alkaline Hydrolysis Of N-Benzylphthalimide In Mixed Water-Acetonitrile And Mixed Water-N,N-Dimethylformamide
description The nucleophilic second-order rate constant (kappa(OH)) for the reaction of OH- with N-benzylphthalimide appears to follow a reaction mechanism similar to that for reactions of OH with phthalimide and its N-alkylphthalimides. The rate of hydrolysis reveals an insignificant contribution of water-catalysed cleavage of NBPT compared with its hydroxide ion catalysed reaction. The observed pseudo first-order rate constant, kappa(obs), for alkaline hydrolysis of NBPT decreases with increase in the content of organic cosolvents (up to 70%, nu/nu) in mixed water-CH3CN and water-DMF solvents.
format Article
author Ariffin, Azhar
Khan, M.N.
Ye, C.M.
author_facet Ariffin, Azhar
Khan, M.N.
Ye, C.M.
author_sort Ariffin, Azhar
title Solvent Effects On Alkaline Hydrolysis Of N-Benzylphthalimide In Mixed Water-Acetonitrile And Mixed Water-N,N-Dimethylformamide
title_short Solvent Effects On Alkaline Hydrolysis Of N-Benzylphthalimide In Mixed Water-Acetonitrile And Mixed Water-N,N-Dimethylformamide
title_full Solvent Effects On Alkaline Hydrolysis Of N-Benzylphthalimide In Mixed Water-Acetonitrile And Mixed Water-N,N-Dimethylformamide
title_fullStr Solvent Effects On Alkaline Hydrolysis Of N-Benzylphthalimide In Mixed Water-Acetonitrile And Mixed Water-N,N-Dimethylformamide
title_full_unstemmed Solvent Effects On Alkaline Hydrolysis Of N-Benzylphthalimide In Mixed Water-Acetonitrile And Mixed Water-N,N-Dimethylformamide
title_sort solvent effects on alkaline hydrolysis of n-benzylphthalimide in mixed water-acetonitrile and mixed water-n,n-dimethylformamide
publishDate 2005
url http://eprints.um.edu.my/8046/
http://cat.inist.fr/?aModele=afficheN&cpsidt=17165667
_version_ 1643688203046092800
score 13.211869

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