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Urinary metabolic evaluation of stone formers-a Malaysian perspective

OBJECTIVE To investigate the urinary metabolic excretion pattern among local stone formers given the great differences in the intrinsic and extrinsic risk factors as well as the urinary metabolic excretions compared with other populations. METHODS Thirty urinary stone formers out of an initial 62 re...

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Main Authors: Hong, Y.H., Dublin, N., Razack, A.H., Mohd, M.A., Husain, R.
Format: Article
Published: 2012
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/7587/
http://www.sciencedirect.com/science/article/pii/S0090429512002725
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spelling my.um.eprints.75872013-08-01T01:54:13Z http://eprints.um.edu.my/7587/ Urinary metabolic evaluation of stone formers-a Malaysian perspective Hong, Y.H. Dublin, N. Razack, A.H. Mohd, M.A. Husain, R. R Medicine OBJECTIVE To investigate the urinary metabolic excretion pattern among local stone formers given the great differences in the intrinsic and extrinsic risk factors as well as the urinary metabolic excretions compared with other populations. METHODS Thirty urinary stone formers out of an initial 62 recruited provided a complete 24-hour urine sample for metabolic evaluation. Student's t-test and Pearson correlation test were used for the statistical analysis. RESULTS Urinary volume (1719 +/- 712 vs 1215 +/- 575, P < .05) and oxalate excretion (0.386 +/- 0.111 vs 0.306 +/- 0.104, P < .05) were significantly higher among stone formers than controls. Other commonly studied urinary parameters and urinary melamine did not differ significantly between the 2 groups. Similarly, the calcium/citrate ratio was unable to discriminate the stone formers from their controls. Hypocitraturia was the most prevalent urinary abnormality found in stone formers and low urinary citrate excretion was a general phenomenon in both stone formers and controls. Comparing within the stone formers cohort, the recurrent stone formers had a significantly higher urinary saturation and calcium excretion than their first-time stone former counterparts. CONCLUSION Elevated urinary oxalate level was the most important urinary risk factor among the local stone formers. A low urinary citrate excretion appeared to be a general phenomenon among the studied cohorts. UROLOGY 80: 529-534, 2012. (c) 2012 Elsevier Inc. 2012 Article PeerReviewed Hong, Y.H. and Dublin, N. and Razack, A.H. and Mohd, M.A. and Husain, R. (2012) Urinary metabolic evaluation of stone formers-a Malaysian perspective. Urology, 80 (3). pp. 529-534. ISSN 0090-4295 http://www.sciencedirect.com/science/article/pii/S0090429512002725 10.1016/j.urology.2012.02.053
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Hong, Y.H.
Dublin, N.
Razack, A.H.
Mohd, M.A.
Husain, R.
Urinary metabolic evaluation of stone formers-a Malaysian perspective
description OBJECTIVE To investigate the urinary metabolic excretion pattern among local stone formers given the great differences in the intrinsic and extrinsic risk factors as well as the urinary metabolic excretions compared with other populations. METHODS Thirty urinary stone formers out of an initial 62 recruited provided a complete 24-hour urine sample for metabolic evaluation. Student's t-test and Pearson correlation test were used for the statistical analysis. RESULTS Urinary volume (1719 +/- 712 vs 1215 +/- 575, P < .05) and oxalate excretion (0.386 +/- 0.111 vs 0.306 +/- 0.104, P < .05) were significantly higher among stone formers than controls. Other commonly studied urinary parameters and urinary melamine did not differ significantly between the 2 groups. Similarly, the calcium/citrate ratio was unable to discriminate the stone formers from their controls. Hypocitraturia was the most prevalent urinary abnormality found in stone formers and low urinary citrate excretion was a general phenomenon in both stone formers and controls. Comparing within the stone formers cohort, the recurrent stone formers had a significantly higher urinary saturation and calcium excretion than their first-time stone former counterparts. CONCLUSION Elevated urinary oxalate level was the most important urinary risk factor among the local stone formers. A low urinary citrate excretion appeared to be a general phenomenon among the studied cohorts. UROLOGY 80: 529-534, 2012. (c) 2012 Elsevier Inc.
format Article
author Hong, Y.H.
Dublin, N.
Razack, A.H.
Mohd, M.A.
Husain, R.
author_facet Hong, Y.H.
Dublin, N.
Razack, A.H.
Mohd, M.A.
Husain, R.
author_sort Hong, Y.H.
title Urinary metabolic evaluation of stone formers-a Malaysian perspective
title_short Urinary metabolic evaluation of stone formers-a Malaysian perspective
title_full Urinary metabolic evaluation of stone formers-a Malaysian perspective
title_fullStr Urinary metabolic evaluation of stone formers-a Malaysian perspective
title_full_unstemmed Urinary metabolic evaluation of stone formers-a Malaysian perspective
title_sort urinary metabolic evaluation of stone formers-a malaysian perspective
publishDate 2012
url http://eprints.um.edu.my/7587/
http://www.sciencedirect.com/science/article/pii/S0090429512002725
_version_ 1643688074705633280
score 13.211869

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