Cover Image

Quantitative LC/MS/MS analysis of acetaminophen–cysteine adducts (APAP–CYS) and its application in acetaminophen overdose patients

A more sensitive approach by liquid chromatography–tandem mass spectrometry (LC/MS/MS) method using the AB Sciex QTRAP 5500 was developed and validated for the detection and quantification of acetaminophen–cysteine adducts (APAP–CYS) in human plasma. Chromatographic separation was achieved using a P...

Full description

Saved in:

Bibliographic Details
Main Authors:	Taha, Hairin, Rahman, Marzilawati Abdul, Haron, Didi Erwandi Mohamad, Mahadeva, Sanjiv, Kee, Lee Yean, Abd Rahman, Noorsaadah, Mohd, Mustafa Ali, Chik, Zamri
Format:	Article
Published:	Royal Society of Chemistry 2013
Subjects:	Q Science (General) QD Chemistry R Medicine
Online Access:	http://eprints.um.edu.my/7274/ https://doi.org/10.1039/C3AY26614A
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Platanosides, a potential botanical drug combination, decrease liver injury caused by acetaminophen overdose in mice
by: Samuvel, Devadoss J., et al.
Published: (2022)

Trace Level Detection of Bisphenol A Analogues and Parabens by LC-MS/MS in Human Plasma from Malaysians
by: Wiraagni, Idha Arfianti, et al.
Published: (2020)

Determination of specific iron chelator by using LC-ICP-MS and LC-ESI-MS
by: Mohamed, Khairul Nizam, et al.
Published: (2015)

Development of LC/MS-MS method for analysis of polyphenols in Malaysian traditional vegetables
by: Haron, Normah, et al.
Published: (2015)

LC-MS/MS simulatneous determination of itopride hydrochloride and domperidone in human plasma
by: Bose, Anirbandeep, et al.
Published: (2009)

Determination of Echimidine and Heliotrine in Tropical Honey by LC-MS/MS / Nurfayyadhah Omar
by: Omar, Nurfayyadhah
Published: (2014)

Development, Optimization and Validation of LC-MS/MS Method for Multi-Mycotoxin Detection in Cereals
by: Soleimany, Farhang
Published: (2011)

LC-PDA-MS/MS-based characterization of key phytochemicals in eurycoma longifolia roots
by: Chua, L. S., et al.
Published: (2021)

Analysis of Pseudomonas sp. polycyclic aromatic hydrocarbons degradation proteins by LC-MS/MS
by: Adenan, Suzana, et al.
Published: (2022)

Efficient amelioration of acetaminophen induced hepatotoxicity by moringa oleifera lam.
by: Fakurazi, Sharida
Published: (2008)

Treatment of acetaminophen and acetylsalicylic acid by chicken bone based adsorbent
by: Yusoff, Nurshuhada Amira
Published: (2019)

Acetaminophen-induced microvascular injury in the rat liver: protection with misoprostol
by: Lim, S.P., et al.
Published: (1996)

Extraction Of Acetaminophen From Aqueous Solution By Emulsion Liquid Membrane
by: Zaulkiflee, Nur Dina
Published: (2019)

Extraction Of Acetaminophen From Aqueous Solution By Emulsion Liquid Membrane
by: Zaulkiflee, Nur Dina
Published: (2019)

LC-MS/MS-based metabolites of Eurycoma longifolia (Tongkat Ali) in Malaysia (Perak and Pahang).
by: Mohd Amin, Nor Amaiza, et al.
Published: (2011)

Development of a method for quantification of two genotoxic impurities in lurasidone using LC-MS/MS
by: Venu, M., et al.
Published: (2019)

Development of a method for quantification of two genotoxic impurities in lurasidone using LC-MS/MS
by: Venu, Manthrapudi, et al.
Published: (2019)

Study of stingless bee (Heterotrigona itama) propolis using LC-MS/MS and TGA-FTIR
by: Lim, Jin Ru, et al.
Published: (2023)

Phytochemical analysis of ethanolic Psidium guajava leaves extract using GC-MS and LC-MS
by: Nursanty, Risa, et al.
Published: (2023)

Development and validation of a LC- MS/MS Method for simultaneous quantitation of telmisartan and pioglitazone in rat plasma
by: Das, Arindam, et al.
Published: (2016)

Characterization of galloylated cyanogenic glucosides and hydrolysabletannins from leaves of Phyllagathis rotundifolia by LC-ESI-MS/MS
by: Chuah, C.H., et al.
Published: (2011)

LC-MS/MS Analysis Of Plasma Homocysteine And Investigation On The Association Of Homocysteine Levels With Diabetic Peripheral Neuropathy
by: Lim, Luen Hui
Published: (2015)

The effect of water quality on removal of acetaminophen in surface water by ozonation process
by: Ahmad Lutpi, Nur Anis, et al.
Published: (2015)

Chemically treated chicken bone waste as an efficient adsorbent for removal of acetaminophen
by: Yusoff, N. A., et al.
Published: (2017)

Identification of chemical compounds from agarwood hydrosol (Aquilaria malaccensis) fruits via LC-QTOF-MS/MS analysis
by: Mohamad Azharishah, Satar, et al.

LC-MS/MS and GC-MS Analysis for the Identification of Bioactive Metabolites Responsible for the Antioxidant and Antibacterial Activities of Lygodium microphyllum (Cav.) R. Br
by: Wuen, Yew Teoh, et al.
Published: (2023)

LC-MS/MS and GC-MS analysis for the identification of bioactive metabolites responsible for the antioxidant and antibacterial activities of Lygodium microphyllum (Cav.) R. Br
by: Teoh, Wuen Yew, et al.
Published: (2023)

Lc-Ms/Ms Profiling and Characterization of Active Components from Medicinal Gingers (Curcuma Xanthorrhiza and Zingiber Zerumbet)
by: Ruslay, Sharin
Published: (2006)

An improved SPE-LC-MS/MS method for multiclass endocrine disrupting compound determination in tropical estuarine sediments
by: Tuan Omar, Tuan Fauzan, et al.
Published: (2017)

The metabolomics approaches based on LC-MS/MS for analysis of non-halal meats in food products: A review
by: Windarsih, Anjar, et al.
Published: (2022)

Assessing the treatment of acetaminophen-contaminated brewery wastewater by an anaerobic packed-bed reactor
by: Abdullah, N., et al.
Published: (2016)

Assessing the treatment of acetaminophen-contaminated brewery wastewater by an anaerobic packed-bed reactor
by: Abdullah, N., et al.
Published: (2016)

Investigation of acetaminophen content in over-the-counter medicine sold in Johor Bahru, Malaysia
by: Zainal, Nurul Syameem
Published: (2019)

Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice
by: Mohammed Alitheen, Noorjahan Banu, et al.
Published: (2018)

α-glucosidase inhibitory and antioxidant activities of different ipomoea aquatica cultivars and lc–ms/ms profiling of the active cultivar
by: Lawal, Umar, et al.
Published: (2016)

α‐Glucosidase inhibitory and antioxidant activities of different ipomoea aquatica cultivars and LC–MS/MS profiling of the active cultivar
by: Lawal, Umar, et al.
Published: (2017)

Prediction of C-glycosylated apigenin (vitexin) biosynthesis in Ficus deltoidea based on plant proteins identified by LC-MS/MS
by: Abdullah, F. I., et al.
Published: (2017)

Effect of Mobile Phase pH on the Electrospray Ionization Efficiency and Qualitative Analysis of Pharmaceuticals in ESI + LC-MS/MS
by: Kafeenah, Husam I.S., et al.
Published: (2019)

Combination of molecular networking and LC-MS/MS profiling in investigating the interrelationships between the antioxidant and antimicrobial properties of Curculigo latifolia
by: Mad Nasir, Nadiah, et al.
Published: (2021)

A comparative study of electrochemical biosensor and LC-MS/MS method for malachite green and leuco-malachite green analysis in fish samples
by: Ahmad Puat, Nurul Hidayah, et al.
Published: (2015)