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Use of glycated hemoglobin (HbA1c) and impaired glucose tolerance in the screening of undiagnosed diabetes in the Malaysian population

Although HbA1c is widely accepted as a useful index of mean blood glucose in type 2 diabetic patients its usefulness as screening test for diabetes has been controversial. The present study was undertaken to determine whether the level of HbA1c predicted diabetes in a prediabetic group of subjects....

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Main Authors: Qvist, R., Ismail, I.S., Chinna, K., Muniandy, S.
Format: Article
Published: 2008
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/7219/
http://link.springer.com/article/10.1007/s12291-008-0055-x
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spelling my.um.eprints.72192014-10-28T05:47:08Z http://eprints.um.edu.my/7219/ Use of glycated hemoglobin (HbA1c) and impaired glucose tolerance in the screening of undiagnosed diabetes in the Malaysian population Qvist, R. Ismail, I.S. Chinna, K. Muniandy, S. R Medicine Although HbA1c is widely accepted as a useful index of mean blood glucose in type 2 diabetic patients its usefulness as screening test for diabetes has been controversial. The present study was undertaken to determine whether the level of HbA1c predicted diabetes in a prediabetic group of subjects. Plasma lipids, oral glucose tolerance, HbA1c was determined in 90 normal control subjects, 57 offspring of one type 2 diabetes mellitus parent and 11 diagnosed type 2 diabetes mellitus individuals. The mean age of participants was 44.5 yrs (not significantly different amongst the three groups) and the mean body mass index was 26.8 (not significantly different amongst the three groups). Two hours after a 75 g glucose challenge, the offspring had a significantly higher plasma glucose level (mean = 7.1 mmol/L, p value = 0.002) than the normals. Similarly the HbA1c values were higher in the offspring than in the normals (mean = 5.78, p value =0.016). Besides the significantly higher values for oral glucose tolerance test and HbA1c , the diabetics also were significantly higher for triglycerides (mean = 2.25mmol/L), total cholesterol (mean = 6.24mmol/L) and systolic blood pressure (mean = 138.45mm Hg) than the offspring (P value = 0.031, 0.006, 0.010) and the normals (P value = 0.026, 0.018, 0.002) respectively. The mean values of diastolic blood pressure, LDL cholesterol and HDL cholesterol were not significantly different amongst the three groups. 2008 Article PeerReviewed Qvist, R. and Ismail, I.S. and Chinna, K. and Muniandy, S. (2008) Use of glycated hemoglobin (HbA1c) and impaired glucose tolerance in the screening of undiagnosed diabetes in the Malaysian population. Indian Journal of Clinical Biochemistry, 23 (3). pp. 246-249. ISSN 0970-1915 http://link.springer.com/article/10.1007/s12291-008-0055-x 10.1007/s12291-008-0055-x
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Qvist, R.
Ismail, I.S.
Chinna, K.
Muniandy, S.
Use of glycated hemoglobin (HbA1c) and impaired glucose tolerance in the screening of undiagnosed diabetes in the Malaysian population
description Although HbA1c is widely accepted as a useful index of mean blood glucose in type 2 diabetic patients its usefulness as screening test for diabetes has been controversial. The present study was undertaken to determine whether the level of HbA1c predicted diabetes in a prediabetic group of subjects. Plasma lipids, oral glucose tolerance, HbA1c was determined in 90 normal control subjects, 57 offspring of one type 2 diabetes mellitus parent and 11 diagnosed type 2 diabetes mellitus individuals. The mean age of participants was 44.5 yrs (not significantly different amongst the three groups) and the mean body mass index was 26.8 (not significantly different amongst the three groups). Two hours after a 75 g glucose challenge, the offspring had a significantly higher plasma glucose level (mean = 7.1 mmol/L, p value = 0.002) than the normals. Similarly the HbA1c values were higher in the offspring than in the normals (mean = 5.78, p value =0.016). Besides the significantly higher values for oral glucose tolerance test and HbA1c , the diabetics also were significantly higher for triglycerides (mean = 2.25mmol/L), total cholesterol (mean = 6.24mmol/L) and systolic blood pressure (mean = 138.45mm Hg) than the offspring (P value = 0.031, 0.006, 0.010) and the normals (P value = 0.026, 0.018, 0.002) respectively. The mean values of diastolic blood pressure, LDL cholesterol and HDL cholesterol were not significantly different amongst the three groups.
format Article
author Qvist, R.
Ismail, I.S.
Chinna, K.
Muniandy, S.
author_facet Qvist, R.
Ismail, I.S.
Chinna, K.
Muniandy, S.
author_sort Qvist, R.
title Use of glycated hemoglobin (HbA1c) and impaired glucose tolerance in the screening of undiagnosed diabetes in the Malaysian population
title_short Use of glycated hemoglobin (HbA1c) and impaired glucose tolerance in the screening of undiagnosed diabetes in the Malaysian population
title_full Use of glycated hemoglobin (HbA1c) and impaired glucose tolerance in the screening of undiagnosed diabetes in the Malaysian population
title_fullStr Use of glycated hemoglobin (HbA1c) and impaired glucose tolerance in the screening of undiagnosed diabetes in the Malaysian population
title_full_unstemmed Use of glycated hemoglobin (HbA1c) and impaired glucose tolerance in the screening of undiagnosed diabetes in the Malaysian population
title_sort use of glycated hemoglobin (hba1c) and impaired glucose tolerance in the screening of undiagnosed diabetes in the malaysian population
publishDate 2008
url http://eprints.um.edu.my/7219/
http://link.springer.com/article/10.1007/s12291-008-0055-x
_version_ 1643687992673435648
score 13.211869

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