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IGF2BP2 alternative variants associated with glutamic acid decarboxylase antibodies negative diabetes in Malaysian subjects

Background: The association of Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) common variants (rs4402960 and rs1470579) with type 2 diabetes (T2D) has been performed in different populations. The aim of this study was to evaluate the association of alternative variants of IGF2BP2; rs6...

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Main Authors: Salem, S.D., Saif-Ali, R., Ismail, I.S., Al-Hamodi, Z., Poh, R., Muniandy, S.
Format: Article
Language:English
Published: Public Library of Science 2012
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/7206/1/Salem-2012-IGF2BP2_Alternative.pdf
http://eprints.um.edu.my/7206/
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spelling my.um.eprints.72062017-07-05T01:31:21Z http://eprints.um.edu.my/7206/ IGF2BP2 alternative variants associated with glutamic acid decarboxylase antibodies negative diabetes in Malaysian subjects Salem, S.D. Saif-Ali, R. Ismail, I.S. Al-Hamodi, Z. Poh, R. Muniandy, S. R Medicine Background: The association of Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) common variants (rs4402960 and rs1470579) with type 2 diabetes (T2D) has been performed in different populations. The aim of this study was to evaluate the association of alternative variants of IGF2BP2; rs6777038, rs16860234 and rs7651090 with glutamic acid decarboxylase antibodies (GADA) negative diabetes in Malaysian Subjects. Methods/Principal Findings: IGF2BP2; rs6777038, rs16860234 and rs7651090 single nucleotide polymorphisms (SNPs) were genotyped in 1107 GADA negative diabetic patients and 620 control subjects of Asian from Malaysia. The additive genetic model adjusted for age, race, gender and BMI showed that alternative variants; rs6777038, rs16860234 and rs7651090 of IGF2BP2 associated with GADA negative diabetes (OR = 1.21; 1.36; 1.35, P = 0.03; 0.0004; 0.0002, respectively). In addition, the CCG haplotype and diplotype CCG-TCG increased the risk of diabetes (OR = 1.51, P = 0.01; OR = 2.36, P = 0.009, respectively). Conclusions/Significance: IGF2BP2 alternative variants were associated with GADA negative diabetes. The IGF2BP2 haplotypes and diplotypes increased the risk of diabetes in Malaysian subject. Public Library of Science 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/7206/1/Salem-2012-IGF2BP2_Alternative.pdf Salem, S.D. and Saif-Ali, R. and Ismail, I.S. and Al-Hamodi, Z. and Poh, R. and Muniandy, S. (2012) IGF2BP2 alternative variants associated with glutamic acid decarboxylase antibodies negative diabetes in Malaysian subjects. PLoS ONE, 7 (9). ISSN 1932-6203 10.1371/journal.pone.0045573
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine
spellingShingle R Medicine
Salem, S.D.
Saif-Ali, R.
Ismail, I.S.
Al-Hamodi, Z.
Poh, R.
Muniandy, S.
IGF2BP2 alternative variants associated with glutamic acid decarboxylase antibodies negative diabetes in Malaysian subjects
description Background: The association of Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) common variants (rs4402960 and rs1470579) with type 2 diabetes (T2D) has been performed in different populations. The aim of this study was to evaluate the association of alternative variants of IGF2BP2; rs6777038, rs16860234 and rs7651090 with glutamic acid decarboxylase antibodies (GADA) negative diabetes in Malaysian Subjects. Methods/Principal Findings: IGF2BP2; rs6777038, rs16860234 and rs7651090 single nucleotide polymorphisms (SNPs) were genotyped in 1107 GADA negative diabetic patients and 620 control subjects of Asian from Malaysia. The additive genetic model adjusted for age, race, gender and BMI showed that alternative variants; rs6777038, rs16860234 and rs7651090 of IGF2BP2 associated with GADA negative diabetes (OR = 1.21; 1.36; 1.35, P = 0.03; 0.0004; 0.0002, respectively). In addition, the CCG haplotype and diplotype CCG-TCG increased the risk of diabetes (OR = 1.51, P = 0.01; OR = 2.36, P = 0.009, respectively). Conclusions/Significance: IGF2BP2 alternative variants were associated with GADA negative diabetes. The IGF2BP2 haplotypes and diplotypes increased the risk of diabetes in Malaysian subject.
format Article
author Salem, S.D.
Saif-Ali, R.
Ismail, I.S.
Al-Hamodi, Z.
Poh, R.
Muniandy, S.
author_facet Salem, S.D.
Saif-Ali, R.
Ismail, I.S.
Al-Hamodi, Z.
Poh, R.
Muniandy, S.
author_sort Salem, S.D.
title IGF2BP2 alternative variants associated with glutamic acid decarboxylase antibodies negative diabetes in Malaysian subjects
title_short IGF2BP2 alternative variants associated with glutamic acid decarboxylase antibodies negative diabetes in Malaysian subjects
title_full IGF2BP2 alternative variants associated with glutamic acid decarboxylase antibodies negative diabetes in Malaysian subjects
title_fullStr IGF2BP2 alternative variants associated with glutamic acid decarboxylase antibodies negative diabetes in Malaysian subjects
title_full_unstemmed IGF2BP2 alternative variants associated with glutamic acid decarboxylase antibodies negative diabetes in Malaysian subjects
title_sort igf2bp2 alternative variants associated with glutamic acid decarboxylase antibodies negative diabetes in malaysian subjects
publisher Public Library of Science
publishDate 2012
url http://eprints.um.edu.my/7206/1/Salem-2012-IGF2BP2_Alternative.pdf
http://eprints.um.edu.my/7206/
_version_ 1643687989461647360
score 13.211869

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