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A search for dengue 2 virus inhibitor from tripeptides and hexapeptides

Libraries of tripeptides and hexapeptides were screened for inhibitory activity against the dengue protease complex. Libraries of tripeptide showed very weak inhibition towards dengue protease, On the other hand, libraries of hexapeptide, designed based on substrate-based inhibitors, where basic ami...

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Main Authors: Abd Rahman, Noorsaadah, Kt, Teoh, Yusof, Rohana
Format: Article
Published: Faculty of Science, University of Malaya 2005
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/7142/
https://ejournal.um.edu.my/index.php/MJS/article/view/8298
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spelling my.um.eprints.71422018-10-10T06:53:41Z http://eprints.um.edu.my/7142/ A search for dengue 2 virus inhibitor from tripeptides and hexapeptides Abd Rahman, Noorsaadah Kt, Teoh Yusof, Rohana R Medicine Libraries of tripeptides and hexapeptides were screened for inhibitory activity against the dengue protease complex. Libraries of tripeptide showed very weak inhibition towards dengue protease, On the other hand, libraries of hexapeptide, designed based on substrate-based inhibitors, where basic amino acids, such as arginine or lysine at the P1 position incorporated with non-coded amino acids, showed an increase in potency. The library H2L1 was the most promising candidate with 33.0 inhibition (8.0 mg/ml), but library H2L2 (2.0mg/ml) possesses considerably weak inhibition. On theother hand, library H2L3 showed 21.3 inhibition against the protease activity. Overall, libraries of hexapeptide were considered weak in inhibitory effect although they showed better inhibitory activities than the tripeptide libraries. Although the inhibitory activities of these peptide libraries are in the mg/mL range, the combinatorial library synthesized has provided indispensable information towards the design of possible inhibitors. Faculty of Science, University of Malaya 2005 Article PeerReviewed Abd Rahman, Noorsaadah and Kt, Teoh and Yusof, Rohana (2005) A search for dengue 2 virus inhibitor from tripeptides and hexapeptides. Malaysian Journal of Science, 24 (2). pp. 13-20. ISSN 1394-3065 https://ejournal.um.edu.my/index.php/MJS/article/view/8298
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Abd Rahman, Noorsaadah
Kt, Teoh
Yusof, Rohana
A search for dengue 2 virus inhibitor from tripeptides and hexapeptides
description Libraries of tripeptides and hexapeptides were screened for inhibitory activity against the dengue protease complex. Libraries of tripeptide showed very weak inhibition towards dengue protease, On the other hand, libraries of hexapeptide, designed based on substrate-based inhibitors, where basic amino acids, such as arginine or lysine at the P1 position incorporated with non-coded amino acids, showed an increase in potency. The library H2L1 was the most promising candidate with 33.0 inhibition (8.0 mg/ml), but library H2L2 (2.0mg/ml) possesses considerably weak inhibition. On theother hand, library H2L3 showed 21.3 inhibition against the protease activity. Overall, libraries of hexapeptide were considered weak in inhibitory effect although they showed better inhibitory activities than the tripeptide libraries. Although the inhibitory activities of these peptide libraries are in the mg/mL range, the combinatorial library synthesized has provided indispensable information towards the design of possible inhibitors.
format Article
author Abd Rahman, Noorsaadah
Kt, Teoh
Yusof, Rohana
author_facet Abd Rahman, Noorsaadah
Kt, Teoh
Yusof, Rohana
author_sort Abd Rahman, Noorsaadah
title A search for dengue 2 virus inhibitor from tripeptides and hexapeptides
title_short A search for dengue 2 virus inhibitor from tripeptides and hexapeptides
title_full A search for dengue 2 virus inhibitor from tripeptides and hexapeptides
title_fullStr A search for dengue 2 virus inhibitor from tripeptides and hexapeptides
title_full_unstemmed A search for dengue 2 virus inhibitor from tripeptides and hexapeptides
title_sort search for dengue 2 virus inhibitor from tripeptides and hexapeptides
publisher Faculty of Science, University of Malaya
publishDate 2005
url http://eprints.um.edu.my/7142/
https://ejournal.um.edu.my/index.php/MJS/article/view/8298
_version_ 1643687977231056896
score 13.211869

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