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Ameloblastoma of the jaws: a retrospective analysis of 340 cases in a Malaysian population

Purpose: Ameloblastoma of the human jaw is an uncommon but clinically significant odontogenic epithelial neoplasm. The aim was to analyze the clinicopathologic characteristics of ameloblastoma in a Malaysian population. Materials and Methods: This is a retrospective study (1993 through 2008) of...

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Main Authors: Siar, Chong Huat, Lau, Shin Hin, Ng, Kok Han
Format: Article
Language:English
Published: Elsevier 2012
Subjects:
RK Dentistry
Oral surger
Online Access:http://eprints.um.edu.my/5736/1/amelob_msia_siar__12.pdf
http://eprints.um.edu.my/5736/
https://doi.org/10.1016/j.joms.2011.02.039
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spelling my.um.eprints.57362019-11-22T06:23:29Z http://eprints.um.edu.my/5736/ Ameloblastoma of the jaws: a retrospective analysis of 340 cases in a Malaysian population Siar, Chong Huat Lau, Shin Hin Ng, Kok Han RK Dentistry Oral surger Purpose: Ameloblastoma of the human jaw is an uncommon but clinically significant odontogenic epithelial neoplasm. The aim was to analyze the clinicopathologic characteristics of ameloblastoma in a Malaysian population. Materials and Methods: This is a retrospective study (1993 through 2008) of consecutive ameloblastoma cases accessioned in 2 main oral pathology diagnostic centers: the Unit of Stomatology, Institute for Medical Research and the Department of Oral Pathology, Oral Medicine, and Periodontology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia. Data on patient demographics, tumor location, symptomology, duration, radiographic appearance, preoperative diagnosis, clinicopathologic subtypes, treatment, and recurrence were analyzed. Results: Three hundred forty cases of ameloblastoma were reviewed. These were from 197 male patients (57.9%) and 143 female patients (42.1%), with a male-to-female ratio of 1.4:1. A wide age range (7 to 85 years), mean onset age of 30.3 ± 16.3 years, and peak incidence in the second decade of life were recorded. Most were mandibular tumors (n = 311/340, 91.5%). These consisted of 95 (28%) unicystic ameloblastomas, 221 (65%) solid/multicystic ameloblastomas, 22 (6.4%) desmoplastic ameloblastoma, and 2 (0.6%) peripheral ameloblastomas. Unicystic ameloblastoma (41.1%) and solid/multicystic ameloblastoma (52.0%) mostly affected Malays patients, whereas desmoplastic ameloblastoma (59.1%) was prevalent in Chinese patients. Unicystic ameloblastoma (56.8%) and solid/multicystic ameloblastoma (47.1%) occurred predominantly in the body and posterior mandible, whereas desmoplastic ameloblastoma (36.4%) preferentially involved the anterior jaw segment. Most tumors presented as multilocular radiolucencies (36.8%). Enucleation (n = 42/92, 45.7%) was the treatment of choice. About 18 cases (13.3%) presented with recurrence. Conclusions: Because ameloblastoma subsets differ in their biologic behavior, the present data are significant as baseline references for clinicians and pathologists. Elsevier 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/5736/1/amelob_msia_siar__12.pdf Siar, Chong Huat and Lau, Shin Hin and Ng, Kok Han (2012) Ameloblastoma of the jaws: a retrospective analysis of 340 cases in a Malaysian population. Journal of Oral and Maxillofacial Surgery, 70 (3). pp. 608-615. ISSN 0278-2391 https://doi.org/10.1016/j.joms.2011.02.039 doi:10.1016/j.joms.2011.02.039
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic RK Dentistry
Oral surger
spellingShingle RK Dentistry
Oral surger
Siar, Chong Huat
Lau, Shin Hin
Ng, Kok Han
Ameloblastoma of the jaws: a retrospective analysis of 340 cases in a Malaysian population
description Purpose: Ameloblastoma of the human jaw is an uncommon but clinically significant odontogenic epithelial neoplasm. The aim was to analyze the clinicopathologic characteristics of ameloblastoma in a Malaysian population. Materials and Methods: This is a retrospective study (1993 through 2008) of consecutive ameloblastoma cases accessioned in 2 main oral pathology diagnostic centers: the Unit of Stomatology, Institute for Medical Research and the Department of Oral Pathology, Oral Medicine, and Periodontology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia. Data on patient demographics, tumor location, symptomology, duration, radiographic appearance, preoperative diagnosis, clinicopathologic subtypes, treatment, and recurrence were analyzed. Results: Three hundred forty cases of ameloblastoma were reviewed. These were from 197 male patients (57.9%) and 143 female patients (42.1%), with a male-to-female ratio of 1.4:1. A wide age range (7 to 85 years), mean onset age of 30.3 ± 16.3 years, and peak incidence in the second decade of life were recorded. Most were mandibular tumors (n = 311/340, 91.5%). These consisted of 95 (28%) unicystic ameloblastomas, 221 (65%) solid/multicystic ameloblastomas, 22 (6.4%) desmoplastic ameloblastoma, and 2 (0.6%) peripheral ameloblastomas. Unicystic ameloblastoma (41.1%) and solid/multicystic ameloblastoma (52.0%) mostly affected Malays patients, whereas desmoplastic ameloblastoma (59.1%) was prevalent in Chinese patients. Unicystic ameloblastoma (56.8%) and solid/multicystic ameloblastoma (47.1%) occurred predominantly in the body and posterior mandible, whereas desmoplastic ameloblastoma (36.4%) preferentially involved the anterior jaw segment. Most tumors presented as multilocular radiolucencies (36.8%). Enucleation (n = 42/92, 45.7%) was the treatment of choice. About 18 cases (13.3%) presented with recurrence. Conclusions: Because ameloblastoma subsets differ in their biologic behavior, the present data are significant as baseline references for clinicians and pathologists.
format Article
author Siar, Chong Huat
Lau, Shin Hin
Ng, Kok Han
author_facet Siar, Chong Huat
Lau, Shin Hin
Ng, Kok Han
author_sort Siar, Chong Huat
title Ameloblastoma of the jaws: a retrospective analysis of 340 cases in a Malaysian population
title_short Ameloblastoma of the jaws: a retrospective analysis of 340 cases in a Malaysian population
title_full Ameloblastoma of the jaws: a retrospective analysis of 340 cases in a Malaysian population
title_fullStr Ameloblastoma of the jaws: a retrospective analysis of 340 cases in a Malaysian population
title_full_unstemmed Ameloblastoma of the jaws: a retrospective analysis of 340 cases in a Malaysian population
title_sort ameloblastoma of the jaws: a retrospective analysis of 340 cases in a malaysian population
publisher Elsevier
publishDate 2012
url http://eprints.um.edu.my/5736/1/amelob_msia_siar__12.pdf
http://eprints.um.edu.my/5736/
https://doi.org/10.1016/j.joms.2011.02.039
_version_ 1651867325964484608
score 13.211869

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