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Synthesis and biological activities of nickel(II) and cadmium(II) complexes of chlorohydroxyacetophenone-nitrobenzoylhydrazone: mechanism for formation of the nickel(II) complex

The new Nickel(II) and Cadmium(II) complexes have been prepared in ethanol by template condensation of 4-nitrobenzhydrazide, 5-chloro-2-hydroxyacetophenone and metal acetate in the presence of triethylamine. The IR and UV spectra of the ligand and complexes indicate coordination of ligands to the me...

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Main Authors:	Ali, Hapipah Mohd, Ismail, E., Zain, S.M., Subramaniam, P., Abdul Halim, S.N.
Format:	Article
Published:	Faculty of Science, University of Malaya 2006
Subjects:	QD Chemistry
Online Access:	http://eprints.um.edu.my/5539/ http://www.scopus.com/inward/record.url?eid=2-s2.0-34247468898&partnerID=40&md5=75d073f5f4f63cdc7f06f125d1312b8f
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spelling	my.um.eprints.55392021-04-28T07:01:39Z http://eprints.um.edu.my/5539/ Synthesis and biological activities of nickel(II) and cadmium(II) complexes of chlorohydroxyacetophenone-nitrobenzoylhydrazone: mechanism for formation of the nickel(II) complex Ali, Hapipah Mohd Ismail, E. Zain, S.M. Subramaniam, P. Abdul Halim, S.N. QD Chemistry The new Nickel(II) and Cadmium(II) complexes have been prepared in ethanol by template condensation of 4-nitrobenzhydrazide, 5-chloro-2-hydroxyacetophenone and metal acetate in the presence of triethylamine. The IR and UV spectra of the ligand and complexes indicate coordination of ligands to the metal centers. The initial product of the Nickel(II) complex is a square planar compound and upon recrydallization with pyridine, the complex has changed to octahedral geometry with coordination of the solvent molecules. The Schiff base ligand, H 25-Clhap-4-NO 2bh was more sensitive towards the MCF-7 cells (human breast cancer cells) with IC 50 values of 4.5 μg ml -1 than the unsubstituted ligand, H 2hapbh. However upon coordination to nickel, the activity has been reduced to the same level as the positive control drug, tamoxifen. The antioxidant properties of the Schiff base ligand (using the FTC method) exhibited higher activity than vitamin E or quercetine. However the activity is lower than the unsubstituted Schiff base ligand or the commercial antioxidant agent, BHT (butylated hydroxytoluene). Faculty of Science, University of Malaya 2006 Article PeerReviewed Ali, Hapipah Mohd and Ismail, E. and Zain, S.M. and Subramaniam, P. and Abdul Halim, S.N. (2006) Synthesis and biological activities of nickel(II) and cadmium(II) complexes of chlorohydroxyacetophenone-nitrobenzoylhydrazone: mechanism for formation of the nickel(II) complex. Malaysian Journal of Science, 25 (1). pp. 99-105. ISSN 1394-3065 http://www.scopus.com/inward/record.url?eid=2-s2.0-34247468898&partnerID=40&md5=75d073f5f4f63cdc7f06f125d1312b8f
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	QD Chemistry
spellingShingle	QD Chemistry Ali, Hapipah Mohd Ismail, E. Zain, S.M. Subramaniam, P. Abdul Halim, S.N. Synthesis and biological activities of nickel(II) and cadmium(II) complexes of chlorohydroxyacetophenone-nitrobenzoylhydrazone: mechanism for formation of the nickel(II) complex
description	The new Nickel(II) and Cadmium(II) complexes have been prepared in ethanol by template condensation of 4-nitrobenzhydrazide, 5-chloro-2-hydroxyacetophenone and metal acetate in the presence of triethylamine. The IR and UV spectra of the ligand and complexes indicate coordination of ligands to the metal centers. The initial product of the Nickel(II) complex is a square planar compound and upon recrydallization with pyridine, the complex has changed to octahedral geometry with coordination of the solvent molecules. The Schiff base ligand, H 25-Clhap-4-NO 2bh was more sensitive towards the MCF-7 cells (human breast cancer cells) with IC 50 values of 4.5 μg ml -1 than the unsubstituted ligand, H 2hapbh. However upon coordination to nickel, the activity has been reduced to the same level as the positive control drug, tamoxifen. The antioxidant properties of the Schiff base ligand (using the FTC method) exhibited higher activity than vitamin E or quercetine. However the activity is lower than the unsubstituted Schiff base ligand or the commercial antioxidant agent, BHT (butylated hydroxytoluene).
format	Article
author	Ali, Hapipah Mohd Ismail, E. Zain, S.M. Subramaniam, P. Abdul Halim, S.N.
author_facet	Ali, Hapipah Mohd Ismail, E. Zain, S.M. Subramaniam, P. Abdul Halim, S.N.
author_sort	Ali, Hapipah Mohd
title	Synthesis and biological activities of nickel(II) and cadmium(II) complexes of chlorohydroxyacetophenone-nitrobenzoylhydrazone: mechanism for formation of the nickel(II) complex
title_short	Synthesis and biological activities of nickel(II) and cadmium(II) complexes of chlorohydroxyacetophenone-nitrobenzoylhydrazone: mechanism for formation of the nickel(II) complex
title_full	Synthesis and biological activities of nickel(II) and cadmium(II) complexes of chlorohydroxyacetophenone-nitrobenzoylhydrazone: mechanism for formation of the nickel(II) complex
title_fullStr	Synthesis and biological activities of nickel(II) and cadmium(II) complexes of chlorohydroxyacetophenone-nitrobenzoylhydrazone: mechanism for formation of the nickel(II) complex
title_full_unstemmed	Synthesis and biological activities of nickel(II) and cadmium(II) complexes of chlorohydroxyacetophenone-nitrobenzoylhydrazone: mechanism for formation of the nickel(II) complex
title_sort	synthesis and biological activities of nickel(ii) and cadmium(ii) complexes of chlorohydroxyacetophenone-nitrobenzoylhydrazone: mechanism for formation of the nickel(ii) complex
publisher	Faculty of Science, University of Malaya
publishDate	2006
url	http://eprints.um.edu.my/5539/ http://www.scopus.com/inward/record.url?eid=2-s2.0-34247468898&partnerID=40&md5=75d073f5f4f63cdc7f06f125d1312b8f
_version_	1698697301478866944
score	13.211869

Synthesis and biological activities of nickel(II) and cadmium(II) complexes of chlorohydroxyacetophenone-nitrobenzoylhydrazone: mechanism for formation of the nickel(II) complex

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