Antioxidant, cytotoxic activities, and structure-activity relationship of gallic acid-based indole derivatives
A new series of gallic hydrazones containing an indole moiety was synthesized through the reaction of gallic hydrazide and different indole carboxaldehydes. Their antioxidant activities were determined on DPPH radical scavenging and inhibition of lipid peroxidation. The in-vitro cytotoxic activities...
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Wiley-VCH Verlag
2011
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my.um.eprints.52242019-01-30T01:09:58Z http://eprints.um.edu.my/5224/ Antioxidant, cytotoxic activities, and structure-activity relationship of gallic acid-based indole derivatives Khaledi, H. Alhadi, A.A. Yehye, W.A. Ali, Hapipah Mohd Abdulla, Mahmood Ameen Hassandarvish, P. QD Chemistry A new series of gallic hydrazones containing an indole moiety was synthesized through the reaction of gallic hydrazide and different indole carboxaldehydes. Their antioxidant activities were determined on DPPH radical scavenging and inhibition of lipid peroxidation. The in-vitro cytotoxic activities of the compounds were evaluated against HCT-116 (human colon cancer cell line) and MCF-7 (estrogen-dependent human breast cancer cell line) by the MTT method. An attempt to correlate the biological results with their structural characteristics has been done. A limited positive structure activity relationship was found between cytotoxic and antioxidant activities. Wiley-VCH Verlag 2011-11 Article PeerReviewed Khaledi, H. and Alhadi, A.A. and Yehye, W.A. and Ali, Hapipah Mohd and Abdulla, Mahmood Ameen and Hassandarvish, P. (2011) Antioxidant, cytotoxic activities, and structure-activity relationship of gallic acid-based indole derivatives. Archiv der Pharmazie / Chemistry in Life Sciences, 344 (11). pp. 703-709. ISSN 0365-6233 http://onlinelibrary.wiley.com/doi/10.1002/ardp.201000223/abstract http://dx.doi.org/10.1002/ardp.201000223 |
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QD Chemistry Khaledi, H. Alhadi, A.A. Yehye, W.A. Ali, Hapipah Mohd Abdulla, Mahmood Ameen Hassandarvish, P. Antioxidant, cytotoxic activities, and structure-activity relationship of gallic acid-based indole derivatives |
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A new series of gallic hydrazones containing an indole moiety was synthesized through the reaction of gallic hydrazide and different indole carboxaldehydes. Their antioxidant activities were determined on DPPH radical scavenging and inhibition of lipid peroxidation. The in-vitro cytotoxic activities of the compounds were evaluated against HCT-116 (human colon cancer cell line) and MCF-7 (estrogen-dependent human breast cancer cell line) by the MTT method. An attempt to correlate the biological results with their structural characteristics has been done. A limited positive structure activity relationship was found between cytotoxic and antioxidant activities. |
| format |
Article |
| author |
Khaledi, H. Alhadi, A.A. Yehye, W.A. Ali, Hapipah Mohd Abdulla, Mahmood Ameen Hassandarvish, P. |
| author_facet |
Khaledi, H. Alhadi, A.A. Yehye, W.A. Ali, Hapipah Mohd Abdulla, Mahmood Ameen Hassandarvish, P. |
| author_sort |
Khaledi, H. |
| title |
Antioxidant, cytotoxic activities, and structure-activity relationship of gallic acid-based indole derivatives |
| title_short |
Antioxidant, cytotoxic activities, and structure-activity relationship of gallic acid-based indole derivatives |
| title_full |
Antioxidant, cytotoxic activities, and structure-activity relationship of gallic acid-based indole derivatives |
| title_fullStr |
Antioxidant, cytotoxic activities, and structure-activity relationship of gallic acid-based indole derivatives |
| title_full_unstemmed |
Antioxidant, cytotoxic activities, and structure-activity relationship of gallic acid-based indole derivatives |
| title_sort |
antioxidant, cytotoxic activities, and structure-activity relationship of gallic acid-based indole derivatives |
| publisher |
Wiley-VCH Verlag |
| publishDate |
2011 |
| url |
http://eprints.um.edu.my/5224/ http://onlinelibrary.wiley.com/doi/10.1002/ardp.201000223/abstract http://dx.doi.org/10.1002/ardp.201000223 |
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