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Assessment of in vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of phyllanthus niruri

Background: Recently much attention has been paid to biologically active plants because of their low production cost and fewer adverse effects compared with chemical drugs. In the present investigation the bioactivity of Phyllanthus niruri ethanol and aqueous extracts was evaluated in vitro. Results...

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Main Authors: Amin, Z.A., Qadir, S.W., Alshawsh, M.A., Ali, Hapipah Mohd, Abdulla, M.A.
Format: Article
Published: Wiley 2012
Subjects:
QD Chemistry
Online Access:http://eprints.um.edu.my/5149/
http://www.scopus.com/inward/record.url?eid=2-s2.0-84861994353&partnerID=40&md5=ba98007a7a64623ffe6da7c24d0c76ea
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spelling my.um.eprints.51492019-03-21T06:33:14Z http://eprints.um.edu.my/5149/ Assessment of in vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of phyllanthus niruri Amin, Z.A. Qadir, S.W. Alshawsh, M.A. Ali, Hapipah Mohd Abdulla, M.A. QD Chemistry Background: Recently much attention has been paid to biologically active plants because of their low production cost and fewer adverse effects compared with chemical drugs. In the present investigation the bioactivity of Phyllanthus niruri ethanol and aqueous extracts was evaluated in vitro. Results: The ethanol extract of P. niruri showed a high level of flavonoid content (123.9 ± 0.002 mg g -1), while the aqueous extract showed the highest 2,2-diphenyl-1-picrylhydrazyl (DPPH; IC 506.85 ± 1.80 μmol L -1) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS; 46.44 ± 0.53 μmol L -1) free radical scavenging activities with high phenol content (376 ± 0.02 mg g -1) and elevated levels of ferric reducing antioxidant power (FRAP; 23 883 ± 0.019 mmol g -1) with excellent antibacterial activity against Staphylococcus aureus (20 mm inhibition zone) and Streptococcus agalactiae (12 mm inhibition zone), respectively, in addition to the best immune activation potential of human peripheral blood mononuclear cells (450.5%). Conclusions: It is clear from our results that both extracts of P. niruri has excellent bioactivity roles via elevated levels of antibacterial, antioxidant and percentage of peripheral blood mononuclear cell proliferation, which could lead to the development of medications for clinical use. © 2012 Society of Chemical Industry. Wiley 2012 Article PeerReviewed Amin, Z.A. and Qadir, S.W. and Alshawsh, M.A. and Ali, Hapipah Mohd and Abdulla, M.A. (2012) Assessment of in vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of phyllanthus niruri. Journal of the Science of Food and Agriculture, 92 (9). pp. 1874-1877. ISSN 0022-5142 http://www.scopus.com/inward/record.url?eid=2-s2.0-84861994353&partnerID=40&md5=ba98007a7a64623ffe6da7c24d0c76ea 10.1002/jsfa.5554
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
spellingShingle QD Chemistry
Amin, Z.A.
Qadir, S.W.
Alshawsh, M.A.
Ali, Hapipah Mohd
Abdulla, M.A.
Assessment of in vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of phyllanthus niruri
description Background: Recently much attention has been paid to biologically active plants because of their low production cost and fewer adverse effects compared with chemical drugs. In the present investigation the bioactivity of Phyllanthus niruri ethanol and aqueous extracts was evaluated in vitro. Results: The ethanol extract of P. niruri showed a high level of flavonoid content (123.9 ± 0.002 mg g -1), while the aqueous extract showed the highest 2,2-diphenyl-1-picrylhydrazyl (DPPH; IC 506.85 ± 1.80 μmol L -1) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS; 46.44 ± 0.53 μmol L -1) free radical scavenging activities with high phenol content (376 ± 0.02 mg g -1) and elevated levels of ferric reducing antioxidant power (FRAP; 23 883 ± 0.019 mmol g -1) with excellent antibacterial activity against Staphylococcus aureus (20 mm inhibition zone) and Streptococcus agalactiae (12 mm inhibition zone), respectively, in addition to the best immune activation potential of human peripheral blood mononuclear cells (450.5%). Conclusions: It is clear from our results that both extracts of P. niruri has excellent bioactivity roles via elevated levels of antibacterial, antioxidant and percentage of peripheral blood mononuclear cell proliferation, which could lead to the development of medications for clinical use. © 2012 Society of Chemical Industry.
format Article
author Amin, Z.A.
Qadir, S.W.
Alshawsh, M.A.
Ali, Hapipah Mohd
Abdulla, M.A.
author_facet Amin, Z.A.
Qadir, S.W.
Alshawsh, M.A.
Ali, Hapipah Mohd
Abdulla, M.A.
author_sort Amin, Z.A.
title Assessment of in vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of phyllanthus niruri
title_short Assessment of in vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of phyllanthus niruri
title_full Assessment of in vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of phyllanthus niruri
title_fullStr Assessment of in vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of phyllanthus niruri
title_full_unstemmed Assessment of in vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of phyllanthus niruri
title_sort assessment of in vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of phyllanthus niruri
publisher Wiley
publishDate 2012
url http://eprints.um.edu.my/5149/
http://www.scopus.com/inward/record.url?eid=2-s2.0-84861994353&partnerID=40&md5=ba98007a7a64623ffe6da7c24d0c76ea
_version_ 1643687498064330752
score 13.211869

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