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Comparative pharmacokinetics of theophylline in camels (Camelus dromedarius) and goats (Caprus hircus)

A comparative randomized crossover study was conducted to determine the pharmacokinetics of theophylline in male and female camels (Camelus dromedarius) and goats (Caprus hircus). Theophylline is an established 'probe drug' to evaluate the drug metabolizing enzyme activity of animals. It w...

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Main Authors: Elsheikh, H.A., Ali, B.H., Zahurin, M., Mustafa, A.M., Alhadrami, G., Bashir, A.K.
Format: Article
Published: 2001
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/5105/
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spelling my.um.eprints.51052013-04-18T00:27:04Z http://eprints.um.edu.my/5105/ Comparative pharmacokinetics of theophylline in camels (Camelus dromedarius) and goats (Caprus hircus) Elsheikh, H.A. Ali, B.H. Zahurin, M. Mustafa, A.M. Alhadrami, G. Bashir, A.K. R Medicine A comparative randomized crossover study was conducted to determine the pharmacokinetics of theophylline in male and female camels (Camelus dromedarius) and goats (Caprus hircus). Theophylline is an established 'probe drug' to evaluate the drug metabolizing enzyme activity of animals. It was administered by the intravenous (i.v.) route and then intramuscularly (i.m.) at a dose of 2 mg/kg. The concentration of the drug in plasma was measured using a high-performance liquid chromatography (HPLC) technique on samples collected at frequent intervals after administration. Following i.v. injection, die overall elimination rate constant (lambda(z)) in goats was 0.006 +/- 0.00076/min and in camels was 0.0046 +/- 0.0008/min (P < 0.01). The elimination half-life (t(1/2lambdaz)) in goats (112.7 min) was lower than in camels (154.7 min) (P < 0.01). The apparent volume of distribution (V-z) and the total body clearance (Cl) in goats were 1440.1 +/- 166.6 ml/kg and 8.9 +/- 1.4 ml/min/ kg, respectively. The corresponding values in camels were 1720.3 +/- 345.3 ml/kg and 6.1 +/- 1.0 ml/ min/kg, respectively. After i.m. administration, theophylline reached a peak plasma concentration (C-max) of 1.8 +/- 0.1 and 1.7 +/- 0.2 mug/ml at a post-injection dine (T-max) of 67.5 +/- 8.6 and 122.3 +/- 6.7 min in goats and camels, respectively. The mean bioavailability (F) in both goats and camels was 0.9 +/- 0.2. The above data suggest that camels eliminate theophylline at a slower rate than goats. 2001 Article PeerReviewed Elsheikh, H.A. and Ali, B.H. and Zahurin, M. and Mustafa, A.M. and Alhadrami, G. and Bashir, A.K. (2001) Comparative pharmacokinetics of theophylline in camels (Camelus dromedarius) and goats (Caprus hircus). Journal of Veterinary Medicine Series a-Physiology Pathology Clinical Medicine, 48 (10). pp. 581-586. ISSN 0931-184X 10.1046/j.1439-0442.2001.00401.x
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Elsheikh, H.A.
Ali, B.H.
Zahurin, M.
Mustafa, A.M.
Alhadrami, G.
Bashir, A.K.
Comparative pharmacokinetics of theophylline in camels (Camelus dromedarius) and goats (Caprus hircus)
description A comparative randomized crossover study was conducted to determine the pharmacokinetics of theophylline in male and female camels (Camelus dromedarius) and goats (Caprus hircus). Theophylline is an established 'probe drug' to evaluate the drug metabolizing enzyme activity of animals. It was administered by the intravenous (i.v.) route and then intramuscularly (i.m.) at a dose of 2 mg/kg. The concentration of the drug in plasma was measured using a high-performance liquid chromatography (HPLC) technique on samples collected at frequent intervals after administration. Following i.v. injection, die overall elimination rate constant (lambda(z)) in goats was 0.006 +/- 0.00076/min and in camels was 0.0046 +/- 0.0008/min (P < 0.01). The elimination half-life (t(1/2lambdaz)) in goats (112.7 min) was lower than in camels (154.7 min) (P < 0.01). The apparent volume of distribution (V-z) and the total body clearance (Cl) in goats were 1440.1 +/- 166.6 ml/kg and 8.9 +/- 1.4 ml/min/ kg, respectively. The corresponding values in camels were 1720.3 +/- 345.3 ml/kg and 6.1 +/- 1.0 ml/ min/kg, respectively. After i.m. administration, theophylline reached a peak plasma concentration (C-max) of 1.8 +/- 0.1 and 1.7 +/- 0.2 mug/ml at a post-injection dine (T-max) of 67.5 +/- 8.6 and 122.3 +/- 6.7 min in goats and camels, respectively. The mean bioavailability (F) in both goats and camels was 0.9 +/- 0.2. The above data suggest that camels eliminate theophylline at a slower rate than goats.
format Article
author Elsheikh, H.A.
Ali, B.H.
Zahurin, M.
Mustafa, A.M.
Alhadrami, G.
Bashir, A.K.
author_facet Elsheikh, H.A.
Ali, B.H.
Zahurin, M.
Mustafa, A.M.
Alhadrami, G.
Bashir, A.K.
author_sort Elsheikh, H.A.
title Comparative pharmacokinetics of theophylline in camels (Camelus dromedarius) and goats (Caprus hircus)
title_short Comparative pharmacokinetics of theophylline in camels (Camelus dromedarius) and goats (Caprus hircus)
title_full Comparative pharmacokinetics of theophylline in camels (Camelus dromedarius) and goats (Caprus hircus)
title_fullStr Comparative pharmacokinetics of theophylline in camels (Camelus dromedarius) and goats (Caprus hircus)
title_full_unstemmed Comparative pharmacokinetics of theophylline in camels (Camelus dromedarius) and goats (Caprus hircus)
title_sort comparative pharmacokinetics of theophylline in camels (camelus dromedarius) and goats (caprus hircus)
publishDate 2001
url http://eprints.um.edu.my/5105/
_version_ 1643687489562476544
score 13.211869

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