Staff View: Effects of silymarin supplementation on liver and kidney functions: A systematic review and dose-response meta-analysis

Effects of silymarin supplementation on liver and kidney functions: A systematic review and dose-response meta-analysis

It is suggested that supplementation with silymarin (SIL) has beneficial impacts on kidney and liver functions. This systematic review and dose-response meta-analysis assessed the impact of SIL administration on certain hepatic, renal, and oxidative stress markers. A systematic search was conducted...

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Main Authors:	Mohammadi, Shooka, Ashtary-Larky, Damoon, Asbaghi, Omid, Farrokhi, Vida, Jadidi, Yasaman, Mofidi, Fatemeh, Mohammadian, Mehrnaz, Afrisham, Reza
Format:	Article
Published:	Wiley 2024
Subjects:	R Medicine (General)
Online Access:	http://eprints.um.edu.my/47022/ https://doi.org/10.1002/ptr.8173
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spelling	my.um.eprints.470222025-01-08T01:16:17Z http://eprints.um.edu.my/47022/ Effects of silymarin supplementation on liver and kidney functions: A systematic review and dose-response meta-analysis Mohammadi, Shooka Ashtary-Larky, Damoon Asbaghi, Omid Farrokhi, Vida Jadidi, Yasaman Mofidi, Fatemeh Mohammadian, Mehrnaz Afrisham, Reza R Medicine (General) It is suggested that supplementation with silymarin (SIL) has beneficial impacts on kidney and liver functions. This systematic review and dose-response meta-analysis assessed the impact of SIL administration on certain hepatic, renal, and oxidative stress markers. A systematic search was conducted in various databases to identify relevant trials published until January 2023. Randomized controlled trials (RCTs) that evaluated the effects of SIL on kidney and liver markers were included. A random-effects model was used for the analysis and 41 RCTs were included. The pooled results indicated that SIL supplementation led to a significant reduction in serum levels of alkaline phosphatase, alanine transaminase, creatinine, and aspartate aminotransferase, along with a substantial elevation in serum glutathione in the SIL-treated group compared to their untreated counterparts. In addition, there was a nonsignificant decrease in serum levels of gamma-glutamyl transferase, malondialdehyde (MDA), total bilirubin, albumin (Alb), total antioxidant capacity, and blood urea nitrogen. Sub-group analyses revealed a considerable decline in MDA and Alb serum values among SIL-treated participants with liver disease in trials with a longer duration (>= 12 weeks). These findings suggest that SIL may ameliorate certain liver markers with potential hepatoprotective effects, specifically with long-term and high-dose supplementation. However, its nephroprotective effects and impact on oxidative stress markers were not observed. Additional high-quality RCTs with longer durations are required to determine the clinical efficacy of SIL supplementation on renal and oxidative stress markers. Wiley 2024-05 Article PeerReviewed Mohammadi, Shooka and Ashtary-Larky, Damoon and Asbaghi, Omid and Farrokhi, Vida and Jadidi, Yasaman and Mofidi, Fatemeh and Mohammadian, Mehrnaz and Afrisham, Reza (2024) Effects of silymarin supplementation on liver and kidney functions: A systematic review and dose-response meta-analysis. Phytotherapy Research, 38 (5). pp. 2572-2593. ISSN 0951-418X, DOI https://doi.org/10.1002/ptr.8173 <https://doi.org/10.1002/ptr.8173>. https://doi.org/10.1002/ptr.8173 10.1002/ptr.8173
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine (General)
spellingShingle	R Medicine (General) Mohammadi, Shooka Ashtary-Larky, Damoon Asbaghi, Omid Farrokhi, Vida Jadidi, Yasaman Mofidi, Fatemeh Mohammadian, Mehrnaz Afrisham, Reza Effects of silymarin supplementation on liver and kidney functions: A systematic review and dose-response meta-analysis
description	It is suggested that supplementation with silymarin (SIL) has beneficial impacts on kidney and liver functions. This systematic review and dose-response meta-analysis assessed the impact of SIL administration on certain hepatic, renal, and oxidative stress markers. A systematic search was conducted in various databases to identify relevant trials published until January 2023. Randomized controlled trials (RCTs) that evaluated the effects of SIL on kidney and liver markers were included. A random-effects model was used for the analysis and 41 RCTs were included. The pooled results indicated that SIL supplementation led to a significant reduction in serum levels of alkaline phosphatase, alanine transaminase, creatinine, and aspartate aminotransferase, along with a substantial elevation in serum glutathione in the SIL-treated group compared to their untreated counterparts. In addition, there was a nonsignificant decrease in serum levels of gamma-glutamyl transferase, malondialdehyde (MDA), total bilirubin, albumin (Alb), total antioxidant capacity, and blood urea nitrogen. Sub-group analyses revealed a considerable decline in MDA and Alb serum values among SIL-treated participants with liver disease in trials with a longer duration (>= 12 weeks). These findings suggest that SIL may ameliorate certain liver markers with potential hepatoprotective effects, specifically with long-term and high-dose supplementation. However, its nephroprotective effects and impact on oxidative stress markers were not observed. Additional high-quality RCTs with longer durations are required to determine the clinical efficacy of SIL supplementation on renal and oxidative stress markers.
format	Article
author	Mohammadi, Shooka Ashtary-Larky, Damoon Asbaghi, Omid Farrokhi, Vida Jadidi, Yasaman Mofidi, Fatemeh Mohammadian, Mehrnaz Afrisham, Reza
author_facet	Mohammadi, Shooka Ashtary-Larky, Damoon Asbaghi, Omid Farrokhi, Vida Jadidi, Yasaman Mofidi, Fatemeh Mohammadian, Mehrnaz Afrisham, Reza
author_sort	Mohammadi, Shooka
title	Effects of silymarin supplementation on liver and kidney functions: A systematic review and dose-response meta-analysis
title_short	Effects of silymarin supplementation on liver and kidney functions: A systematic review and dose-response meta-analysis
title_full	Effects of silymarin supplementation on liver and kidney functions: A systematic review and dose-response meta-analysis
title_fullStr	Effects of silymarin supplementation on liver and kidney functions: A systematic review and dose-response meta-analysis
title_full_unstemmed	Effects of silymarin supplementation on liver and kidney functions: A systematic review and dose-response meta-analysis
title_sort	effects of silymarin supplementation on liver and kidney functions: a systematic review and dose-response meta-analysis
publisher	Wiley
publishDate	2024
url	http://eprints.um.edu.my/47022/ https://doi.org/10.1002/ptr.8173
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score	13.244413

Effects of silymarin supplementation on liver and kidney functions: A systematic review and dose-response meta-analysis

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