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Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity

In this study, zinc oxide nanoparticles (ZnO-NPs) are synthesized and combined with chitosan (Cs) to create Cs/ZnO-NPs nanomicelles, aiming to investigate their potential as a novel cancer treatment. The ZnO-NPs are produced through a sintering process at temperatures ranging from 300 to 700 degrees...

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Main Authors:	Hamrayev, Hemra, Jazayeri, Seyed Davoud, Yusefi, Mostafa, Brianna, -, Teow, Sin-Yeang, Wu, Yuan Seng, Anwar, Ayaz, Korpayev, Serdar, Kartouzian, Aras, Shameli, Kamyar
Format:	Article
Published:	Wiley 2024
Subjects:	Q Science (General)
Online Access:	http://eprints.um.edu.my/47005/ https://doi.org/10.1002/ppsc.202400009
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spelling	my.um.eprints.470052025-01-08T08:47:58Z http://eprints.um.edu.my/47005/ Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity Hamrayev, Hemra Jazayeri, Seyed Davoud Yusefi, Mostafa Brianna, - Teow, Sin-Yeang Wu, Yuan Seng Anwar, Ayaz Korpayev, Serdar Kartouzian, Aras Shameli, Kamyar Q Science (General) In this study, zinc oxide nanoparticles (ZnO-NPs) are synthesized and combined with chitosan (Cs) to create Cs/ZnO-NPs nanomicelles, aiming to investigate their potential as a novel cancer treatment. The ZnO-NPs are produced through a sintering process at temperatures ranging from 300 to 700 degrees C. The most effective nanoparticles are obtained at 600 degrees C, as determined by X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) analyses, which confirmed their crystallinity and purity. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) are employed to characterize the size and shape of the nanoparticles, revealing predominantly spherical and hexagonal structures with stable dimensions. The cytotoxic effects of the Cs/ZnO-NPs are evaluated against various cancer cell types. The results show that at a concentration of 125 mu g mL-1, the Cs/ZnO-NPs demonstrate significantly higher cancer cell toxicity compared to ZnO-NPs alone, while remaining non-toxic to normal cells. This indicates that Cs/ZnO-NPs have a superior ability to selectively target cancer cells. These findings suggest that Cs/ZnO-NPs nanomicelles hold promise as an effective and safe nanotherapeutic approach in the realm of cancer treatment, meriting further exploration for clinical applications. Pioneering a novel cancer therapy, this research utilizes Cs/ZnO-NPs nanomicelles, showcasing heightened selective toxicity against cancer cells while safeguarding healthy ones. These results open promising paths for safer, more effective cancer treatments, potentially transforming oncological approaches and inspiring advancements in future nanomedicine. image Wiley 2024-08 Article PeerReviewed Hamrayev, Hemra and Jazayeri, Seyed Davoud and Yusefi, Mostafa and Brianna, - and Teow, Sin-Yeang and Wu, Yuan Seng and Anwar, Ayaz and Korpayev, Serdar and Kartouzian, Aras and Shameli, Kamyar (2024) Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity. Particle & Particle Systems Characterization, 41 (8). ISSN 0934-0866, DOI https://doi.org/10.1002/ppsc.202400009 <https://doi.org/10.1002/ppsc.202400009>. https://doi.org/10.1002/ppsc.202400009 10.1002/ppsc.202400009
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	Q Science (General)
spellingShingle	Q Science (General) Hamrayev, Hemra Jazayeri, Seyed Davoud Yusefi, Mostafa Brianna, - Teow, Sin-Yeang Wu, Yuan Seng Anwar, Ayaz Korpayev, Serdar Kartouzian, Aras Shameli, Kamyar Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity
description	In this study, zinc oxide nanoparticles (ZnO-NPs) are synthesized and combined with chitosan (Cs) to create Cs/ZnO-NPs nanomicelles, aiming to investigate their potential as a novel cancer treatment. The ZnO-NPs are produced through a sintering process at temperatures ranging from 300 to 700 degrees C. The most effective nanoparticles are obtained at 600 degrees C, as determined by X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) analyses, which confirmed their crystallinity and purity. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) are employed to characterize the size and shape of the nanoparticles, revealing predominantly spherical and hexagonal structures with stable dimensions. The cytotoxic effects of the Cs/ZnO-NPs are evaluated against various cancer cell types. The results show that at a concentration of 125 mu g mL-1, the Cs/ZnO-NPs demonstrate significantly higher cancer cell toxicity compared to ZnO-NPs alone, while remaining non-toxic to normal cells. This indicates that Cs/ZnO-NPs have a superior ability to selectively target cancer cells. These findings suggest that Cs/ZnO-NPs nanomicelles hold promise as an effective and safe nanotherapeutic approach in the realm of cancer treatment, meriting further exploration for clinical applications. Pioneering a novel cancer therapy, this research utilizes Cs/ZnO-NPs nanomicelles, showcasing heightened selective toxicity against cancer cells while safeguarding healthy ones. These results open promising paths for safer, more effective cancer treatments, potentially transforming oncological approaches and inspiring advancements in future nanomedicine. image
format	Article
author	Hamrayev, Hemra Jazayeri, Seyed Davoud Yusefi, Mostafa Brianna, - Teow, Sin-Yeang Wu, Yuan Seng Anwar, Ayaz Korpayev, Serdar Kartouzian, Aras Shameli, Kamyar
author_facet	Hamrayev, Hemra Jazayeri, Seyed Davoud Yusefi, Mostafa Brianna, - Teow, Sin-Yeang Wu, Yuan Seng Anwar, Ayaz Korpayev, Serdar Kartouzian, Aras Shameli, Kamyar
author_sort	Hamrayev, Hemra
title	Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity
title_short	Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity
title_full	Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity
title_fullStr	Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity
title_full_unstemmed	Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity
title_sort	green chemical approach for the synthesis of zno nanoparticles and investigation of their cytotoxicity
publisher	Wiley
publishDate	2024
url	http://eprints.um.edu.my/47005/ https://doi.org/10.1002/ppsc.202400009
_version_	1821105752558796800
score	13.235362

Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity

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