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Gout Management Using Nanocarrier Systems: A Review

Gout is an inflammatory arthropathy resulting from the deposition of monosodium urate crystals in and around joints, triggering the release of pro-inflammatory cytokines. Some of the key principles for managing gout are encompassing comorbidity screening, gout flare treatment, urate-lowering therapy...

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Main Authors:	Qi, Chia Wen, Nordin, Ummu Umaimah Mohd, Mahmood, Syed, Karusan, Nisha Rata, Khalid, Ramsha, Nordin, Nurdiana, Fornaguera, Cristina, Ahmad, Noraini
Format:	Article
Published:	American Chemical Society 2024
Subjects:	QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica
Online Access:	http://eprints.um.edu.my/46975/ https://doi.org/10.1021/acsanm.3c06079
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spelling	my.um.eprints.469752025-01-09T04:00:58Z http://eprints.um.edu.my/46975/ Gout Management Using Nanocarrier Systems: A Review Qi, Chia Wen Nordin, Ummu Umaimah Mohd Mahmood, Syed Karusan, Nisha Rata Khalid, Ramsha Nordin, Nurdiana Fornaguera, Cristina Ahmad, Noraini QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica Gout is an inflammatory arthropathy resulting from the deposition of monosodium urate crystals in and around joints, triggering the release of pro-inflammatory cytokines. Some of the key principles for managing gout are encompassing comorbidity screening, gout flare treatment, urate-lowering therapy, and anti-inflammatory prophylaxis. One of the major concerns with gout treatment is the side effects of drug due to uncontrolled biodistribution. Nanocarrier systems are utilized to surmount the limitations of current drugs, including not only biodistribution issues but also the stability and bioavailability of the drugs. Nanocarriers as promising drug delivery systems can effectively deliver drugs by specifically targeting inflamed tissues through enhanced permeability and retention effect mediated delivery. Notable examples include liposomes, niosomes, ethosomes, transfersomes, solid lipid nanoparticles, polymeric nanoparticles, nanoemulsions, and liquid crystalline nanoparticles, namely, cubosomes, hexosomes, and spongosomes. These nanocarriers hold great promise as vehicles for transporting poorly therapeutic agents to precise target sites, associated with controlled release capabilities to bolster bioavailability. Preclinical studies have demonstrated the efficacy of nanocarrier-based therapies in reducing inflammation by specifically targeting inflamed tissues, inhibiting urate crystal formation, and improving joint function in animal models of gout. In this review, we explore the main nanocarrier systems, including their respective advantages and drawbacks, and emphasize their role in nanoformulations for advancing gout treatment. The encapsulation of active agents within nanocarriers for gout therapy represents a significant advancement in the pharmaceutical area and nanomedicine application to succeed in the overall context of gout treatment in the near future. American Chemical Society 2024-04 Article PeerReviewed Qi, Chia Wen and Nordin, Ummu Umaimah Mohd and Mahmood, Syed and Karusan, Nisha Rata and Khalid, Ramsha and Nordin, Nurdiana and Fornaguera, Cristina and Ahmad, Noraini (2024) Gout Management Using Nanocarrier Systems: A Review. ACS Applied Nano Materials, 7 (9). pp. 9816-9846. ISSN 2574-0970, DOI https://doi.org/10.1021/acsanm.3c06079 <https://doi.org/10.1021/acsanm.3c06079>. https://doi.org/10.1021/acsanm.3c06079 10.1021/acsanm.3c06079
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica
spellingShingle	QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica Qi, Chia Wen Nordin, Ummu Umaimah Mohd Mahmood, Syed Karusan, Nisha Rata Khalid, Ramsha Nordin, Nurdiana Fornaguera, Cristina Ahmad, Noraini Gout Management Using Nanocarrier Systems: A Review
description	Gout is an inflammatory arthropathy resulting from the deposition of monosodium urate crystals in and around joints, triggering the release of pro-inflammatory cytokines. Some of the key principles for managing gout are encompassing comorbidity screening, gout flare treatment, urate-lowering therapy, and anti-inflammatory prophylaxis. One of the major concerns with gout treatment is the side effects of drug due to uncontrolled biodistribution. Nanocarrier systems are utilized to surmount the limitations of current drugs, including not only biodistribution issues but also the stability and bioavailability of the drugs. Nanocarriers as promising drug delivery systems can effectively deliver drugs by specifically targeting inflamed tissues through enhanced permeability and retention effect mediated delivery. Notable examples include liposomes, niosomes, ethosomes, transfersomes, solid lipid nanoparticles, polymeric nanoparticles, nanoemulsions, and liquid crystalline nanoparticles, namely, cubosomes, hexosomes, and spongosomes. These nanocarriers hold great promise as vehicles for transporting poorly therapeutic agents to precise target sites, associated with controlled release capabilities to bolster bioavailability. Preclinical studies have demonstrated the efficacy of nanocarrier-based therapies in reducing inflammation by specifically targeting inflamed tissues, inhibiting urate crystal formation, and improving joint function in animal models of gout. In this review, we explore the main nanocarrier systems, including their respective advantages and drawbacks, and emphasize their role in nanoformulations for advancing gout treatment. The encapsulation of active agents within nanocarriers for gout therapy represents a significant advancement in the pharmaceutical area and nanomedicine application to succeed in the overall context of gout treatment in the near future.
format	Article
author	Qi, Chia Wen Nordin, Ummu Umaimah Mohd Mahmood, Syed Karusan, Nisha Rata Khalid, Ramsha Nordin, Nurdiana Fornaguera, Cristina Ahmad, Noraini
author_facet	Qi, Chia Wen Nordin, Ummu Umaimah Mohd Mahmood, Syed Karusan, Nisha Rata Khalid, Ramsha Nordin, Nurdiana Fornaguera, Cristina Ahmad, Noraini
author_sort	Qi, Chia Wen
title	Gout Management Using Nanocarrier Systems: A Review
title_short	Gout Management Using Nanocarrier Systems: A Review
title_full	Gout Management Using Nanocarrier Systems: A Review
title_fullStr	Gout Management Using Nanocarrier Systems: A Review
title_full_unstemmed	Gout Management Using Nanocarrier Systems: A Review
title_sort	gout management using nanocarrier systems: a review
publisher	American Chemical Society
publishDate	2024
url	http://eprints.um.edu.my/46975/ https://doi.org/10.1021/acsanm.3c06079
_version_	1821105747525632000
score	13.23648

Gout Management Using Nanocarrier Systems: A Review

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