Staff View: Longitudinal Changes in the Retinal Nerve Fiber Layer Thickness in Amyotrophic Lateral Sclerosis and Parkinson's Disease

Longitudinal Changes in the Retinal Nerve Fiber Layer Thickness in Amyotrophic Lateral Sclerosis and Parkinson's Disease

Background and Purpose There is increasing evidence that the anterior visual pathways are involved in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). This study investigated longitudinal changes in retinal nerve fiber layer (RNFL) thickness...

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Main Authors:	Taufik, Sharifah Azira, Ramli, Norlina, Tan, Ai Huey, Lim, Shen -Yang, Ghani, Mohd Taufiq Abdul, Shahrizaila, Nortina
Format:	Article
Published:	Korean Neurological Association 2024
Subjects:	R Medicine (General)
Online Access:	http://eprints.um.edu.my/46965/ https://doi.org/10.3988/jcn.2023.0353
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spelling	my.um.eprints.469652025-01-13T00:36:42Z http://eprints.um.edu.my/46965/ Longitudinal Changes in the Retinal Nerve Fiber Layer Thickness in Amyotrophic Lateral Sclerosis and Parkinson's Disease Taufik, Sharifah Azira Ramli, Norlina Tan, Ai Huey Lim, Shen -Yang Ghani, Mohd Taufiq Abdul Shahrizaila, Nortina R Medicine (General) Background and Purpose There is increasing evidence that the anterior visual pathways are involved in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). This study investigated longitudinal changes in retinal nerve fiber layer (RNFL) thickness in patients with ALS and PD with the aim of better understanding their roles as biomarkers of disease progression. Methods This study recruited 21 ALS patients, 19 age-matched PD patients, and 21 agematched healthy controls. Patient demographics and clinical scores relating to the respective diseases were documented. The RNFL thickness was measured using optical coherence tomography at baseline and after 6 months. Results At baseline, the RNFL in the superior quadrant was significantly thinner in the patients with ALS than in healthy controls (109.90 +/- 22.41 um vs. 127.81 +/- 17.05 um mean +/- standard deviation], p=0.008). The RNFL thickness did not differ significantly between the ALS and PD patients or between the PD patients and healthy controls. At 6 months, there was further significant RNFL thinning in patients with ALS, for both the overall thickness (baseline: median=94.5 um, range=83.0-106.0 um; follow-up: median=93.5 um, range=82.5-104.5 um, p=0.043) and the thickness in the inferior quadrant (median=126 um, range=109.5-142.5 um; and median=117.5 um, range=98.5-136.5 um; respectively, p=0.032). However, these changes were not correlated with the ALS functional scores. In contrast, the patients with PD did not demonstrate a significant change in RNFL thickness between the two time points. Conclusions The RNFL thickness is a promising biomarker of disease progression in patients with ALS but not in those with PD, which has a slower disease progression. Korean Neurological Association 2024-05 Article PeerReviewed Taufik, Sharifah Azira and Ramli, Norlina and Tan, Ai Huey and Lim, Shen -Yang and Ghani, Mohd Taufiq Abdul and Shahrizaila, Nortina (2024) Longitudinal Changes in the Retinal Nerve Fiber Layer Thickness in Amyotrophic Lateral Sclerosis and Parkinson's Disease. Journal of Clinical Neurology, 20 (3). pp. 285-292. ISSN 1738-6586, DOI https://doi.org/10.3988/jcn.2023.0353 <https://doi.org/10.3988/jcn.2023.0353>. https://doi.org/10.3988/jcn.2023.0353 10.3988/jcn.2023.0353
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine (General)
spellingShingle	R Medicine (General) Taufik, Sharifah Azira Ramli, Norlina Tan, Ai Huey Lim, Shen -Yang Ghani, Mohd Taufiq Abdul Shahrizaila, Nortina Longitudinal Changes in the Retinal Nerve Fiber Layer Thickness in Amyotrophic Lateral Sclerosis and Parkinson's Disease
description	Background and Purpose There is increasing evidence that the anterior visual pathways are involved in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). This study investigated longitudinal changes in retinal nerve fiber layer (RNFL) thickness in patients with ALS and PD with the aim of better understanding their roles as biomarkers of disease progression. Methods This study recruited 21 ALS patients, 19 age-matched PD patients, and 21 agematched healthy controls. Patient demographics and clinical scores relating to the respective diseases were documented. The RNFL thickness was measured using optical coherence tomography at baseline and after 6 months. Results At baseline, the RNFL in the superior quadrant was significantly thinner in the patients with ALS than in healthy controls (109.90 +/- 22.41 um vs. 127.81 +/- 17.05 um mean +/- standard deviation], p=0.008). The RNFL thickness did not differ significantly between the ALS and PD patients or between the PD patients and healthy controls. At 6 months, there was further significant RNFL thinning in patients with ALS, for both the overall thickness (baseline: median=94.5 um, range=83.0-106.0 um; follow-up: median=93.5 um, range=82.5-104.5 um, p=0.043) and the thickness in the inferior quadrant (median=126 um, range=109.5-142.5 um; and median=117.5 um, range=98.5-136.5 um; respectively, p=0.032). However, these changes were not correlated with the ALS functional scores. In contrast, the patients with PD did not demonstrate a significant change in RNFL thickness between the two time points. Conclusions The RNFL thickness is a promising biomarker of disease progression in patients with ALS but not in those with PD, which has a slower disease progression.
format	Article
author	Taufik, Sharifah Azira Ramli, Norlina Tan, Ai Huey Lim, Shen -Yang Ghani, Mohd Taufiq Abdul Shahrizaila, Nortina
author_facet	Taufik, Sharifah Azira Ramli, Norlina Tan, Ai Huey Lim, Shen -Yang Ghani, Mohd Taufiq Abdul Shahrizaila, Nortina
author_sort	Taufik, Sharifah Azira
title	Longitudinal Changes in the Retinal Nerve Fiber Layer Thickness in Amyotrophic Lateral Sclerosis and Parkinson's Disease
title_short	Longitudinal Changes in the Retinal Nerve Fiber Layer Thickness in Amyotrophic Lateral Sclerosis and Parkinson's Disease
title_full	Longitudinal Changes in the Retinal Nerve Fiber Layer Thickness in Amyotrophic Lateral Sclerosis and Parkinson's Disease
title_fullStr	Longitudinal Changes in the Retinal Nerve Fiber Layer Thickness in Amyotrophic Lateral Sclerosis and Parkinson's Disease
title_full_unstemmed	Longitudinal Changes in the Retinal Nerve Fiber Layer Thickness in Amyotrophic Lateral Sclerosis and Parkinson's Disease
title_sort	longitudinal changes in the retinal nerve fiber layer thickness in amyotrophic lateral sclerosis and parkinson's disease
publisher	Korean Neurological Association
publishDate	2024
url	http://eprints.um.edu.my/46965/ https://doi.org/10.3988/jcn.2023.0353
_version_	1821105745896144896
score	13.244413

Longitudinal Changes in the Retinal Nerve Fiber Layer Thickness in Amyotrophic Lateral Sclerosis and Parkinson's Disease

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