Effect of strontium substitution on the properties of mesoporous carbonate apatite for biomedical applications

Mesoporous calcium phosphate based-bioceramics with ionic substitution have attracted attention for treatment of bone diseases and bone regeneration. Carbonate apatite (CO3Ap) is a promising candidate for bone replacement through bone remodelling, similar to that of autologous bone, owing to the che...

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Main Authors: Bang, Le T., Long, Bui D., Lan, Phung X., Shi, Xingling, Thanh, Nguyen T. V., Ramesh, S.
Format: Article
Published: Springer 2024
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Online Access:http://eprints.um.edu.my/46889/
https://doi.org/10.1007/s41779-024-01041-7
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spelling my.um.eprints.468892025-01-16T01:53:12Z http://eprints.um.edu.my/46889/ Effect of strontium substitution on the properties of mesoporous carbonate apatite for biomedical applications Bang, Le T. Long, Bui D. Lan, Phung X. Shi, Xingling Thanh, Nguyen T. V. Ramesh, S. TJ Mechanical engineering and machinery Mesoporous calcium phosphate based-bioceramics with ionic substitution have attracted attention for treatment of bone diseases and bone regeneration. Carbonate apatite (CO3Ap) is a promising candidate for bone replacement through bone remodelling, similar to that of autologous bone, owing to the chemical composition of the bone mineral. In this work, we present a dual approach to synthesize mesoporous carbonate apatite (CO3Ap) and strontium-substituted CO3Ap (Sr-CO3Ap) artificial bone nanocrystals, aiming to assess the impact of strontium on CO3Ap characteristics and biological performance. Mesoporous CO3Ap was created by transforming hard templates composed of CaCO3, while Sr-substituted CaCO3 (Sr-CaCO3) microspheres were formed using an organic complexing agent to induce pore formation. The resulting CO3Ap and Sr-CO3Ap granules exhibited an irregular shape, with rod-like nanocrystals composing their particles. Adsorption/desorption isotherms confirmed the mesoporous nature of the structures, featuring pore sizes ranging from 10 to 50 nm. Specifically, mesoporous CO3Ap displayed slit-like pores, while Sr-CO3Ap showed cylinder-like ones. High-resolution transmission electron microscopy images of Sr-CO3Ap powder revealed mesopores within the particles, with Sr-CO3Ap exhibiting larger pore volume and specific surface area compared to CO3Ap. When osteoblast-like MC3T3-E1 cells were cultured on both CO3Ap and Sr-CO3Ap samples, they demonstrated good cell attachment, proliferation rates, and increased ALP activity, particularly evident at higher strontium concentrations. These findings suggest promising potential for further exploration of mesoporous apatite nanocrystals in bone replacement and drug delivery applications. Springer 2024-09 Article PeerReviewed Bang, Le T. and Long, Bui D. and Lan, Phung X. and Shi, Xingling and Thanh, Nguyen T. V. and Ramesh, S. (2024) Effect of strontium substitution on the properties of mesoporous carbonate apatite for biomedical applications. Journal of the Australian Ceramic Society, 60 (4). pp. 1315-1329. ISSN 2510-1560, DOI https://doi.org/10.1007/s41779-024-01041-7 <https://doi.org/10.1007/s41779-024-01041-7>. https://doi.org/10.1007/s41779-024-01041-7 10.1007/s41779-024-01041-7
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic TJ Mechanical engineering and machinery
spellingShingle TJ Mechanical engineering and machinery
Bang, Le T.
Long, Bui D.
Lan, Phung X.
Shi, Xingling
Thanh, Nguyen T. V.
Ramesh, S.
Effect of strontium substitution on the properties of mesoporous carbonate apatite for biomedical applications
description Mesoporous calcium phosphate based-bioceramics with ionic substitution have attracted attention for treatment of bone diseases and bone regeneration. Carbonate apatite (CO3Ap) is a promising candidate for bone replacement through bone remodelling, similar to that of autologous bone, owing to the chemical composition of the bone mineral. In this work, we present a dual approach to synthesize mesoporous carbonate apatite (CO3Ap) and strontium-substituted CO3Ap (Sr-CO3Ap) artificial bone nanocrystals, aiming to assess the impact of strontium on CO3Ap characteristics and biological performance. Mesoporous CO3Ap was created by transforming hard templates composed of CaCO3, while Sr-substituted CaCO3 (Sr-CaCO3) microspheres were formed using an organic complexing agent to induce pore formation. The resulting CO3Ap and Sr-CO3Ap granules exhibited an irregular shape, with rod-like nanocrystals composing their particles. Adsorption/desorption isotherms confirmed the mesoporous nature of the structures, featuring pore sizes ranging from 10 to 50 nm. Specifically, mesoporous CO3Ap displayed slit-like pores, while Sr-CO3Ap showed cylinder-like ones. High-resolution transmission electron microscopy images of Sr-CO3Ap powder revealed mesopores within the particles, with Sr-CO3Ap exhibiting larger pore volume and specific surface area compared to CO3Ap. When osteoblast-like MC3T3-E1 cells were cultured on both CO3Ap and Sr-CO3Ap samples, they demonstrated good cell attachment, proliferation rates, and increased ALP activity, particularly evident at higher strontium concentrations. These findings suggest promising potential for further exploration of mesoporous apatite nanocrystals in bone replacement and drug delivery applications.
format Article
author Bang, Le T.
Long, Bui D.
Lan, Phung X.
Shi, Xingling
Thanh, Nguyen T. V.
Ramesh, S.
author_facet Bang, Le T.
Long, Bui D.
Lan, Phung X.
Shi, Xingling
Thanh, Nguyen T. V.
Ramesh, S.
author_sort Bang, Le T.
title Effect of strontium substitution on the properties of mesoporous carbonate apatite for biomedical applications
title_short Effect of strontium substitution on the properties of mesoporous carbonate apatite for biomedical applications
title_full Effect of strontium substitution on the properties of mesoporous carbonate apatite for biomedical applications
title_fullStr Effect of strontium substitution on the properties of mesoporous carbonate apatite for biomedical applications
title_full_unstemmed Effect of strontium substitution on the properties of mesoporous carbonate apatite for biomedical applications
title_sort effect of strontium substitution on the properties of mesoporous carbonate apatite for biomedical applications
publisher Springer
publishDate 2024
url http://eprints.um.edu.my/46889/
https://doi.org/10.1007/s41779-024-01041-7
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