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Dengue virus infection and neurological manifestations: an update

Dengue virus is a flavivirus transmitted by the mosquitoes, Aedes aegypti and Aedes albopictus. Dengue infection by all four serotypes (DEN 1 to 4) is endemic globally in regions with tropical and subtropical climates, with an estimated 100-400 million infections annually. Among those hospitalized,...

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Main Authors: Fong, Si-Lei, Wong, Kum-Thong, Tan, Chong-Tin
Format: Article
Published: Oxford University Press 2024
Subjects:
R Medicine (General)
Online Access:http://eprints.um.edu.my/45956/
https://doi.org/10.1093/brain/awad415
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spelling my.um.eprints.459562024-11-15T01:22:12Z http://eprints.um.edu.my/45956/ Dengue virus infection and neurological manifestations: an update Fong, Si-Lei Wong, Kum-Thong Tan, Chong-Tin R Medicine (General) Dengue virus is a flavivirus transmitted by the mosquitoes, Aedes aegypti and Aedes albopictus. Dengue infection by all four serotypes (DEN 1 to 4) is endemic globally in regions with tropical and subtropical climates, with an estimated 100-400 million infections annually. Among those hospitalized, the mortality is about 1%. Neurological involvement has been reported to be about 5%. The spectrum of neurological manifestations spans both the peripheral and central nervous systems. These manifestations could possibly be categorized into those directly related to dengue infection, i.e. acute and chronic encephalitis, indirect complications leading to dengue encephalopathy, and post-infectious syndrome due to immune-mediated reactions, and manifestations with uncertain mechanisms, such as acute transverse myelitis, acute cerebellitis and myositis.The rising trend in global dengue incidence calls for attention to a more explicit definition of each neurological manifestation for more accurate epidemiological data. The actual global burden of dengue infection with neurological manifestation is essential for future planning and execution of strategies, especially in the development of effective antivirals and vaccines against the dengue virus.In this article, we discuss the recent findings of different spectrums of neurological manifestations in dengue infection and provide an update on antiviral and vaccine development and their challenges. Dengue is endemic in tropical and subtropical regions. Fong et al. review neurological manifestations directly and indirectly related to dengue virus infection, and discuss progress and challenges in the development of antivirals and vaccines. Oxford University Press 2024-03 Article PeerReviewed Fong, Si-Lei and Wong, Kum-Thong and Tan, Chong-Tin (2024) Dengue virus infection and neurological manifestations: an update. Brain, 147 (3). pp. 830-838. ISSN 0006-8950, DOI https://doi.org/10.1093/brain/awad415 <https://doi.org/10.1093/brain/awad415>. https://doi.org/10.1093/brain/awad415 10.1093/brain/awad415
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine (General)
spellingShingle R Medicine (General)
Fong, Si-Lei
Wong, Kum-Thong
Tan, Chong-Tin
Dengue virus infection and neurological manifestations: an update
description Dengue virus is a flavivirus transmitted by the mosquitoes, Aedes aegypti and Aedes albopictus. Dengue infection by all four serotypes (DEN 1 to 4) is endemic globally in regions with tropical and subtropical climates, with an estimated 100-400 million infections annually. Among those hospitalized, the mortality is about 1%. Neurological involvement has been reported to be about 5%. The spectrum of neurological manifestations spans both the peripheral and central nervous systems. These manifestations could possibly be categorized into those directly related to dengue infection, i.e. acute and chronic encephalitis, indirect complications leading to dengue encephalopathy, and post-infectious syndrome due to immune-mediated reactions, and manifestations with uncertain mechanisms, such as acute transverse myelitis, acute cerebellitis and myositis.The rising trend in global dengue incidence calls for attention to a more explicit definition of each neurological manifestation for more accurate epidemiological data. The actual global burden of dengue infection with neurological manifestation is essential for future planning and execution of strategies, especially in the development of effective antivirals and vaccines against the dengue virus.In this article, we discuss the recent findings of different spectrums of neurological manifestations in dengue infection and provide an update on antiviral and vaccine development and their challenges. Dengue is endemic in tropical and subtropical regions. Fong et al. review neurological manifestations directly and indirectly related to dengue virus infection, and discuss progress and challenges in the development of antivirals and vaccines.
format Article
author Fong, Si-Lei
Wong, Kum-Thong
Tan, Chong-Tin
author_facet Fong, Si-Lei
Wong, Kum-Thong
Tan, Chong-Tin
author_sort Fong, Si-Lei
title Dengue virus infection and neurological manifestations: an update
title_short Dengue virus infection and neurological manifestations: an update
title_full Dengue virus infection and neurological manifestations: an update
title_fullStr Dengue virus infection and neurological manifestations: an update
title_full_unstemmed Dengue virus infection and neurological manifestations: an update
title_sort dengue virus infection and neurological manifestations: an update
publisher Oxford University Press
publishDate 2024
url http://eprints.um.edu.my/45956/
https://doi.org/10.1093/brain/awad415
_version_ 1816130480976691200
score 13.223943

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