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Analgesic Potential Comparison Between Piperine-Combined Curcumin Patch and Non-Piperine Curcumin Patch: A Pragmatic Trial on Post-Cleft Lip/Palate Surgery Pediatric Patients

Purpose: Despite its well-acknowledged analgesic potential, curcumin's low bioavailability has been recognized. Piperine, a substance naturally contained in pepper, has been known for its effect on increasing curcumin bioavailability. To investigate the analgesic potential of curcumin and piper...

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Main Authors: Maulina, Tantry, Purnomo, Yohanes Yoppy, Khamila, Nadya, Garna, Devy, Sjamsudin, Endang, Cahyanto, Arief
Format: Article
Published: Dove Medical Press 2024
Subjects:
RK Dentistry
Online Access:http://eprints.um.edu.my/45881/
https://doi.org/10.2147/JPR.S463159
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spelling my.um.eprints.458812024-11-13T08:44:21Z http://eprints.um.edu.my/45881/ Analgesic Potential Comparison Between Piperine-Combined Curcumin Patch and Non-Piperine Curcumin Patch: A Pragmatic Trial on Post-Cleft Lip/Palate Surgery Pediatric Patients Maulina, Tantry Purnomo, Yohanes Yoppy Khamila, Nadya Garna, Devy Sjamsudin, Endang Cahyanto, Arief RK Dentistry Purpose: Despite its well-acknowledged analgesic potential, curcumin's low bioavailability has been recognized. Piperine, a substance naturally contained in pepper, has been known for its effect on increasing curcumin bioavailability. To investigate the analgesic potential of curcumin and piperine addition to curcumin patch used as adjuvant therapy in the management of acute postoperative orofacial pain. Patients and Methods: This pragmatic trial recruited 75 patients that underwent oromaxillofacial surgery at Unpad Dental Hospital, Bandung, Indonesia. Research participants were randomly assigned to three different groups: the first group that did not receive any intervention other than the post-operative standard treatment (POST), the second group that received POST and non-piperine curcumin patch, and the third group that received POST and piperine-combined curcumin patch. Participants' pain intensity was evaluated by using the face, leg, activity, cry, and consolability (FLACC) pain scale and salivary prostaglandin-E2 (PGE2) level for two-time points, which were eight hours apart. All data were gathered and analyzed to compare the within and between-group differences. Results: Within groups comparison of the FLACC scores for two evaluation points showed significant differences for all groups (p < 0.01). For salivary PGE2 analysis, a comparison of the non-piperine group to the piperine group also showed significant results. Yet, when all three groups were compared, regardless of the differences, the results were not statistically significant. Conclusion: Despite of the proven efficacy of curcumin patch, the addition of piperine to the curcumin patch in the current study did not provide any significant effects. Further investigation is of importance. Dove Medical Press 2024 Article PeerReviewed Maulina, Tantry and Purnomo, Yohanes Yoppy and Khamila, Nadya and Garna, Devy and Sjamsudin, Endang and Cahyanto, Arief (2024) Analgesic Potential Comparison Between Piperine-Combined Curcumin Patch and Non-Piperine Curcumin Patch: A Pragmatic Trial on Post-Cleft Lip/Palate Surgery Pediatric Patients. Journal of Pain Research, 17. pp. 1903-1915. ISSN 1178-7090, DOI https://doi.org/10.2147/JPR.S463159 <https://doi.org/10.2147/JPR.S463159>. https://doi.org/10.2147/JPR.S463159 10.2147/JPR.S463159
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic RK Dentistry
spellingShingle RK Dentistry
Maulina, Tantry
Purnomo, Yohanes Yoppy
Khamila, Nadya
Garna, Devy
Sjamsudin, Endang
Cahyanto, Arief
Analgesic Potential Comparison Between Piperine-Combined Curcumin Patch and Non-Piperine Curcumin Patch: A Pragmatic Trial on Post-Cleft Lip/Palate Surgery Pediatric Patients
description Purpose: Despite its well-acknowledged analgesic potential, curcumin's low bioavailability has been recognized. Piperine, a substance naturally contained in pepper, has been known for its effect on increasing curcumin bioavailability. To investigate the analgesic potential of curcumin and piperine addition to curcumin patch used as adjuvant therapy in the management of acute postoperative orofacial pain. Patients and Methods: This pragmatic trial recruited 75 patients that underwent oromaxillofacial surgery at Unpad Dental Hospital, Bandung, Indonesia. Research participants were randomly assigned to three different groups: the first group that did not receive any intervention other than the post-operative standard treatment (POST), the second group that received POST and non-piperine curcumin patch, and the third group that received POST and piperine-combined curcumin patch. Participants' pain intensity was evaluated by using the face, leg, activity, cry, and consolability (FLACC) pain scale and salivary prostaglandin-E2 (PGE2) level for two-time points, which were eight hours apart. All data were gathered and analyzed to compare the within and between-group differences. Results: Within groups comparison of the FLACC scores for two evaluation points showed significant differences for all groups (p < 0.01). For salivary PGE2 analysis, a comparison of the non-piperine group to the piperine group also showed significant results. Yet, when all three groups were compared, regardless of the differences, the results were not statistically significant. Conclusion: Despite of the proven efficacy of curcumin patch, the addition of piperine to the curcumin patch in the current study did not provide any significant effects. Further investigation is of importance.
format Article
author Maulina, Tantry
Purnomo, Yohanes Yoppy
Khamila, Nadya
Garna, Devy
Sjamsudin, Endang
Cahyanto, Arief
author_facet Maulina, Tantry
Purnomo, Yohanes Yoppy
Khamila, Nadya
Garna, Devy
Sjamsudin, Endang
Cahyanto, Arief
author_sort Maulina, Tantry
title Analgesic Potential Comparison Between Piperine-Combined Curcumin Patch and Non-Piperine Curcumin Patch: A Pragmatic Trial on Post-Cleft Lip/Palate Surgery Pediatric Patients
title_short Analgesic Potential Comparison Between Piperine-Combined Curcumin Patch and Non-Piperine Curcumin Patch: A Pragmatic Trial on Post-Cleft Lip/Palate Surgery Pediatric Patients
title_full Analgesic Potential Comparison Between Piperine-Combined Curcumin Patch and Non-Piperine Curcumin Patch: A Pragmatic Trial on Post-Cleft Lip/Palate Surgery Pediatric Patients
title_fullStr Analgesic Potential Comparison Between Piperine-Combined Curcumin Patch and Non-Piperine Curcumin Patch: A Pragmatic Trial on Post-Cleft Lip/Palate Surgery Pediatric Patients
title_full_unstemmed Analgesic Potential Comparison Between Piperine-Combined Curcumin Patch and Non-Piperine Curcumin Patch: A Pragmatic Trial on Post-Cleft Lip/Palate Surgery Pediatric Patients
title_sort analgesic potential comparison between piperine-combined curcumin patch and non-piperine curcumin patch: a pragmatic trial on post-cleft lip/palate surgery pediatric patients
publisher Dove Medical Press
publishDate 2024
url http://eprints.um.edu.my/45881/
https://doi.org/10.2147/JPR.S463159
_version_ 1816130471770193920
score 13.223943

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