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Seroprevalence of dengue and chikungunya viruses among urban refugees in Klang Valley, Malaysia

Background: Mosquito-borne diseases pose a significant global public health threat, with Malaysia's Klang Valley experiencing numerous outbreaks in densely populated urban areas.Methods: This study aimed to estimate the seroprevalence of anti-dengue and anti-chikungunya antibodies among urban r...

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Main Authors: Sahimin, Norhidayu, Low, Zhao Xuan, Hassandarvish, Pouya, Mohd Hanapi, Izzah Ruzana, Mohd Zain, Siti Nursheena, Yahaya, Hasmawati, Abu Bakar, Sazaly
Format: Article
Published: Oxford University Press 2024
Subjects:
QH Natural history
R Medicine (General)
Online Access:http://eprints.um.edu.my/45778/
https://doi.org/10.1093/trstmh/trad097
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spelling my.um.eprints.457782024-11-12T02:48:17Z http://eprints.um.edu.my/45778/ Seroprevalence of dengue and chikungunya viruses among urban refugees in Klang Valley, Malaysia Sahimin, Norhidayu Low, Zhao Xuan Hassandarvish, Pouya Mohd Hanapi, Izzah Ruzana Mohd Zain, Siti Nursheena Yahaya, Hasmawati Abu Bakar, Sazaly QH Natural history R Medicine (General) Background: Mosquito-borne diseases pose a significant global public health threat, with Malaysia's Klang Valley experiencing numerous outbreaks in densely populated urban areas.Methods: This study aimed to estimate the seroprevalence of anti-dengue and anti-chikungunya antibodies among urban refugees in the Klang Valley, Malaysia, and identify associated risk factors.Results: High seroprevalence of anti-dengue immunoglobulin G (IgG) and IgM (60.0% confidence interval {CI} 55.39 to 64.48] and 9.2% CI 6.77 to 12.25], respectively) were observed among refugees >18 years of age (chi(2)(2)=11.720, p=0.003), Kachin ethnicity (chi(2)(8)=72.253, p<0.001), without formal education (chi(2)(1)=3.856, p=0.050), homes near waste disposal sites (chi(2)(1)=10.378, p=0.001) and refugees who have experienced flooding (chi(2)(1)=5.460, p=0.019). Meanwhile, the overall seroprevalence of anti-chikungunya IgG and IgM was 9.7% (CI 7.15 to 12.73) and 10.8% (CI 8.09 to 13.93), respectively, with ages 12-18 years (chi(2)(2)=6.075, p=0.048), Rohingya ethnicity (chi(2)(8)=31.631, p<0.001) and homes close to waste disposal sites (chi(2)(1)=3.912, p=0.048) being significant risk factors. Results showed a link to poor environmental living conditions, with an increase in the vector population with higher availability of breeding sites and thus exposure to dengue and chikungunya virus.Conclusions: Health education among the community is the key to disease prevention, as there are no specific antiviral drugs for treatment and limited vaccine availability. Oxford University Press 2024-05 Article PeerReviewed Sahimin, Norhidayu and Low, Zhao Xuan and Hassandarvish, Pouya and Mohd Hanapi, Izzah Ruzana and Mohd Zain, Siti Nursheena and Yahaya, Hasmawati and Abu Bakar, Sazaly (2024) Seroprevalence of dengue and chikungunya viruses among urban refugees in Klang Valley, Malaysia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 118 (5). pp. 328-335. ISSN 0035-9203, DOI https://doi.org/10.1093/trstmh/trad097 <https://doi.org/10.1093/trstmh/trad097>. https://doi.org/10.1093/trstmh/trad097 10.1093/trstmh/trad097
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QH Natural history
R Medicine (General)
spellingShingle QH Natural history
R Medicine (General)
Sahimin, Norhidayu
Low, Zhao Xuan
Hassandarvish, Pouya
Mohd Hanapi, Izzah Ruzana
Mohd Zain, Siti Nursheena
Yahaya, Hasmawati
Abu Bakar, Sazaly
Seroprevalence of dengue and chikungunya viruses among urban refugees in Klang Valley, Malaysia
description Background: Mosquito-borne diseases pose a significant global public health threat, with Malaysia's Klang Valley experiencing numerous outbreaks in densely populated urban areas.Methods: This study aimed to estimate the seroprevalence of anti-dengue and anti-chikungunya antibodies among urban refugees in the Klang Valley, Malaysia, and identify associated risk factors.Results: High seroprevalence of anti-dengue immunoglobulin G (IgG) and IgM (60.0% confidence interval {CI} 55.39 to 64.48] and 9.2% CI 6.77 to 12.25], respectively) were observed among refugees >18 years of age (chi(2)(2)=11.720, p=0.003), Kachin ethnicity (chi(2)(8)=72.253, p<0.001), without formal education (chi(2)(1)=3.856, p=0.050), homes near waste disposal sites (chi(2)(1)=10.378, p=0.001) and refugees who have experienced flooding (chi(2)(1)=5.460, p=0.019). Meanwhile, the overall seroprevalence of anti-chikungunya IgG and IgM was 9.7% (CI 7.15 to 12.73) and 10.8% (CI 8.09 to 13.93), respectively, with ages 12-18 years (chi(2)(2)=6.075, p=0.048), Rohingya ethnicity (chi(2)(8)=31.631, p<0.001) and homes close to waste disposal sites (chi(2)(1)=3.912, p=0.048) being significant risk factors. Results showed a link to poor environmental living conditions, with an increase in the vector population with higher availability of breeding sites and thus exposure to dengue and chikungunya virus.Conclusions: Health education among the community is the key to disease prevention, as there are no specific antiviral drugs for treatment and limited vaccine availability.
format Article
author Sahimin, Norhidayu
Low, Zhao Xuan
Hassandarvish, Pouya
Mohd Hanapi, Izzah Ruzana
Mohd Zain, Siti Nursheena
Yahaya, Hasmawati
Abu Bakar, Sazaly
author_facet Sahimin, Norhidayu
Low, Zhao Xuan
Hassandarvish, Pouya
Mohd Hanapi, Izzah Ruzana
Mohd Zain, Siti Nursheena
Yahaya, Hasmawati
Abu Bakar, Sazaly
author_sort Sahimin, Norhidayu
title Seroprevalence of dengue and chikungunya viruses among urban refugees in Klang Valley, Malaysia
title_short Seroprevalence of dengue and chikungunya viruses among urban refugees in Klang Valley, Malaysia
title_full Seroprevalence of dengue and chikungunya viruses among urban refugees in Klang Valley, Malaysia
title_fullStr Seroprevalence of dengue and chikungunya viruses among urban refugees in Klang Valley, Malaysia
title_full_unstemmed Seroprevalence of dengue and chikungunya viruses among urban refugees in Klang Valley, Malaysia
title_sort seroprevalence of dengue and chikungunya viruses among urban refugees in klang valley, malaysia
publisher Oxford University Press
publishDate 2024
url http://eprints.um.edu.my/45778/
https://doi.org/10.1093/trstmh/trad097
_version_ 1816130458268729344
score 13.244413

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