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Potential Therapeutic Application and Mechanism of Action of Stem Cell-Derived Extracellular Vesicles (EVs) in Systemic Lupus Erythematosus (SLE)

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease that affects nearly 3.41 million people globally, with 90% of the cases affecting women of childbearing age. SLE is a complex disease due to the interplay of various immunological pathways and mechanisms. This scoping review ai...

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Main Authors: Kumar, Sushmitha Rajeev, Sakthiswary, Rajalingham, Lokanathan, Yogeswaran
Format: Article
Published: MDPI 2024
Subjects:
QH Natural history
R Medicine (General)
Online Access:http://eprints.um.edu.my/45688/
https://doi.org/10.3390/ijms25042444
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spelling my.um.eprints.456882024-11-08T07:56:19Z http://eprints.um.edu.my/45688/ Potential Therapeutic Application and Mechanism of Action of Stem Cell-Derived Extracellular Vesicles (EVs) in Systemic Lupus Erythematosus (SLE) Kumar, Sushmitha Rajeev Sakthiswary, Rajalingham Lokanathan, Yogeswaran QH Natural history R Medicine (General) Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease that affects nearly 3.41 million people globally, with 90% of the cases affecting women of childbearing age. SLE is a complex disease due to the interplay of various immunological pathways and mechanisms. This scoping review aims to highlight the latest research findings on the therapeutic mechanisms of action of EVs in SLE. Relevant research articles were identified using the PRISMA framework from databases such as PubMed/MEDLINE (National Library of Medicine), Scopus (Elsevier), and Web of Science: Core Collection (Clarivate Analytics) from July 2023 to October 2023. Eleven studies met the inclusion criteria and thus were included in this scoping review. The findings showed that EVs have therapeutic effects on ameliorating the disease progression of SLE. EVs can reduce the pro-inflammatory cytokines and increase the anti-inflammatory cytokines. Moreover, EVs can increase the levels of regulatory T cells, thus reducing inflammation. EVs also have the potential to regulate B cells to alleviate SLE and reduce its adverse effects. The scoping review has successfully analysed the therapeutic potential in ameliorating the disease progression of SLE. The review also includes prospects to improve the effects of EVs further to increase the therapeutic effects on SLE. MDPI 2024-02 Article PeerReviewed Kumar, Sushmitha Rajeev and Sakthiswary, Rajalingham and Lokanathan, Yogeswaran (2024) Potential Therapeutic Application and Mechanism of Action of Stem Cell-Derived Extracellular Vesicles (EVs) in Systemic Lupus Erythematosus (SLE). International Journal of Molecular Sciences, 25 (4). p. 2444. ISSN 1661-6596, DOI https://doi.org/10.3390/ijms25042444 <https://doi.org/10.3390/ijms25042444>. https://doi.org/10.3390/ijms25042444 10.3390/ijms25042444
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QH Natural history
R Medicine (General)
spellingShingle QH Natural history
R Medicine (General)
Kumar, Sushmitha Rajeev
Sakthiswary, Rajalingham
Lokanathan, Yogeswaran
Potential Therapeutic Application and Mechanism of Action of Stem Cell-Derived Extracellular Vesicles (EVs) in Systemic Lupus Erythematosus (SLE)
description Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease that affects nearly 3.41 million people globally, with 90% of the cases affecting women of childbearing age. SLE is a complex disease due to the interplay of various immunological pathways and mechanisms. This scoping review aims to highlight the latest research findings on the therapeutic mechanisms of action of EVs in SLE. Relevant research articles were identified using the PRISMA framework from databases such as PubMed/MEDLINE (National Library of Medicine), Scopus (Elsevier), and Web of Science: Core Collection (Clarivate Analytics) from July 2023 to October 2023. Eleven studies met the inclusion criteria and thus were included in this scoping review. The findings showed that EVs have therapeutic effects on ameliorating the disease progression of SLE. EVs can reduce the pro-inflammatory cytokines and increase the anti-inflammatory cytokines. Moreover, EVs can increase the levels of regulatory T cells, thus reducing inflammation. EVs also have the potential to regulate B cells to alleviate SLE and reduce its adverse effects. The scoping review has successfully analysed the therapeutic potential in ameliorating the disease progression of SLE. The review also includes prospects to improve the effects of EVs further to increase the therapeutic effects on SLE.
format Article
author Kumar, Sushmitha Rajeev
Sakthiswary, Rajalingham
Lokanathan, Yogeswaran
author_facet Kumar, Sushmitha Rajeev
Sakthiswary, Rajalingham
Lokanathan, Yogeswaran
author_sort Kumar, Sushmitha Rajeev
title Potential Therapeutic Application and Mechanism of Action of Stem Cell-Derived Extracellular Vesicles (EVs) in Systemic Lupus Erythematosus (SLE)
title_short Potential Therapeutic Application and Mechanism of Action of Stem Cell-Derived Extracellular Vesicles (EVs) in Systemic Lupus Erythematosus (SLE)
title_full Potential Therapeutic Application and Mechanism of Action of Stem Cell-Derived Extracellular Vesicles (EVs) in Systemic Lupus Erythematosus (SLE)
title_fullStr Potential Therapeutic Application and Mechanism of Action of Stem Cell-Derived Extracellular Vesicles (EVs) in Systemic Lupus Erythematosus (SLE)
title_full_unstemmed Potential Therapeutic Application and Mechanism of Action of Stem Cell-Derived Extracellular Vesicles (EVs) in Systemic Lupus Erythematosus (SLE)
title_sort potential therapeutic application and mechanism of action of stem cell-derived extracellular vesicles (evs) in systemic lupus erythematosus (sle)
publisher MDPI
publishDate 2024
url http://eprints.um.edu.my/45688/
https://doi.org/10.3390/ijms25042444
_version_ 1816130439633436672
score 13.226497

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