FMO-guided design of darunavir analogs as HIV-1 protease inhibitors
The prevalence of HIV-1 infection continues to pose a significant global public health issue, highlighting the need for antiretroviral drugs that target viral proteins to reduce viral replication. One such target is HIV-1 protease (PR), responsible for cleaving viral polyproteins, leading to the mat...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Published: |
Nature Research
2024
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/45628/ https://doi.org/10.1038/s41598-024-53940-1 |
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