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Non-invasive parameters of autonomic function using beat-to-beat cardiovascular variations and arterial stiffness in hypertensive individuals: a systematic review

PurposeNon-invasive, beat-to-beat variations in physiological indices provide an opportunity for more accessible assessment of autonomic dysfunction. The potential association between the changes in these parameters and arterial stiffness in hypertension remains poorly understood. This systematic re...

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Main Authors:	Ooi, Jia Hui, Lim, Renly, Seng, Hansun, Tan, Maw Pin, Goh, Choon Hian, Lovell, Nigel H., Argha, Ahmadreza, Beh, Hooi Chin, Sari, Nor Ashikin Md, Lim, Einly
Format:	Article
Published:	BMC 2024
Subjects:	R Medicine (General)
Online Access:	http://eprints.um.edu.my/45592/ https://doi.org/10.1186/s12938-024-01202-6
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spelling	my.um.eprints.455922024-11-05T09:13:35Z http://eprints.um.edu.my/45592/ Non-invasive parameters of autonomic function using beat-to-beat cardiovascular variations and arterial stiffness in hypertensive individuals: a systematic review Ooi, Jia Hui Lim, Renly Seng, Hansun Tan, Maw Pin Goh, Choon Hian Lovell, Nigel H. Argha, Ahmadreza Beh, Hooi Chin Sari, Nor Ashikin Md Lim, Einly R Medicine (General) PurposeNon-invasive, beat-to-beat variations in physiological indices provide an opportunity for more accessible assessment of autonomic dysfunction. The potential association between the changes in these parameters and arterial stiffness in hypertension remains poorly understood. This systematic review aims to investigate the association between non-invasive indicators of autonomic function based on beat-to-beat cardiovascular signals with arterial stiffness in individuals with hypertension. MethodsFour electronic databases were searched from inception to June 2022. Studies that investigated non-invasive parameters of arterial stiffness and autonomic function using beat-to-beat cardiovascular signals over a period of > 5min were included. Study quality was assessed using the STROBE criteria. Two authors screened the titles, abstracts, and full texts independently. ResultsNineteen studies met the inclusion criteria. A comprehensive overview of experimental design for assessing autonomic function in terms of baroreflex sensitivity and beat-to-beat cardiovascular variabilities, as well as arterial stiffness, was presented. Alterations in non-invasive indicators of autonomic function, which included baroreflex sensitivity, beat-to-beat cardiovascular variabilities and hemodynamic changes in response to autonomic challenges, as well as arterial stiffness, were identified in individuals with hypertension. A mixed result was found in terms of the association between non-invasive quantitative autonomic indices and arterial stiffness in hypertensive individuals. Nine out of 12 studies which quantified baroreflex sensitivity revealed a significant association with arterial stiffness parameters. Three studies estimated beat-to-beat heart rate variability and only one study reported a significant relationship with arterial stiffness indices. Three out of five studies which studied beat-to-beat blood pressure variability showed a significant association with arterial structural changes. One study revealed that hemodynamic changes in response to autonomic challenges were significantly correlated with arterial stiffness parameters. ConclusionsThe current review demonstrated alteration in autonomic function, which encompasses both the sympathetic and parasympathetic modulation of sinus node function and vasomotor tone (derived from beat-to-beat cardiovascular signals) in hypertension, and a significant association between some of these parameters with arterial stiffness. By employing non-invasive measurements to monitor changes in autonomic function and arterial remodeling in individuals with hypertension, we would be able to enhance our ability to identify individuals at high risk of cardiovascular disease. Understanding the intricate relationships among these cardiovascular variability measures and arterial stiffness could contribute toward better individualized treatment for hypertension in the future.Systematic review registration: PROSPERO ID: CRD42022336703. Date of registration: 12/06/2022. BMC 2024-02 Article PeerReviewed Ooi, Jia Hui and Lim, Renly and Seng, Hansun and Tan, Maw Pin and Goh, Choon Hian and Lovell, Nigel H. and Argha, Ahmadreza and Beh, Hooi Chin and Sari, Nor Ashikin Md and Lim, Einly (2024) Non-invasive parameters of autonomic function using beat-to-beat cardiovascular variations and arterial stiffness in hypertensive individuals: a systematic review. BioMedical Engineering OnLine, 23 (1). p. 23. ISSN 1475-925X, DOI https://doi.org/10.1186/s12938-024-01202-6 <https://doi.org/10.1186/s12938-024-01202-6>. https://doi.org/10.1186/s12938-024-01202-6 10.1186/s12938-024-01202-6
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine (General)
spellingShingle	R Medicine (General) Ooi, Jia Hui Lim, Renly Seng, Hansun Tan, Maw Pin Goh, Choon Hian Lovell, Nigel H. Argha, Ahmadreza Beh, Hooi Chin Sari, Nor Ashikin Md Lim, Einly Non-invasive parameters of autonomic function using beat-to-beat cardiovascular variations and arterial stiffness in hypertensive individuals: a systematic review
description	PurposeNon-invasive, beat-to-beat variations in physiological indices provide an opportunity for more accessible assessment of autonomic dysfunction. The potential association between the changes in these parameters and arterial stiffness in hypertension remains poorly understood. This systematic review aims to investigate the association between non-invasive indicators of autonomic function based on beat-to-beat cardiovascular signals with arterial stiffness in individuals with hypertension. MethodsFour electronic databases were searched from inception to June 2022. Studies that investigated non-invasive parameters of arterial stiffness and autonomic function using beat-to-beat cardiovascular signals over a period of > 5min were included. Study quality was assessed using the STROBE criteria. Two authors screened the titles, abstracts, and full texts independently. ResultsNineteen studies met the inclusion criteria. A comprehensive overview of experimental design for assessing autonomic function in terms of baroreflex sensitivity and beat-to-beat cardiovascular variabilities, as well as arterial stiffness, was presented. Alterations in non-invasive indicators of autonomic function, which included baroreflex sensitivity, beat-to-beat cardiovascular variabilities and hemodynamic changes in response to autonomic challenges, as well as arterial stiffness, were identified in individuals with hypertension. A mixed result was found in terms of the association between non-invasive quantitative autonomic indices and arterial stiffness in hypertensive individuals. Nine out of 12 studies which quantified baroreflex sensitivity revealed a significant association with arterial stiffness parameters. Three studies estimated beat-to-beat heart rate variability and only one study reported a significant relationship with arterial stiffness indices. Three out of five studies which studied beat-to-beat blood pressure variability showed a significant association with arterial structural changes. One study revealed that hemodynamic changes in response to autonomic challenges were significantly correlated with arterial stiffness parameters. ConclusionsThe current review demonstrated alteration in autonomic function, which encompasses both the sympathetic and parasympathetic modulation of sinus node function and vasomotor tone (derived from beat-to-beat cardiovascular signals) in hypertension, and a significant association between some of these parameters with arterial stiffness. By employing non-invasive measurements to monitor changes in autonomic function and arterial remodeling in individuals with hypertension, we would be able to enhance our ability to identify individuals at high risk of cardiovascular disease. Understanding the intricate relationships among these cardiovascular variability measures and arterial stiffness could contribute toward better individualized treatment for hypertension in the future.Systematic review registration: PROSPERO ID: CRD42022336703. Date of registration: 12/06/2022.
format	Article
author	Ooi, Jia Hui Lim, Renly Seng, Hansun Tan, Maw Pin Goh, Choon Hian Lovell, Nigel H. Argha, Ahmadreza Beh, Hooi Chin Sari, Nor Ashikin Md Lim, Einly
author_facet	Ooi, Jia Hui Lim, Renly Seng, Hansun Tan, Maw Pin Goh, Choon Hian Lovell, Nigel H. Argha, Ahmadreza Beh, Hooi Chin Sari, Nor Ashikin Md Lim, Einly
author_sort	Ooi, Jia Hui
title	Non-invasive parameters of autonomic function using beat-to-beat cardiovascular variations and arterial stiffness in hypertensive individuals: a systematic review
title_short	Non-invasive parameters of autonomic function using beat-to-beat cardiovascular variations and arterial stiffness in hypertensive individuals: a systematic review
title_full	Non-invasive parameters of autonomic function using beat-to-beat cardiovascular variations and arterial stiffness in hypertensive individuals: a systematic review
title_fullStr	Non-invasive parameters of autonomic function using beat-to-beat cardiovascular variations and arterial stiffness in hypertensive individuals: a systematic review
title_full_unstemmed	Non-invasive parameters of autonomic function using beat-to-beat cardiovascular variations and arterial stiffness in hypertensive individuals: a systematic review
title_sort	non-invasive parameters of autonomic function using beat-to-beat cardiovascular variations and arterial stiffness in hypertensive individuals: a systematic review
publisher	BMC
publishDate	2024
url	http://eprints.um.edu.my/45592/ https://doi.org/10.1186/s12938-024-01202-6
_version_	1814933277702619136
score	13.211869

Non-invasive parameters of autonomic function using beat-to-beat cardiovascular variations and arterial stiffness in hypertensive individuals: a systematic review

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