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Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity

The application of porous bioactive ceramics as bone substitutes requires their effective osseointegration, which relies on specific physical and biological properties. In this study, we developed porous magnesium-doped hydroxyapatite (MgHA) ceramics with four different magnesium concentrations (0.2...

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Main Authors:	Sopyan, Iis, Toibah, Abdul Rahim, Ramesh, Singh, Mel, Maizirwan, Alqap, Asep Sofwan Faturahman
Format:	Article
Published:	Elsevier 2024
Subjects:	TJ Mechanical engineering and machinery TP Chemical technology
Online Access:	http://eprints.um.edu.my/45566/ https://doi.org/10.1016/j.ceramint.2023.12.413
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spelling	my.um.eprints.455662024-10-29T08:07:20Z http://eprints.um.edu.my/45566/ Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity Sopyan, Iis Toibah, Abdul Rahim Ramesh, Singh Mel, Maizirwan Alqap, Asep Sofwan Faturahman TJ Mechanical engineering and machinery TP Chemical technology The application of porous bioactive ceramics as bone substitutes requires their effective osseointegration, which relies on specific physical and biological properties. In this study, we developed porous magnesium-doped hydroxyapatite (MgHA) ceramics with four different magnesium concentrations (0.25, 2, 5 and 10 mol%). The ceramics were prepared through the polymeric replication sponge method and subjected to physical and biological characterizations. Upon sintering, the porous 10 mol% MgHA ceramics exhibited increased densification, which resulted in the highest compressive strength of 2.17 MPa at the lowest porosity of 31 %. The porous samples were analysed via microcomputed tomography. The scaffolds with 0.25 and 10 mol% Mg doping concentrations were selected to elucidate the influence of Mg on morphometric parameters and biological properties at two distinct levels. The high level of Mg doping led to considerable improvements in relative bone volume, connectivity density, trabecular number and trabecular thickness. Cell attachment and proliferation tests using Vero cell lines were conducted on both samples to investigate the correlations between their morphometric parameters and bioactivities. Substantially more cells attached to and proliferated on the surface of the 10 mol% MgHA ceramics compared with those on the ceramics containing 0.25 mol% MgHA. In summary, our study underscores the effectiveness of Mg incorporation in improving the physical and biological properties of porous HA ceramics, which makes them promising candidates for bone substitute applications. Elsevier 2024-04 Article PeerReviewed Sopyan, Iis and Toibah, Abdul Rahim and Ramesh, Singh and Mel, Maizirwan and Alqap, Asep Sofwan Faturahman (2024) Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity. Ceramics International, 50 (7, A). pp. 10967-10973. ISSN 0272-8842, DOI https://doi.org/10.1016/j.ceramint.2023.12.413 <https://doi.org/10.1016/j.ceramint.2023.12.413>. https://doi.org/10.1016/j.ceramint.2023.12.413 10.1016/j.ceramint.2023.12.413
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	TJ Mechanical engineering and machinery TP Chemical technology
spellingShingle	TJ Mechanical engineering and machinery TP Chemical technology Sopyan, Iis Toibah, Abdul Rahim Ramesh, Singh Mel, Maizirwan Alqap, Asep Sofwan Faturahman Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity
description	The application of porous bioactive ceramics as bone substitutes requires their effective osseointegration, which relies on specific physical and biological properties. In this study, we developed porous magnesium-doped hydroxyapatite (MgHA) ceramics with four different magnesium concentrations (0.25, 2, 5 and 10 mol%). The ceramics were prepared through the polymeric replication sponge method and subjected to physical and biological characterizations. Upon sintering, the porous 10 mol% MgHA ceramics exhibited increased densification, which resulted in the highest compressive strength of 2.17 MPa at the lowest porosity of 31 %. The porous samples were analysed via microcomputed tomography. The scaffolds with 0.25 and 10 mol% Mg doping concentrations were selected to elucidate the influence of Mg on morphometric parameters and biological properties at two distinct levels. The high level of Mg doping led to considerable improvements in relative bone volume, connectivity density, trabecular number and trabecular thickness. Cell attachment and proliferation tests using Vero cell lines were conducted on both samples to investigate the correlations between their morphometric parameters and bioactivities. Substantially more cells attached to and proliferated on the surface of the 10 mol% MgHA ceramics compared with those on the ceramics containing 0.25 mol% MgHA. In summary, our study underscores the effectiveness of Mg incorporation in improving the physical and biological properties of porous HA ceramics, which makes them promising candidates for bone substitute applications.
format	Article
author	Sopyan, Iis Toibah, Abdul Rahim Ramesh, Singh Mel, Maizirwan Alqap, Asep Sofwan Faturahman
author_facet	Sopyan, Iis Toibah, Abdul Rahim Ramesh, Singh Mel, Maizirwan Alqap, Asep Sofwan Faturahman
author_sort	Sopyan, Iis
title	Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity
title_short	Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity
title_full	Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity
title_fullStr	Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity
title_full_unstemmed	Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity
title_sort	magnesium-enhanced porous hydroxyapatite ceramics: morphometric parameters, physical properties and bioactivity
publisher	Elsevier
publishDate	2024
url	http://eprints.um.edu.my/45566/ https://doi.org/10.1016/j.ceramint.2023.12.413
_version_	1814933244329590784
score	13.211869

Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity

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