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Photoactivated riboflavin inhibits planktonic and biofilm growth of Candida albicans and non-albicans Candida species

Fungal infections caused by Candida species pose a serious threat to humankind. Antibiotics abuse and the ability of Candida species to form biofilm have escalated the emergence of drug resistance in clinical settings and hence, rendered it more difficult to treat Candida -related diseases. Lethal e...

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Main Authors: Farah, Nuratiqah, Lim, Chee Woei, Chin, Voon Kin, Chong, Pei Pei, Basir, Rusliza, Yeo, Wendy Wai Yeng, Tay, Sun Tee, Choo, Sulin, Lee, Tze Yan
Format: Article
Published: Elsevier 2024
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R Medicine
Online Access:http://eprints.um.edu.my/45172/
https://doi.org/10.1016/j.micpath.2024.106665
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spelling my.um.eprints.451722024-09-20T05:12:15Z http://eprints.um.edu.my/45172/ Photoactivated riboflavin inhibits planktonic and biofilm growth of Candida albicans and non-albicans Candida species Farah, Nuratiqah Lim, Chee Woei Chin, Voon Kin Chong, Pei Pei Basir, Rusliza Yeo, Wendy Wai Yeng Tay, Sun Tee Choo, Sulin Lee, Tze Yan R Medicine Fungal infections caused by Candida species pose a serious threat to humankind. Antibiotics abuse and the ability of Candida species to form biofilm have escalated the emergence of drug resistance in clinical settings and hence, rendered it more difficult to treat Candida -related diseases. Lethal effects of Candida infection are often due to inefficacy of antimicrobial treatments and failure of host immune response to clear infections. Previous studies have shown that a combination of riboflavin with UVA (riboflavin/UVA) light demonstrate candidacidal activity albeit its mechanism of actions remain elusive. Thus, this study sought to investigate antifungal and antibiofilm properties by combining riboflavin with UVA against Candida albicans and non- albicans Candida species. The MIC 20 for the fluconazole and riboflavin/UVA against the Candida species tested was within the range of 0.125 -2 mu g/mL while the SMIC 50 was 32 mu g/mL. Present findings indicate that the inhibitory activities exerted by riboflavin/UVA towards planktonic cells are slightly less effective as compared to controls. However, the efficacy of the combination towards Candida species biofilms showed otherwise. Inhibitory effects exerted by riboflavin/UVA towards most of the tested Candida species biofilms points towards a variation in mode of action that could make it an ideal alternative therapeutic for biofilm-related infections. Elsevier 2024-06 Article PeerReviewed Farah, Nuratiqah and Lim, Chee Woei and Chin, Voon Kin and Chong, Pei Pei and Basir, Rusliza and Yeo, Wendy Wai Yeng and Tay, Sun Tee and Choo, Sulin and Lee, Tze Yan (2024) Photoactivated riboflavin inhibits planktonic and biofilm growth of Candida albicans and non-albicans Candida species. Microbial Pathogenesis, 191. p. 106665. ISSN 0882-4010, DOI https://doi.org/10.1016/j.micpath.2024.106665 <https://doi.org/10.1016/j.micpath.2024.106665>. https://doi.org/10.1016/j.micpath.2024.106665 10.1016/j.micpath.2024.106665
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Farah, Nuratiqah
Lim, Chee Woei
Chin, Voon Kin
Chong, Pei Pei
Basir, Rusliza
Yeo, Wendy Wai Yeng
Tay, Sun Tee
Choo, Sulin
Lee, Tze Yan
Photoactivated riboflavin inhibits planktonic and biofilm growth of Candida albicans and non-albicans Candida species
description Fungal infections caused by Candida species pose a serious threat to humankind. Antibiotics abuse and the ability of Candida species to form biofilm have escalated the emergence of drug resistance in clinical settings and hence, rendered it more difficult to treat Candida -related diseases. Lethal effects of Candida infection are often due to inefficacy of antimicrobial treatments and failure of host immune response to clear infections. Previous studies have shown that a combination of riboflavin with UVA (riboflavin/UVA) light demonstrate candidacidal activity albeit its mechanism of actions remain elusive. Thus, this study sought to investigate antifungal and antibiofilm properties by combining riboflavin with UVA against Candida albicans and non- albicans Candida species. The MIC 20 for the fluconazole and riboflavin/UVA against the Candida species tested was within the range of 0.125 -2 mu g/mL while the SMIC 50 was 32 mu g/mL. Present findings indicate that the inhibitory activities exerted by riboflavin/UVA towards planktonic cells are slightly less effective as compared to controls. However, the efficacy of the combination towards Candida species biofilms showed otherwise. Inhibitory effects exerted by riboflavin/UVA towards most of the tested Candida species biofilms points towards a variation in mode of action that could make it an ideal alternative therapeutic for biofilm-related infections.
format Article
author Farah, Nuratiqah
Lim, Chee Woei
Chin, Voon Kin
Chong, Pei Pei
Basir, Rusliza
Yeo, Wendy Wai Yeng
Tay, Sun Tee
Choo, Sulin
Lee, Tze Yan
author_facet Farah, Nuratiqah
Lim, Chee Woei
Chin, Voon Kin
Chong, Pei Pei
Basir, Rusliza
Yeo, Wendy Wai Yeng
Tay, Sun Tee
Choo, Sulin
Lee, Tze Yan
author_sort Farah, Nuratiqah
title Photoactivated riboflavin inhibits planktonic and biofilm growth of Candida albicans and non-albicans Candida species
title_short Photoactivated riboflavin inhibits planktonic and biofilm growth of Candida albicans and non-albicans Candida species
title_full Photoactivated riboflavin inhibits planktonic and biofilm growth of Candida albicans and non-albicans Candida species
title_fullStr Photoactivated riboflavin inhibits planktonic and biofilm growth of Candida albicans and non-albicans Candida species
title_full_unstemmed Photoactivated riboflavin inhibits planktonic and biofilm growth of Candida albicans and non-albicans Candida species
title_sort photoactivated riboflavin inhibits planktonic and biofilm growth of candida albicans and non-albicans candida species
publisher Elsevier
publishDate 2024
url http://eprints.um.edu.my/45172/
https://doi.org/10.1016/j.micpath.2024.106665
_version_ 1811682097566318592
score 13.211869

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