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Control of electrical and calcium alternans in a one-dimensional cardiac cable

Cardiac alternans is a beat-to-beat alternation in the electrical properties of the heart, such as membrane potential and intracellular calcium (Ca) cycling in myocytes. Due to the bi-directional coupling between voltage and calcium, it is not easy to decide which mechanism drives the alternans and...

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Main Authors: Keong, Jin, Lan, Boon Leong, Lim, Einly, Le, Duy-Manh, Liang, Shiuan-Ni
Format: Article
Published: Springer Science and Business Media Deutschland GmbH 2024
Subjects:
R Medicine
T Technology (General)
TA Engineering (General). Civil engineering (General)
Online Access:http://eprints.um.edu.my/44997/
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spelling my.um.eprints.449972024-04-16T02:31:26Z http://eprints.um.edu.my/44997/ Control of electrical and calcium alternans in a one-dimensional cardiac cable Keong, Jin Lan, Boon Leong Lim, Einly Le, Duy-Manh Liang, Shiuan-Ni R Medicine T Technology (General) TA Engineering (General). Civil engineering (General) Cardiac alternans is a beat-to-beat alternation in the electrical properties of the heart, such as membrane potential and intracellular calcium (Ca) cycling in myocytes. Due to the bi-directional coupling between voltage and calcium, it is not easy to decide which mechanism drives the alternans and thus, affect the effectiveness of controlling alternans. In this study, the control of cardiac alternans in a one-dimensional short cable was investigated numerically using the T± ϵ feedback control, where T is the basic cycle length and ϵ is a pre-set control parameter. The effectiveness of controlling alternans between action potential duration (APD) and peak value of intracellular calcium concentration (peak-Ca) being used as the feedback control variables were compared. Results showed that the effectiveness of APD-based and Ca-based feedback controls were the same when ϵ was less than the critical value (ϵc ), however, the APD-based control performed better than the Ca-based feedback control when ϵ&gt; ϵc. This study may improve the understanding of which method is a better feedback control and lead to the development of a better alternans control scheme. © 2024, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. Springer Science and Business Media Deutschland GmbH 2024 Article PeerReviewed Keong, Jin and Lan, Boon Leong and Lim, Einly and Le, Duy-Manh and Liang, Shiuan-Ni (2024) Control of electrical and calcium alternans in a one-dimensional cardiac cable. Communications in Computer and Information Science, 1912 C. 441 – 451. ISSN 1865-0929, DOI https://doi.org/10.1007/978-981-99-7243-2_36 <https://doi.org/10.1007/978-981-99-7243-2_36>. 10.1007/978-981-99-7243-2_36
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
T Technology (General)
TA Engineering (General). Civil engineering (General)
spellingShingle R Medicine
T Technology (General)
TA Engineering (General). Civil engineering (General)
Keong, Jin
Lan, Boon Leong
Lim, Einly
Le, Duy-Manh
Liang, Shiuan-Ni
Control of electrical and calcium alternans in a one-dimensional cardiac cable
description Cardiac alternans is a beat-to-beat alternation in the electrical properties of the heart, such as membrane potential and intracellular calcium (Ca) cycling in myocytes. Due to the bi-directional coupling between voltage and calcium, it is not easy to decide which mechanism drives the alternans and thus, affect the effectiveness of controlling alternans. In this study, the control of cardiac alternans in a one-dimensional short cable was investigated numerically using the T± ϵ feedback control, where T is the basic cycle length and ϵ is a pre-set control parameter. The effectiveness of controlling alternans between action potential duration (APD) and peak value of intracellular calcium concentration (peak-Ca) being used as the feedback control variables were compared. Results showed that the effectiveness of APD-based and Ca-based feedback controls were the same when ϵ was less than the critical value (ϵc ), however, the APD-based control performed better than the Ca-based feedback control when ϵ&gt; ϵc. This study may improve the understanding of which method is a better feedback control and lead to the development of a better alternans control scheme. © 2024, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
format Article
author Keong, Jin
Lan, Boon Leong
Lim, Einly
Le, Duy-Manh
Liang, Shiuan-Ni
author_facet Keong, Jin
Lan, Boon Leong
Lim, Einly
Le, Duy-Manh
Liang, Shiuan-Ni
author_sort Keong, Jin
title Control of electrical and calcium alternans in a one-dimensional cardiac cable
title_short Control of electrical and calcium alternans in a one-dimensional cardiac cable
title_full Control of electrical and calcium alternans in a one-dimensional cardiac cable
title_fullStr Control of electrical and calcium alternans in a one-dimensional cardiac cable
title_full_unstemmed Control of electrical and calcium alternans in a one-dimensional cardiac cable
title_sort control of electrical and calcium alternans in a one-dimensional cardiac cable
publisher Springer Science and Business Media Deutschland GmbH
publishDate 2024
url http://eprints.um.edu.my/44997/
_version_ 1797906867051036672
score 13.211869

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