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Non-classical Bordetella sp. (closely related to Bordetella hinzii and Bordetella pseudohinzii) lower respiratory tract infection in a patient with extensive bronchiectasis: A case report

An increasing number of reports have described the pathogenic nature of several non-classical Bordetella spp. Among them, Bordetella hinzii and Bordetella pseudohinzii have been implicated in a myriad of respiratory-associated infections in humans and animals. We report the isolation of a geneticall...

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Main Authors: Loong, Shih Keng, Liam, Chong Kin, Karunakaran, Rina, Tan, Kim-Kee, Mahfodz, Nur Hidayana, AbuBakar, Sazaly
Format: Article
Published: SAGE Publications 2024
Subjects:
QR Microbiology
QR355 Virology
R Medicine (General)
Online Access:http://eprints.um.edu.my/44200/
https://doi.org/10.1177/03000605231214464
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spelling my.um.eprints.442002024-06-20T09:16:10Z http://eprints.um.edu.my/44200/ Non-classical Bordetella sp. (closely related to Bordetella hinzii and Bordetella pseudohinzii) lower respiratory tract infection in a patient with extensive bronchiectasis: A case report Loong, Shih Keng Liam, Chong Kin Karunakaran, Rina Tan, Kim-Kee Mahfodz, Nur Hidayana AbuBakar, Sazaly QR Microbiology QR355 Virology R Medicine (General) An increasing number of reports have described the pathogenic nature of several non-classical Bordetella spp. Among them, Bordetella hinzii and Bordetella pseudohinzii have been implicated in a myriad of respiratory-associated infections in humans and animals. We report the isolation of a genetically close relative of B. hinzii and B. pseudohinzii from the sputum of a woman in her early 60s with extensive bronchiectasis who presented with fever and brown colored sputum. The isolate had initially been identified as Bordetella avium by API 20NE, the identification system for non-enteric Gram-negative rod bacteria. Sequencing of the 16S rDNA, ompA, nrdA, and genes used in the Bordetella multilocus sequence typing scheme could not resolve the identity of this Bordetella isolate. Whole-genome single nucleotide polymorphism analysis positioned the isolate between B. hinzii and B. pseudohinzii in the phylogenetic tree, forming a distinct cluster. Whole-genome sequencing enabled the further identification of this rare organism, and should be considered for wider applications, especially the confirmation of organism identity in the clinical diagnostic microbiology laboratory. SAGE Publications 2024-01 Article PeerReviewed Loong, Shih Keng and Liam, Chong Kin and Karunakaran, Rina and Tan, Kim-Kee and Mahfodz, Nur Hidayana and AbuBakar, Sazaly (2024) Non-classical Bordetella sp. (closely related to Bordetella hinzii and Bordetella pseudohinzii) lower respiratory tract infection in a patient with extensive bronchiectasis: A case report. Journal of International Medical Research, 52 (1). ISSN 0300-0605, DOI https://doi.org/10.1177/03000605231214464 <https://doi.org/10.1177/03000605231214464>. https://doi.org/10.1177/03000605231214464 10.1177/03000605231214464
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QR Microbiology
QR355 Virology
R Medicine (General)
spellingShingle QR Microbiology
QR355 Virology
R Medicine (General)
Loong, Shih Keng
Liam, Chong Kin
Karunakaran, Rina
Tan, Kim-Kee
Mahfodz, Nur Hidayana
AbuBakar, Sazaly
Non-classical Bordetella sp. (closely related to Bordetella hinzii and Bordetella pseudohinzii) lower respiratory tract infection in a patient with extensive bronchiectasis: A case report
description An increasing number of reports have described the pathogenic nature of several non-classical Bordetella spp. Among them, Bordetella hinzii and Bordetella pseudohinzii have been implicated in a myriad of respiratory-associated infections in humans and animals. We report the isolation of a genetically close relative of B. hinzii and B. pseudohinzii from the sputum of a woman in her early 60s with extensive bronchiectasis who presented with fever and brown colored sputum. The isolate had initially been identified as Bordetella avium by API 20NE, the identification system for non-enteric Gram-negative rod bacteria. Sequencing of the 16S rDNA, ompA, nrdA, and genes used in the Bordetella multilocus sequence typing scheme could not resolve the identity of this Bordetella isolate. Whole-genome single nucleotide polymorphism analysis positioned the isolate between B. hinzii and B. pseudohinzii in the phylogenetic tree, forming a distinct cluster. Whole-genome sequencing enabled the further identification of this rare organism, and should be considered for wider applications, especially the confirmation of organism identity in the clinical diagnostic microbiology laboratory.
format Article
author Loong, Shih Keng
Liam, Chong Kin
Karunakaran, Rina
Tan, Kim-Kee
Mahfodz, Nur Hidayana
AbuBakar, Sazaly
author_facet Loong, Shih Keng
Liam, Chong Kin
Karunakaran, Rina
Tan, Kim-Kee
Mahfodz, Nur Hidayana
AbuBakar, Sazaly
author_sort Loong, Shih Keng
title Non-classical Bordetella sp. (closely related to Bordetella hinzii and Bordetella pseudohinzii) lower respiratory tract infection in a patient with extensive bronchiectasis: A case report
title_short Non-classical Bordetella sp. (closely related to Bordetella hinzii and Bordetella pseudohinzii) lower respiratory tract infection in a patient with extensive bronchiectasis: A case report
title_full Non-classical Bordetella sp. (closely related to Bordetella hinzii and Bordetella pseudohinzii) lower respiratory tract infection in a patient with extensive bronchiectasis: A case report
title_fullStr Non-classical Bordetella sp. (closely related to Bordetella hinzii and Bordetella pseudohinzii) lower respiratory tract infection in a patient with extensive bronchiectasis: A case report
title_full_unstemmed Non-classical Bordetella sp. (closely related to Bordetella hinzii and Bordetella pseudohinzii) lower respiratory tract infection in a patient with extensive bronchiectasis: A case report
title_sort non-classical bordetella sp. (closely related to bordetella hinzii and bordetella pseudohinzii) lower respiratory tract infection in a patient with extensive bronchiectasis: a case report
publisher SAGE Publications
publishDate 2024
url http://eprints.um.edu.my/44200/
https://doi.org/10.1177/03000605231214464
_version_ 1805881134099202048
score 13.211869

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