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Predictive factors of psoriatic arthritis in a diverse population with psoriasis

Objective: We aimed to analyze the clinical characteristics of patients with psoriasis and determine the predictive factors of psoriatic arthritis (PsA). Methods: This retrospective cohort study was performed among patients with psoriasis. Demographic and clinical data were collected. Psoriasis trea...

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Main Authors: Loo, Wai Yang, Tee, Ying Chew, Han, Winn Hui, Faheem, Nik Aimee Azizah, Yong, Shin Shen, Kwan, Zhenli, Pok, Lydia Say Lee, Yahya, Fariz
Format: Article
Published: SAGE Publications 2024
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RL Dermatology
Online Access:http://eprints.um.edu.my/44199/
https://doi.org/10.1177/03000605231221014
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spelling my.um.eprints.441992024-06-20T01:58:54Z http://eprints.um.edu.my/44199/ Predictive factors of psoriatic arthritis in a diverse population with psoriasis Loo, Wai Yang Tee, Ying Chew Han, Winn Hui Faheem, Nik Aimee Azizah Yong, Shin Shen Kwan, Zhenli Pok, Lydia Say Lee Yahya, Fariz RL Dermatology Objective: We aimed to analyze the clinical characteristics of patients with psoriasis and determine the predictive factors of psoriatic arthritis (PsA). Methods: This retrospective cohort study was performed among patients with psoriasis. Demographic and clinical data were collected. Psoriasis treatment was categorized as topical agents, phototherapy, oral therapy, and biologics. Predictive factors of PsA development were determined using logistic regression analyses.ResultsWe included 330 patients with psoriasis, and 83 (25%) patients developed PsA. Thirty-eight (45.8%) patients who developed PsA were Malay, 24 (28.9%) were Chinese, and 21 (25.3%) were Indian. The mean age of patients with PsA was 54.2 (+/- 15.8) years, and the duration from diagnosis of psoriasis to diagnosis of PsA was 36 (3.5-114) months. Predictive factors for developing PsA were female sex (odds ratio OR] = 3.33, 95% confidence interval CI] 1.78-6.22), presence of nail involvement (OR = 5.36, 95% CI 2.50-11.51), severe psoriasis (OR = 27.41, 95% CI 7.58-99.11), and oral systemic therapy prior to PsA diagnosis (OR = 4.09, 95% CI 2.04-8.22). Conclusion: Patients with psoriasis who are female, have nail involvement, have severe skin psoriasis, and require oral systemic therapy for psoriasis may have an increased risk of developing PsA. SAGE Publications 2024-01 Article PeerReviewed Loo, Wai Yang and Tee, Ying Chew and Han, Winn Hui and Faheem, Nik Aimee Azizah and Yong, Shin Shen and Kwan, Zhenli and Pok, Lydia Say Lee and Yahya, Fariz (2024) Predictive factors of psoriatic arthritis in a diverse population with psoriasis. Journal of International Medical Research, 52 (1). ISSN 0300-0605, DOI https://doi.org/10.1177/03000605231221014 <https://doi.org/10.1177/03000605231221014>. https://doi.org/10.1177/03000605231221014 10.1177/03000605231221014
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic RL Dermatology
spellingShingle RL Dermatology
Loo, Wai Yang
Tee, Ying Chew
Han, Winn Hui
Faheem, Nik Aimee Azizah
Yong, Shin Shen
Kwan, Zhenli
Pok, Lydia Say Lee
Yahya, Fariz
Predictive factors of psoriatic arthritis in a diverse population with psoriasis
description Objective: We aimed to analyze the clinical characteristics of patients with psoriasis and determine the predictive factors of psoriatic arthritis (PsA). Methods: This retrospective cohort study was performed among patients with psoriasis. Demographic and clinical data were collected. Psoriasis treatment was categorized as topical agents, phototherapy, oral therapy, and biologics. Predictive factors of PsA development were determined using logistic regression analyses.ResultsWe included 330 patients with psoriasis, and 83 (25%) patients developed PsA. Thirty-eight (45.8%) patients who developed PsA were Malay, 24 (28.9%) were Chinese, and 21 (25.3%) were Indian. The mean age of patients with PsA was 54.2 (+/- 15.8) years, and the duration from diagnosis of psoriasis to diagnosis of PsA was 36 (3.5-114) months. Predictive factors for developing PsA were female sex (odds ratio OR] = 3.33, 95% confidence interval CI] 1.78-6.22), presence of nail involvement (OR = 5.36, 95% CI 2.50-11.51), severe psoriasis (OR = 27.41, 95% CI 7.58-99.11), and oral systemic therapy prior to PsA diagnosis (OR = 4.09, 95% CI 2.04-8.22). Conclusion: Patients with psoriasis who are female, have nail involvement, have severe skin psoriasis, and require oral systemic therapy for psoriasis may have an increased risk of developing PsA.
format Article
author Loo, Wai Yang
Tee, Ying Chew
Han, Winn Hui
Faheem, Nik Aimee Azizah
Yong, Shin Shen
Kwan, Zhenli
Pok, Lydia Say Lee
Yahya, Fariz
author_facet Loo, Wai Yang
Tee, Ying Chew
Han, Winn Hui
Faheem, Nik Aimee Azizah
Yong, Shin Shen
Kwan, Zhenli
Pok, Lydia Say Lee
Yahya, Fariz
author_sort Loo, Wai Yang
title Predictive factors of psoriatic arthritis in a diverse population with psoriasis
title_short Predictive factors of psoriatic arthritis in a diverse population with psoriasis
title_full Predictive factors of psoriatic arthritis in a diverse population with psoriasis
title_fullStr Predictive factors of psoriatic arthritis in a diverse population with psoriasis
title_full_unstemmed Predictive factors of psoriatic arthritis in a diverse population with psoriasis
title_sort predictive factors of psoriatic arthritis in a diverse population with psoriasis
publisher SAGE Publications
publishDate 2024
url http://eprints.um.edu.my/44199/
https://doi.org/10.1177/03000605231221014
_version_ 1805881133958692864
score 13.211869

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