Cover Image

Ethnopharmacology, biological evaluation, and chemical composition of Ziziphus spina - Christi (L.) Desf.: A Review

Medicinal plants are the primary raw materials used in the production of medicinal products all over the world. As a result, more study on plants with therapeutic potential is required. The tropical tree Ziziphus spina belongs to the Rhamnaceae family. Biological reports and traditional applications...

Full description

Saved in:
Bibliographic Details
Main Authors: Abdulrahman, Mahmoud Dogara, Zakariya, Ali Muhammad, Hama, Harmand A., Hamad, Saber W., Al-Rawi, Sawsan S., Bradosty, Sarwan W., Ibrahim, Ahmad H.
Format: Article
Published: Hindawi Limited 2022
Subjects:
QH301 Biology
Online Access:http://eprints.um.edu.my/43587/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.um.eprints.43587
record_format eprints
spelling my.um.eprints.435872023-10-30T03:30:09Z http://eprints.um.edu.my/43587/ Ethnopharmacology, biological evaluation, and chemical composition of Ziziphus spina - Christi (L.) Desf.: A Review Abdulrahman, Mahmoud Dogara Zakariya, Ali Muhammad Hama, Harmand A. Hamad, Saber W. Al-Rawi, Sawsan S. Bradosty, Sarwan W. Ibrahim, Ahmad H. QH301 Biology Medicinal plants are the primary raw materials used in the production of medicinal products all over the world. As a result, more study on plants with therapeutic potential is required. The tropical tree Ziziphus spina belongs to the Rhamnaceae family. Biological reports and traditional applications including management of diabetes and treatment of malaria, digestive issues, typhoid, liver complaints, weakness, skin infections, urinary disorders, obesity, diarrhoea, and sleeplessness have all been treated with different parts of Z. spina all over the globe. The plant is identified as a rich source of diverse chemical compounds. This study is a comprehensive yet detailed review of Z. spina based on major findings from around the world regarding ethnopharmacology, biological evaluation, and chemical composition. Scopus, Web of Science, BioMed Central, ScienceDirect, PubMed, Springer Link, and Google Scholar were searched to find published articles. From the 186 research articles reviewed, we revealed the leaf extract to be significant against free radicals, microbes, parasites, inflammation-related cases, obesity, and cancer. Chemically, polyphenols/flavonoids were the most reported compounds with a composition of 66 compounds out of the total 193 compounds reported from different parts of the plant. However, the safety and efficacy of Z. spina have not been wholly assessed in humans, and further well-designed clinical trials are needed to corroborate preclinical findings. The mechanism of action of the leaf extract should be examined. The standard dose and safety of the leaf should be established. © 2022 Mahmoud Dogara Abdulrahman et al. Hindawi Limited 2022 Article PeerReviewed Abdulrahman, Mahmoud Dogara and Zakariya, Ali Muhammad and Hama, Harmand A. and Hamad, Saber W. and Al-Rawi, Sawsan S. and Bradosty, Sarwan W. and Ibrahim, Ahmad H. (2022) Ethnopharmacology, biological evaluation, and chemical composition of Ziziphus spina - Christi (L.) Desf.: A Review. Advances in Pharmacological and Pharmaceutical Sciences, 2022. ISSN 26334682, DOI https://doi.org/10.1155/2022/4495688 <https://doi.org/10.1155/2022/4495688>. 10.1155/2022/4495688
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QH301 Biology
spellingShingle QH301 Biology
Abdulrahman, Mahmoud Dogara
Zakariya, Ali Muhammad
Hama, Harmand A.
Hamad, Saber W.
Al-Rawi, Sawsan S.
Bradosty, Sarwan W.
Ibrahim, Ahmad H.
Ethnopharmacology, biological evaluation, and chemical composition of Ziziphus spina - Christi (L.) Desf.: A Review
description Medicinal plants are the primary raw materials used in the production of medicinal products all over the world. As a result, more study on plants with therapeutic potential is required. The tropical tree Ziziphus spina belongs to the Rhamnaceae family. Biological reports and traditional applications including management of diabetes and treatment of malaria, digestive issues, typhoid, liver complaints, weakness, skin infections, urinary disorders, obesity, diarrhoea, and sleeplessness have all been treated with different parts of Z. spina all over the globe. The plant is identified as a rich source of diverse chemical compounds. This study is a comprehensive yet detailed review of Z. spina based on major findings from around the world regarding ethnopharmacology, biological evaluation, and chemical composition. Scopus, Web of Science, BioMed Central, ScienceDirect, PubMed, Springer Link, and Google Scholar were searched to find published articles. From the 186 research articles reviewed, we revealed the leaf extract to be significant against free radicals, microbes, parasites, inflammation-related cases, obesity, and cancer. Chemically, polyphenols/flavonoids were the most reported compounds with a composition of 66 compounds out of the total 193 compounds reported from different parts of the plant. However, the safety and efficacy of Z. spina have not been wholly assessed in humans, and further well-designed clinical trials are needed to corroborate preclinical findings. The mechanism of action of the leaf extract should be examined. The standard dose and safety of the leaf should be established. © 2022 Mahmoud Dogara Abdulrahman et al.
format Article
author Abdulrahman, Mahmoud Dogara
Zakariya, Ali Muhammad
Hama, Harmand A.
Hamad, Saber W.
Al-Rawi, Sawsan S.
Bradosty, Sarwan W.
Ibrahim, Ahmad H.
author_facet Abdulrahman, Mahmoud Dogara
Zakariya, Ali Muhammad
Hama, Harmand A.
Hamad, Saber W.
Al-Rawi, Sawsan S.
Bradosty, Sarwan W.
Ibrahim, Ahmad H.
author_sort Abdulrahman, Mahmoud Dogara
title Ethnopharmacology, biological evaluation, and chemical composition of Ziziphus spina - Christi (L.) Desf.: A Review
title_short Ethnopharmacology, biological evaluation, and chemical composition of Ziziphus spina - Christi (L.) Desf.: A Review
title_full Ethnopharmacology, biological evaluation, and chemical composition of Ziziphus spina - Christi (L.) Desf.: A Review
title_fullStr Ethnopharmacology, biological evaluation, and chemical composition of Ziziphus spina - Christi (L.) Desf.: A Review
title_full_unstemmed Ethnopharmacology, biological evaluation, and chemical composition of Ziziphus spina - Christi (L.) Desf.: A Review
title_sort ethnopharmacology, biological evaluation, and chemical composition of ziziphus spina - christi (l.) desf.: a review
publisher Hindawi Limited
publishDate 2022
url http://eprints.um.edu.my/43587/
_version_ 1781704713826205696
score 13.211869

Similar Items